Cambridge Institute for Medical Research

Dr Andres Floto

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Key Publications

Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA. (2011). Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection. J Clin Invest. 121, 3554-63.

Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA & Rubinsztein DC. (2008). Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol. 4, 295-305.

Floto, R.A., Sarkar, S, Perlstein, E.O., Kampmann, B., Schreiber, S.L. & Rubinsztein, D.C. (2007). Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington’s disease models and enhance killing of mycobacteria by macrophages. Autophagy 3, 620-622.

Clatworthy, M.R., Willcocks, L., Urban, B.,Langhorne, J., Williams, T., Watkins, N.A., Rankin, A., Floto, R.A. & Smith, K.G.C. (2007). SLE-associated defects in the inhibitory receptor FcgRIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A. 104, 7169-7174.

Floto, R.A., MacAry, P.A., Boname, J.M., Mien, T.S., Houben, E.N.G., Pieters, J., Day, C., Oehlmann, W., Singh, M., Smith, K.G.C. & Lehner, P.J. (2006). Dendritic cell stimulation by mycobacterial HSP70 is mediated through the HIV co-receptor CCR5. Science 314, 454-458.

Floto, R.A., Clatworthy, M.R., Heilbronn, K.R., Rosner, D.R., MacAry, P.A., Rankin, A., Lehner, P.J., Ouwehand, W.H., Allen, J.M., Watkins, N.A. & Smith, K.G.C (2005). An SLE-associated polymorphism of the inhibitory receptor FcgRIIb excludes it from lipid rafts and leads to loss of function. Nature Medicine, 11, 1056-1058.