Cambridge Institute for Medical Research

Professor Bertie Gottgens

Home | Research Profile | Key Publications

Key Publications

Göttgens B., Barton L.M., Gilbert J.G., Bench A.J., Sanchez M.J., Bahn S., Mistry S., Grafham D., McMurray A., Vaudin M., Amaya E., Bentley D.R. and Green A.R. (2000).  "Analysis of vertebrate SCL loci identifies conserved enhancers". Nature Biotech, 18: 181-6.

Göttgens B., Gilbert J.G.R., Barton L.M., Grafham D., Bentley D. and Green A.R. (2001).  "Long-Range Comparison of Human and Mouse SCL Loci: Localized Regions of Sensitivity to Restriction Endonucleases Correspond Precisely with Peaks of Conserved Noncoding Sequence”. Genome Research 11: 87-97.

Göttgens B., Barton L.M., Chapman M.A., Sinclair A.M., Knudsen B., Grafham D., Gilbert J.G.R., Rogers J., Bentley D. and Green A.R. (2002). “Transcriptional Regulation of the Stem Cell Leukaemia Gene - Comparative Analysis of Five Vertebrate SCL Loci”. Genome Research 12 (5): 749-759.

Göttgens B., Nastos A., Kinston S., Stanley M., Piltz S., Delabesse E., Sanchez M.J., Patient R. and Green A.R. (2002). “Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors”. EMBO J 21 (12): 3039-3050.

Chapman M.A., Charchar F.J., Kinston S., Bird C.P., Grafham D., Rogers J., Grutzner F., Marshall Graves J.A., Green A.R., Göttgens B. (2003). “Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting” Genomics 81(3): 249-259

Chapman M.A., Donaldson I.J., Gilbert J.G.R., Grafham D., Rogers J., Green A.R., Göttgens B. (2004). “Analysis of Multiple Genomic Sequence Alignments – a Web Resource, Online Tools, and Lessons Learned from Analysis of Mammalian SCL Loci” Genome Research 14(2): 313-318

Göttgens B., Broccardo C., Sanchez M.J., Deveaux S., Murphy G., Göthert J.R., Kotsopoulou E., Kinston S., Delaney L., Piltz S., Barton L.M., Knezevic K., Erber W.N., Begley C.G., Frampton J., Green A.R. (2004). “The scl +18/19 Stem Cell Enhancer is not Required for Haematopoiesis: Identification of a 5’ Bifunctional Haematopoietic/Endothelial Enhancer Bound by Fli-1 and Elf-1”. Mol Cell Biol 24(5): 1870-1883

Donaldson I.J., Chapman M., Kinston S., Landry J.R., Knezevic K., Piltz S., Buckley N., Green A.R., Göttgens B. (2005) “Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development” Hum Mol Genet 14(5): 595-601

Donaldson I.J., Chapman M., Göttgens B. (2005) “TFBScluster: a resource for the characterisation of transcriptional regulatory networks” Bioinformatics 21(13): 3058-3059

Silberstein L., Sanchez M.J., Socolovsky M., Liu Y., Hoffman G., Kinston K., Piltz S., Bowen M., Gambardella L., Green A.R., Göttgens B. (2005) “Transgenic Analysis of the SCL +19 Stem Cell Enhancer in Adult and Embryonic Haematopoietic and Endothelial Cells” Stem Cells 2005 23: 98-102

Landry J.-R., Kinston S., Knezevic K., Donaldson I.J., Green A.R., Göttgens B. (2005) “Fli1, Elf1 and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells” Blood 2005 106(8): 2680-2687

Donaldson I.J., Göttgens B. (2006) “Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence” Genome Biology 7(6): R52

Pimanda J.E, Chan W.Y.I., Donaldson I.J., Bowen M., Green A.R., Göttgens B. (2006) “Endoglin expression in the endothelium is regulated by Fli-1, Erg and Elf-1 acting on the promoter and a –8kb enhancer” Blood 107(12): 4737-4745

Castro D.S., Skowronska-Krawczyk D., Armant O., Donaldson I.J., Parras C., Hunt C., Critchley J., Nguyen L., Gossler A., Göttgens B., Matter J.-M., Guillemot F. (2006) “Proneural bHLH and Brn proteins co-regulate a neurogenic programme through cooperative binding to a conserved DNA motif” Dev Cell 11: 831-844

