Cambridge Institute for Medical Research

Professor David Owen

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Key Publications

• Molecular Architecture and Functional Model of the Endocytic AP2 Complex.
  Collins BM, McCoy AJ, Kent HM, Evans PR, and Owen DJ. 
  Cell 2002, Vol 109, p523-535.
• Adaptors for clathrin coats: structure and function.
  Owen, DJ., Collins, BM. & Evans, PR.
  Annu Rev Cell Dev Biol 2004, Vol 20, p153-191.
• Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly.
  Collins, BM., Skinner, CF., Watson, PJ., Seaman, MN. & Owen, DJ.
  Nat Struct Mol Biol 2005, Vol 12, p594-602.
• Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2
  Honing, S., Ricotta, D., Krauss, M., Spate, K., Spolaore, B., Motley, A., Robinson, M., Robinson, C., Haucke, V. & Owen, DJ.
  Mol Cell 2005, Vol 18, p519-531.
• Life of a clathrin coat: insights from clathrin and AP structures.
  Edeling MA, Smith C*, Owen DJ*.
  Nat Rev Mol Cell Biol. 2006, Vol 7, p32-44.
• Molecular switches involving the AP2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly
  Edeling MA, Mishra SK, Keyel PA, Steinhauser AL, Collins BM, Roth R, Heuser JE, Owen DJ*, Traub LM*.
  Dev Cell 2006, Vol 10,  p329-342.
• A SNARE-clathrin adaptor interaction reveals a new mode of cargo recognition for clathrin-coated vesicles
  Miller SE, Collins BM, McCoy AJ, Robinson MS* and Owen DJ*
  Nature 2007, Vol 450, p570-574.
• Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.
  Pryor PR, Jackson L, Gray SR, Edeling MA, Thompson A, Sanderson CM, Evans PR, Owen DJ*, Luzio JP*.
  Cell. 2008, Vol 134, p817-827.

(* indicates joint corresponding/senior author)