Cambridge Institute for Medical Research

Professor Gillian Griffiths

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Key Publications

Stinchcombe, JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM.
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells both the innate and adaptive immune systems.
BMC Biol. 2011, 9, 45.

Tsun A, Quereshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.
Centrosome docking at the immunological synapse is controlled by Lck signaling.
J Cell Biol. 2011, 192, 663-74.

Griffiths GM, Tsun A, Stinchcombe JC.
The immunological synapse: a focal point for endocytosis and exocytosis.
J Cell Biol. 2010, 189, 399-406.

Cetica V, Santoro A, Gilmour KC, Sieni E, Beutel K, Pende D, Marcenaro S, Koch F, Grieve S, Wheeler R, Zhao F, zur Stadt U, Griffiths GM, Aricò M.
STXBP2 mutations in children with familial hemophagocytic lymphohistiocytosis type 5.
J Med Genet. 2010, 47, 595-600.

Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM.
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.
Immunity. 2009, 31, 621-31.

Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM.
Centrosome polarisation delivers secretory granules to the immunological synapse for secretion.
Nature. 2006, 443, 462-5. Erratum in: Nature. 2006, 444, 236.