Cambridge Institute for Medical Research

Professor Randy Read

Professor Randy Read

Home | Research Profile | Key Publications

Key publications: structural studies

  • Dodd, R.B., Allen, M.D., Brown, S.E., Sanderson, C.M., Duncan, L.M., Lehner, P.J., Bycroft, M. & Read, R.J. (2004). Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a novel E2-binding C4HC3-type RING domain. J. Biol. Chem. 279: 53840-53847.
  • Zhou, A.W., Wei, Z., Stanley, P.L.D., Read, R.J., Stein, P.E. and Carrell, R.W. (2008). The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J. Mol. Biol. 380: 244-251.
  • Zhou, A., Carrell, R.W., Murphy, M.P., Wei, Z., Yan, Y., Stanley, P.L.D., Stein, P.E., Broughton Pipkin, F. and Read, R.J. (2010). A redox switch in angiotensinogen modulates angiotensin release. Nature 468: 108-111.
  • Deane, J.E., Graham, S.C., Kim, N.N., Stein, P.E., McNair, R., Cachón-González, M.B., Cox, T.M. and Read, R.J. (2011). Insights into Krabbe disease from structures of galactocerebrosidase. Proc. Natl. Acad. Sci. USA. 108: 15169-15173.

Key publications: methods

  • McCoy, A.J., Grosse-Kunstleve, R.W., Adams, P.D., Winn, M.D., Storoni, L.C. and Read, R.J. (2007). Phaser crystallographic software. J. Appl. Cryst. 40: 658-674.
  • Qian, B., Raman, S., Das, R., Bradley, P., McCoy, A.J., Read, R.J. and Baker, D. (2007). High-resolution structure prediction and the crystallographic phase problem. Nature 450, 259-264.
  • Adams, P.D., Afonine, P.V., Bunkóczi, G., Chen, V.B., Davis, I.W., Echols, N., Headd, J.J., Hung, L.-W., Kapral, G.J., Grosse-Kunstleve, R.W., McCoy, A.J., Moriarty, N.W., Oeffner, R., Read, R.J., Richardson, D.C., Richardson, J.S., Terwilliger, T.C. and Zwart, P.H. (2010). PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Cryst. D66: 213-221.
  • DiMaio, F., Terwilliger, T.C., Read, R.J., Wlodawer, A., Oberdorfer, G., Wagner, U., Valkov, E., Alon, A., Fass, D., Axelrod, H.L., Das, D., Vorobiev, S.M., Iwaï, H., Pokkuluri, P.R. and Baker, D. (2011). Improving molecular replacement by density- and energy-guided protein structure optimization. Nature 473: 540-543.