Cambridge Institute for Medical Research

Dr Brian Huntly

Dr Brian Huntly

Home | Research Profile | Key Publications

Key Publications

  • Chan WI, Dawson  MA, Hannah R, Paul D, Pridans C, Joshi A, Gottgens B, Van Deursen J, Huntly BJP. The transcriptional coactivator Cbp controls hematopoietic stem cell quiescence and multipotential differentiation. Mol Cell Biol. 2011 Dec;31(24):5046-60. Epub 2011 Oct 17
  • van der Weyden L, Giotopolous G, Rust AG, Matheson L, van Delft F, Kong J, Corcoran A, Huntly BJ*, Adams DJ*. Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice. Blood. 2011; 118(4):1041-51. Epub 2011 May 31.
    *joint senior authors
  • Kvinlaug BT, Chan WI, Bullinger L, Sears C, Paul D, Okabe R, Lee BH, Benner A, De Silva I, Valk P, Delwel R, Armstrong SA, Döhner H, Gilliland DG, Huntly BJP. Common and overlapping pathways contribute to the evolution of acute myeloid leukaemias. Cancer Res. 2011; 71(12):4117-29. Epub 2011 Apr 19.
  • Li P, Burke S, Chen X, Ortiz M, Lee S-C, Lu D, Campos L, Dougan G, Huntly BJP, Gottgens B,  Jenkins N, Copeland NC, Colucci F, Liu P. Reprogramming of T Cells to Natural Killer-like Cells upon Bcl11b Deletion. Science. 2010 Jul 2; 329(5987):85-9.
  • Zhao R, Follows GA, Beer PA, Huntly BJP, Green AR, Alexander DR. Inhibition of the Bcl-xL deamidation pathway in  myeloproliferative disorders N Engl J Med. 2008; 359(26): 2778-89.
  • Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJP, Lee BH, Rücker  FG, Schlenk RF, Bullinger L, Döhner H, Gilliland DG, and Fröhling S. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest. 2007 Apr 2;117(4):1037-1048.
  • Tothova Z, Kollipara R, Huntly BJ, Lee BH, Catrillion D, Passegue E, Cullen D, McDowell E, Lazo-Kallanian S, Williams I, DePinho R, Gilliland DG. FoxO are critIcal mediators of stem cell resistance to physiologic oxidative stress Cell. 2007 Jan 26;128(2):325-39.
  • Lee B H, Tothova Z, Levine RL, Anderson K, Cullen DE, McDowell EP, Adelsperger J,. Huntly BJP, Beran M, Jacobsen SE, Gilliland DG. FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Cancer Cell. 2007;12: 367-80.
  • Bansal D, Scholl C, Frohling S, McDowell E, Lee BH, Dohner K, Ernst P, Davidson A, Daley GQ, Zon LI, Gilliland DG and Huntly BJP. Cdx4 upregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 2006; 103:16924-9.
  • Levine, RL. Wadleigh, M. Cools, J. Ebert, BL. Wernig, G. Huntly, BJP. Boggon, TJ. Wlodarska, I. Clark, JJ. Moore, S. Adelsberger, J. Koo, S. Lee, J. Gabriel, S. Marynen, P. Vandenberghe, P. Mesa, RA. Tefferi, A. Griffin, JD. Eck, MJ. Sellers, WJ. Meyerson, M. Golub, TR. Lee, SJ. and Gilliland DG. Activating Mutation in the Tyrosine Kinase JAK2 in Polycythemia Vera, Essential Thrombocythemia and Myeloid Metaplasia with Myelofibrosis. Cancer Cell. 2005; 7: 387-397.
  • Weisberg, E. Manley, P W. Breitenstein, W.  Brüggen, Cowan-Jacob, S.W., Ray, A.  Huntly, B.J.P., J. Callahan, L. Fabbro, D. Fendrich, G. Hall-Mey ers, E. Kung, A. Mestan, J. Neuberg, D. Gilliland, D.G. and Griffin, J.D. AMN107:  Characterization of a novel inhibitor of both wild-type and mutant Bcr-Abl in vitro and in murine models of leukaemia. Cancer Cell. 2005; 7: 129-141.
  • Huntly BJP, Shigematzu H, Deguchi K, Lee BH, Mizuno S, Duclos N, Rowan R, Amaral S, Curley D, Williams IR, Akashi K and Gilliland, DG. MOZ-TIF2, but not BCR-ABL, confers properties of leukaemic stem cells to committed murine haematopoietic progenitors. Cancer Cell. 2004; 6: 586-595

Selected Reviews

  • Dawson  MA, Kouzarides T, Huntly BJP. Targeting epigenetic readers in hematological malignancies. 2012 (Invited review for N Engl J Med)
  • Chan, WI and Huntly BJP. Leukaemia stem cells in AML. Semin Oncol  2008; 34: 326-335
  • Huntly BJP and Gilliland DG. Leukemia Stem Cells and the Evolution of Cancer Stem Cells. Nature Reviews Cancer. 2005; 5: 311-321