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Symeon schematic

Control of lipid partitioning by the conserved yeast lipin Pah1. Loss of Pah1 results in de-repressed nuclear/ER membrane proliferation (arrows, left panel). Conversely, constitutive activation of Pah1 results in lipid droplet accumulation (arrows, right panel).
Symeon schematic
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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

New publications


Lehner lab (Cell Rep. 2016)

ATF7IP is a key effector of the HUSH complex.


Robinson lab (eLife 2016)

Tetherin as an exosomal tether.


Marciniak lab (FASEB J. 2016)

ER transport after fragmentation.


Luzio lab (Curr. Biol. 2016)

Re-evaluating the lysosome regeneration cycle.


Lehner lab (Traffic 2016)

Trafficking control of tetherin.


Rubinsztein lab (Nature Comm. 2016)

Autophagy-lysosome dysfunction in Parkinson's disease.