Chan W.Y.I., Follows G.A., Lacaud G., Pimanda J.E., Landry J.R., Kinston S., Knezevic K., Piltz S., Donaldson I.J., Gambardella L., Sablitzky F., Green A.R., Kouskoff V., Göttgens B. (2007) “The paralogous haemopoietic regulators Lyl1 and SCL are co-regulated by Ets and GATA factors yet Lyl1 cannot rescue the early SCL-/- phenotype” Blood 109(5): 1908-1916

Pimanda J.E., Donaldson I.J., de Bruijn M.F.T.R., Kinston S., Knezevic K., Huckle L., Piltz S., Landry J.R. Green A.R., Tannahill D., Göttgens B. (2007) “The SCL transcriptional network and the BMP signaling pathway interact to regulate RUNX1 activity” Proc. Natl. Acad. Sci. USA 104(3): 840-845

Pimanda J.E., Ottersbach K., Knezevic K., Kinston S., Chan W.Y.I., Wilson N.K., Landry J.R., Wood A.D., Kolb-Kokocinsky A., Green A.R., Tannahill D., Lacaud G., Kouskoff V., Göttgens B. (2007) “Gata2, Fli1 and Scl form a recursively wired gene regulatory circuit in early developing blood cells” Proc. Natl. Acad. Sci. USA 104(45): 17692-17697

Landry J.R., Kinston S., Knezevic K., de Bruijn M.F.T.R., Wilson N., Nottingham W.T., Peitz M., Edenhofer F., Pimanda J.E., Ottersbach K., Göttgens B. (2008) “Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver” Blood 111(6): 3005-3014

Smith A.M., Sanchez M.J., Follows G.A., Kinston S., Donaldson I.J., Green A.R., Göttgens B. (2008) “A novel mode of enhancer evolution: The Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity” Genome Research 18: 1422-1432

Pimanda J.E., Chan W.Y.I., Wilson N.K., Smith A.M., Kinston S., Knezevic K., Janes M.E., Landry J.R., Kolb-Kokocinsky A., Frampton J., Tannahill D., Ottersbach K., Follows G.A., Lacaud G., Kouskoff V., Göttgens B. (2008) “Endoglin Expression in Blood and Endothelium is Differentially Regulated by Modular Assembly of the Ets/Gata Hemangioblast Code” Blood 112 (12): 4512-4522

Miranda-Saavedra D., De S., Trotter M.W., Teichmann S.A., Göttgens B. (2009) “BloodExpress: a database of gene expression in mouse haematopoiesis” Nucleic Acids Res. 37: D873-D879

Landry J.R., Bonadies N., Kinston S., Knezevic K., Wilson N., Oram S.H., Janes M., Piltz S., Hammett M., Carter J., Hamilton T., Donaldson I.J., Lacaud G., Frampton J., Follows G., Kouskoff V., Göttgens B. (2009) “Expression of the leukaemia oncogene Lmo2 is controlled by an array of tissue specific elements dispersed over 100 kb and bound by Scl/Lmo2, Ets and Gata factors” Blood 113(23):5783-92

Wilson N.K., Miranda-Saavedra D., Kinston S.J., Bonadies N., Foster S.D., Calero-Nieto F., Dawson M.A., Donaldson I.J., Dumon S., Frampton J., Janky R., Sun X.-H., Teichmann S.A., Bannister A.J., Göttgens B. (2009) “The transcriptional program controlled by the stem cell leukaemia gene Scl/Tal1 during early embryonic hematopoietic development” Blood 113(22):5456-65. 

Wood A.D., Chen E., Donaldson I., Hattangadi S., Burke K., Dawson M.A., Miranda-Saavedra D., Lodish H.F., Green A.R., Göttgens B. (2009) “Id1 Promotes Expansion and Survival of Primary Erythroid Cells and is a Target of JAK2V617F-STAT5 Signaling” Blood 114(9): 1820-1830

Kantorovitz M.R., Kazemian M., Kinston S., Miranda-Saavedra D., Zhu Q., Robinson G.E., Göttgens B.*, Halfon M.S.*, Sinha S.* (2009) “Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse” Developmental Cell 17:  568–579
* joint senior authors

Dawson M.A., Bannister A.J., Göttgens B., Foster S.D., Bartke T., Green A.R., Kouzarides T. (2009) “JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin” Nature461(7265): 819-822