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Nathan web 2018

2-OG dependent dioxygenases as oxygen/metabolite sensors. 2-OG-dependent dioxygenases are a diverse group of around 60 enzymes involved in processes such as collagen synthesis, ribosome modifications, HIF signalling and chromatin remodelling. Our studies focus on 2-OG dependent dioxygenases involved in HIF signalling and chromatin remodelling: PHDs- prolyl hydroxylases, FIH – factor inhibiting HIF, TETs - ten-eleven translocation enzymes (hydroxylate 5-methylcytosine), and JHDMs - Jumonji-domain containing histone demethylases.
Nathan web 2018
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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease






New publications


Griffiths lab (Nature Immunol. 2018)

Single cell insights into T cell killing capacity.


Larrieu lab (Sci. Signalling 2018)

Transportin-1 targeted in progeria.


Siniossoglou lab (Dev. Cell 2018)

A conserved mechanism for membrane phospholipid sensing.


Larrieu lab (Nature Comm. 2018)

NAT10 inhibition increases healthspan of HGPS mice.


St George-Hyslop lab (Cell 2018)

Phase separation control of FUS in neurodegeneration.


Ron lab (J. Biol. Chem. 2018)

Inhibitor sensitivity of the eIF2a phosphatase revisited.


Marciniak lab (ASC Nano. 2018)

Measuring microviscosity dynamics inside organelles.


Rubinsztein lab (Dev. Cell 2018)

Recycling endosomes as a novel platform for autophagosome formation.


Ron and Warren labs (Science 2018)

CryoEM analysis of integrated stress response.


Nathan and Lehner labs (EMBO Rep. 2018)

Overlapping E3 ligase function in the ER.


Robinson lab (PLoS Biol. 2018)

AP-5 in endosome-to-Golgi transport.