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Postgraduate Open Day

New publications

Rayner lab (Nature, 2020)
Red blood cell tension protects against severe malaria in the Dantu blood group

Maxwell lab (Nature Immunology, 2020)
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development

Owen lab in collaboration with the Briggs lab, LMB (Science Advances, 2020)
Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles

Weekes lab (PNAS, 2020)
Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor

Woods lab (Cell Reports, 2020)
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit

Deane lab (Nature Communications, 2020)
The receptor PTPRU is a redox sensitive pseudophosphatase

Rubinsztein lab (Nature Communications, 2020)
Leucine regulates autophagy via acetylation of the mTORC1 component raptor

Rubinsztein lab in collaboration with the Goldberg lab, Harvard (PNAS, 2020)
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Griffiths lab (eLife, 2020)
Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

Buss lab (Journal of Cell Science, 2020)
OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion

Rubinsztein lab (Developmental Cell, 2020)
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy

Buss lab (Biology of Reproduction, 2020)
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis

Weekes lab (Scientific Reports, 2020)
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes

Buss lab (Traffic, 2020)
Ultrastructural insights into pathogen clearance by autophagy

Read lab (Acta Crystallographica Section D, 2020)
Measuring and Using Information Gained by Observing Diffraction Data

Read lab (Acta Crystallographica Section D, 2020)
Factors influencing estimates of coordinate error for molecular replacement

Ron lab (eLife, 2019)
Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Weekes lab (eLife, 2019)
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

Rubinsztein lab (eLife, 2019)
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

Ron lab (eLife, 2019)
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

Griffiths lab (Journal of Clinical Investigation, 2019)
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

Reid lab (Frontiers in Neuroscience, 2019)
Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function

Deane lab (Wellcome Open Research, 2019)
The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading

Reid lab (Cellular and Molecular Life Sciences, 2019)
ESCRT‑III‑associated proteins and spastin inhibit protrudin‑dependent polarised membrane traffic

Ron lab (EMBO Journal, 2019)
An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

Robinson lab (Traffic, 2019)
Fast and cloning‐free CRISPR/Cas9‐mediated genomic editing in mammalian cells

Weekes lab (Communications Biology, 2019)
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations

St George-Hyslop lab (Cell, 2019)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Siniossoglou lab (Developmental Cell, 2019)
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization

Weekes lab (Cell Metabolism, 2019)
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

Warren lab (Blood, 2019)
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.

Warren lab (eLife, 2019)
Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

Weekes lab (Cell Reports, 2019)
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

Rubinsztein lab (Nature Communications, 2019)
Felodipine ameliorates neurodegeneration in mice

Sharpe lab (eLife, 2019)
The receptor PTPRK selectively dephosphorylates junctional regulators

Ron lab (Nature Comm, 2019)
MANF anatagonizes nucleotide exchange by the enodplasmic reticulum chaperone BiP