Cambridge Institute for Medical Research

Professor Paul Lehner

Professor Paul Lehner

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Key Publications

  • Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ. HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation.Proc Natl Acad Sci (2011) 108:2034-9
  • Cano F, Miranda-Saavedra D, Lehner PJ.   RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation.   Biochem Soc Trans. 2010 Dec 1;38(6):1621-6.
  • Duncan, LM, Nathan JA, Lehner PJ. Stabilisation of an E3 ligase-E2-Ubiquitin complex increases cell surface MHC Class I expression. J Immunol. 2010
  • Boname JM, Thomas M, Stagg HR, Xu P, Peng J, Lehner PJ.  Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains. Traffic (2010) 210 - 220
  • Stagg, HR, Thomas M, Van den Boomen D, Wiertz EH, Drabkin HA, Gemmill RM and Lehner PJ. The TRC8 E3 Ligase ubiquitinates MHC class I molecules before dislocation from the ER Journal of Cell Biology (2009) 186(5):685-92
  • Markson G, Kiel C, Hyde AR, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson C.  Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.  Genome Research. (2009) 19(10):1905-11
  • SILAC labeling and differential plasma membrane proteome quantitation identifies new substrates for the MARCH9 transmembrane E3 ligase. Hör S, Ziv T, Admon A, Lehner PJ. Molecular and Cellular Proteomics (2009) 8(8):1959-71.
  • Viral avoidance and exploitation of the ubiquitin system. Randow F, Lehner PJ.  Nature
                Cell Biology (2009)11(5):527-34.
  • Thomas, M, Boname, JM, Field, S, Nejentsev, S, Salio, M, Cerundolo, V, Wills M, Lehner PJ. (2008). Downregulation of NKG2D and NKp80 ligands by Kaposi’s sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity Proc Natl Acad Sci 105:1656-61
  • Nathan JA, Sengupta SS, Wood SA, Admon A,  Markson GB, Sanderson CM, Lehner PJ (2008) The Ubiquitin E3 Ligase MARCH7 is Differentially Regulated by the Deubiquitylating Enzymes USP7 and USP9X. Traffic 9:1-16
  • Floto, RA, MacAry, PA, Boname, JM, Mien, TS, Kampmann, B, Hair, JR, Huey, OS, Houben, EN, Pieters, J, Day, C, Oehlmann, W, Singh, Smith, KGC and Lehner, PJ (2006) Dendritic Cell Stimulation by Mycobacterial HSP70 is Mediated Through CCR5 Science 314:454-8
  • Duncan, LM, Piper, S, Dodd, RB, Saville, MK, Sanderson, CM, Luzio JP and Lehner PJ (2006) Lysine-63 Linked Ubiquitination Is Required For Endolysosomal Degradation of Class I Molecules EMBO Journal 25:1635-1645
  • Lehner PJ, Hoer S, Dodd R and Duncan LM (2005) Downregulation of Cell Surface Receptors by the K3 family of Viral and Cellular Ubiquitin E3 Ligases. Immunological Reviews 207:12-125
  • Hewitt, EW, Duncan, L, Mufti, D, Baker, J, Stevenson, P, and Lehner, PJ. (2002) Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO Journal 21:2418 – 29.