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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Human cytomegalovirus (HCMV) is a herpervirus which persistently infects over 60% of people worldwide. It is an important human pathogen and leading cause of congenital disease, affecting ~1/100...


Read more at: Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis

Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis

The study of rare genetic diseases can be a valuable way of acquiring new biological insights A new paper from joint first authors Ye Zhu and Motoki Fujimaki investigates the mechanisms by which...


Read more at: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford Progeria Syndrome

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford Progeria Syndrome

Deregulated mTOR signaling is implicated in many diseases, including neurodegeneration, as well as aging. Hutchinson-Gilford progeria syndrome (HGPS) is a rare sporadic autosomal dominant accelerated...


Read more at: The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Cells are challenged with a variety of stressful situations, one being the accumulation of unfolded proteins, which disrupt normal cellular functions and contribute to diseases like neurodegeneration...


Read more at: Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Monkeypox virus (MPXV), the cause of the mpox disease, is a zoonotic orthopoxvirus endemic in Central and West Africa. Since May 2022, thousands of cases of mpox have been reported in >90 non-...


Read more at: Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium

Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium

Obligate intracellular bacteria - those only capable of growth inside other living cells - have limited opportunities for horizontal gene transfer with other microbes due to their isolated...


Read more at: Evidence of a genetic background predisposing to complex regional pain syndrome type 1

Evidence of a genetic background predisposing to complex regional pain syndrome type 1

Complex regional pain syndrome type 1 (CRPS-1) is a rare, disabling and sometimes chronic disorder usually arising after a trauma. In a recent study, the Woods lab examined whether patients with this...


Read more at: The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Plasmodium vivax is the most geographically widespread cause of malaria, with nearly 3 billion people at risk of infection, mostly in Latin America and Asia. There is no approved vaccine for P. vivax...


Latest news

Read more at: CIMR at Cambridge Festival

CIMR at Cambridge Festival

18 March 2024

We had a great time taking part in the Big Biomedical Campus Day as part of the Cambridge Festival on Saturday 16th March. Researchers from CIMR spent the day at Cambridge Academy of Science &...


Read more at: ISAC/M student programme 2024

ISAC/M student programme 2024

27 February 2024

We had a great time last week welcoming a group of sixth form students to CIMR and MBU . The students came from schools in and around Cambridgeshire and gave up their half term holiday to spend the...


Read more at: Congratulations to new PI Dr Janin Lautenschläger

Congratulations to new PI Dr Janin Lautenschläger

19 December 2023

We are delighted that, following a newly-established process for candidates who have been at CIMR for some time and obtain independent funding, Dr Janin Lautenschläger has been formally approved by...


New CIMR publications

Weekes lab (Cell Host & Microbe 2024)

Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Rubinsztein lab (Nature Cell Biology 2024)

Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis 

Rubinsztein lab (Nature Cell Biology 2024)

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome

Ron lab (The EMBO Journal, 2023)
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Weekes lab (Nature Communications, 2023)
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Salje lab (mSphere, 2023)
Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium | mSphere (asm.org) 

Woods lab (Journal of Medical Genetics, 2023)
Evidence of a genetic background predisposing to complex regional pain syndrome type 1

Rayner/ Deane labs (Nature Communications, 2023)
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Rubinsztein lab (Developmental Cell, 2023)
Mammalian autophagosomes form from finger-like phagophores

Warren lab in a collaboration co-led with the Nangalia lab [Wellcome Sanger Institute; Cambridge Stem Cell Institute] and Kent lab [University of York] (Nature Communications, 2023)
Convergent somatic evolution commences in utero in a germline ribosomopathy 

Weekes lab (Cell Reports, 2023)
Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity

Weekes lab in collaboration with Gewurz lab [Harvard Medical School] (Molecular Cell, 2023)
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

Griffiths lab (Science, 2023)
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse

Rubinsztein lab (Neuron, 2023)
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Deane lab (PNAS, 2023)
Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

Warren lab (Nucleic Acid Res., 2023)
Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution

Gershlick lab (J. Cell Biology, 2023)
The exocyst complex is an essential component of the mammalian constitutive secretory pathway

Read lab (Acta Crystallographica Section D, 2023)
Likelihood-based docking of models into cryo-EM maps

Ron lab in collaboration with Elisa De Franco and Andrew Hattersley [University of Exeter] (EMBO Mol. Med 2023)
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP

 

 

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