Cambridge Institute for Medical Research

Professor David Rubinsztein

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Key Publications

• K Moreau, B Ravikumar, M Renna, C Puri, and DC Rubinsztein (2011) Autophagosome precursor maturation requires homotypic fusion. Cell 146:303-317
  


• S Sarkar, VI Korolchuk, M Renna, S Imarisio, A Fleming, A Williams, M Garcia-Arencibia, C Rose, S Luo, BR Underwood, G Kroemer, CJ O’Kane, and DC Rubinsztein (2011) Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 43:19-32


• VI Korolchuk, S Saiki, M Lichtenberg, FH Siddiqi, EA Roberts, S Imarisio, L Jahreiss, S Sarkar, M Futter, FM Menzies, CJ O’Kane, V Deretic and DC Rubinsztein (2011) Lysosomal positioning coordinates cellular nutrient responses. Nature Cell Biology 13:453-460


• B Ravikumar, K Moreau, L Jahreiss, C Puri and DC Rubinsztein (2010) Plasma membrane contributes to the formation of pre-autophagosomal structures. Nature Cell Biology 12:747-757


• AR Winslow, C-W Chen, S Corrochano, A Acevedo-Arozena, DE Gordon, A A Peden, M Lichtenberg, FM Menzies, B Ravikumar, S Imarisio, S Brown, CJ O’Kane, and DC Rubinsztein (2010)  Alpha-synuclein impairs macroautophagy: implications for Parkinson’s disease. J Cell Biol 190:1023-1037.


• TJ van Ham, M Holmberg, A van der Goot, E Teuling, M Garcia-Arencibia, H Kim, D Du, KL Thijssen, M Wiersma, R Burggraaff, P van Bergeijk, J van Rheenen, G Jerre van Veluw, RMW Hofstra, DC Rubinsztein and EAA Nollen (2010) Identification of MOAG-4/SERF as a  regulator of age-related proteotoxicity. Cell 142:601-612


• VI Korolchuk, A Mansilla, FM Menzies and DC Rubinsztein (2009). Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Molecular Cell 33:517-527


• A Williams, S Sarkar, P Cuddon, EK Ttofi, S Saiki, FH. Siddiqi, L Jahreiss, A Fleming, D Pask, P Goldsmith, CJ O’Kane, RA Floto and DC Rubinsztein (2008) Novel targets for Huntington’s disease in an mTOR-independent autophagy pathway.  Nature Chemical Biology 4: 295-305


• S Sarkar, EO Perlstein, S Imarisio, S Pineau, A Cordenier, RL Maglathlin, JA Webster, TA Lewis, CJ O’Kane, SL Schreiber, and DC Rubinsztein (2007) Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Nature Chemical Biology 3, 331-338


• S Sarkar, RA Floto, Z Berger, S Imarisio, A Cordenier, M Pasco, LJ Cook and DC Rubinsztein (2005). Lithium induces autophagy by inhibiting inositol monophosphatase. Journal of Cell Biology 170: 1101-1111


• B Ravikumar, A Acevedo-Arozena, S Imarisio, Z Berger, C Vacher, CJ O’Kane, SDM Brown and DC Rubinsztein (2005). Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nature Genetics 37:771-776


• S Luo, C Vacher, JE Davies and DC Rubinsztein (2005) Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity. J Cell Biology 169:647-656.


• JE Davies, L Wang, L Garcia-Oroz, LJ Cook, C Vacher, DG O’Donovan and DC Rubinsztein (2005) Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nature Medicine 6:672-677


• B Ravikumar, C Vacher, Z Berger, JE Davies, S Luo, LG Oroz, F Scaravilli, DF Easton, R Duden, CJ O’Kane, and DC Rubinsztein (2004) mTOR inhibition induces autophagy and reduces toxicity of the Huntington’s disease mutation in Drosophila and mouse models. Nature Genetics  36: 585-595

 

REVIEWS:

 

• DC Rubinsztein, G Mariño and G Kroemer (2011). Autophagy and Aging. Cell 146:682-695


• A Fleming, T Noda, T Yoshimori and DC Rubinsztein (2011) Chemical Modulators of Autophagy as Biological Probes and Potential Therapeutics. Nature Chemical Biology 7:9-17


• B Ravikumar, S Sarkar, JE Davies, M Futter, M Garcia-Arencibia, ZW Green-Thompson, WE Hochfeld, M Jimenez-Sanchez, VI Korolchuk, M Lichtenberg, S Luo, DCO Massey, FM Menzies, K Moreau, U Narayanan, M Renna, FH Siddiqi, BR Underwood, AR Winslow and DC Rubinsztein (2010) Regulation of mammalian autophagy in physiology and pathophysiology. Physiological Reviews 90:1383-1435


• DC Rubinsztein, JE Gestwicki, LO Murphy and DJ Klionsky (2007) Potential therapeutic applications of autophagy. Nature Reviews in Drug Discovery 6: 304-312


• DC Rubinsztein. (2006) The roles of intracellular protein degradation pathways in neurodegeneration. Nature 443:780-786