Cambridge Institute for Medical Research

Professor Linda Wicker

Professor Linda Wicker

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Key Publications

  • Dendrou, C.A., V. Plagnol, E. Fung, J. H. M. Yang, K. Downes, J. D. Cooper, S. Nutland, G. Coleman, M. Himsworth, M. Hardy, O. Burren, B. Healy, N. M. Walker, K. Koch, W. H. Ouwehand, J. R. Bradley, N. J. Wareham, J. A. Todd, and L. S. Wicker.  2009.  Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.  Nature Genetics, 41:1011-1015. 
  • Araki, M., D. Chung, S. Lui, D. B. Rainbow, G. Chamberlain, V. Garner, K. M. Hunter, L. Vijayakrishnan, L. B. Peterson, M. Oukka, A. H. Sharpe, R. Sobel, V. K. Kuchroo and L. S. Wicker.  2009.  Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in NOD mice. Journal of Immunology, 183: 5146 -5157.
  • Hamilton-Williams, E. H., X. Martinez, J. Clark, S. Howlett, K. M. Hunter, D. Rainbow, L. Wen, M. J. Shlomchik, J. D. Katz, G. F. Beilhack, L. S. Wicker* and L. A. Sherman*.  Expression of diabetes-associated genes by dendritic cells and CD4 T-cells drives the loss of tolerance in NOD mice. *share senior authorship.  Journal of Immunology, 183:1533-41.
  • Maier, L. M., S. Howlett, K. M. Hunter, J. Clark, J. M.M. Howson, J. A. Todd, L. S. Wicker.  2008.  NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.  Journal of Immunology, 181:7073-80.
  • Hunter, K., D. Rainbow, V. Plagnol, J. A. Todd, L. B. Peterson, and L. S. Wicker.  2007.  Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.  Journal of Immunology, 179:8341-8349
  • Ridgway, W.M., B. Healy, L.J. Smink, D. Rainbow and L.S. Wicker. 2007. New tools for defining the ‘genetic background’ of inbred mouse strains. Nature Immunology, 8:669-673.
  • Yamanouchi, J., D. Rainbow, P. Serra, S. Howlett, K. Hunter, V.E.S. Garner, A. Gonzalez-Munoz, J. Clark, R. Veijola, R. Cubbon, S.L. Chen, R. Rosa, A.M. Cumiskey, S. Gregory, J. Rogers, P.A. Lyons, B. Healy, L.J. Smink, J.A. Todd, L.B. Peterson, L.S. Wicker* and P. Santamaria*.  2007.  Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.  Nature Genetics, 39:329-37. *share senior authorship.
  • Kissler, S., P. Stern, K. Takahashi, K. Hunter, L. B Peterson and L. S. Wicker.  2006.  In vivo RNA interference demonstrates a role for Nramp1in modifying susceptibility to type 1 diabetes.  Nature Genetics, 38:479-483. 
  • Martinez, X., H. T. C. Kreuwel, W. L. Redmond, R. Trenney, K. Hunter, H. Rosen, N. Sarvetnick, L. S. Wicker, and L. A. Sherman.  2005.  CD8+ T cell tolerance in NOD mice is restored by insulin-dependent diabetes resistance alleles.  Journal of Immunology 175:1677-1685.
  • Pearson, T., P. Weiser, T. G. Markees,D. V. Serreze, L. S. Wicker,L. B. Peterson, A. M. Cumisky, L. D. Shultz, J. P. Mordes, A. A. Rossini, and D. L. Greiner.  2004.  Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.  Diabetes 53:1972-1978.
  • Ueda, H, J. M. M. Howson, L. Esposito, J. Heward, H. Snook, G. Chamberlain, D. B. Rainbow, K. M. D. Hunter, A. N. Smith, G. DiGenova, M. H. Herr, I. Dahlman, F. Payne, D. Smyth, C. Lowe, R. C. J. Twells, S. Howlett, B. Healy, S. Nutland, H. E. Rance, V. Everett, L. J. Smink, A. C. Lam, H. J. Cordell, N. M. Walker, C. Bordin, J. Hulme, C. Motzo, F. Cucca, J. F. Hess, M. L. Metzker, J. Rogers, S. Gregory, A. Allahabadia, R. Nithiyananthan, E. Tuomilehto-Wolf, J. Tuomilehto, P. Bingley, K. M. Gillespie, D. E. Undlien, K. S. Rønningen, C Guja, C. Ionescu-Tîrgovişte, D. A. Savage, D. J. Carson, A. P. Maxwell, C. C. Patterson, J A. Franklyn, D. G. Clayton, L. B. Peterson, L. S. Wicker, J. A. Todd and S. C. L. Gough.  2003.  Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.  Nature 423:506-511. 
  • Todd, J. A., T. J. Aitman, R. J. Cornall, S. Ghosh, J. R. S. Hall, C. M. Hearne, A. M. Knight, J. M. Love, M. A. McAleer, J.-B. Prins, N. Rodrigues, M. Lathrop, A. Pressey, N. H. DeLarato, L. B. Peterson, and L. S. Wicker.  1991.  Genetic analysis of autoimmune type 1 diabetes mellitus in mice.  Nature 351:542-547.
  • Wicker, L. S., B. J. Miller, L. Z. Coker, S. E. McNally, S. Scott, Y. Mullen and M. C. Appel.  1987.  Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. Journal of Experimental Medicine 165:1639-1654.