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Cambridge Institute for Medical Research


A collaborative study between the groups of Drs Michal Minczuk, Alex Whitworth at the MBU and Alan Warren at the CIMR, published in Nature Communications, reports the identification of a critical checkpoint during assembly of the mitochondrial large subunit that is essential for the maintenance of mitochondrial homeostasis. The study uncovers how the MRM2 protein regulates the generation of new mitoribosomes and provides a mechanistic understanding of mitochondrial disorders associated with mutations in this protein. This research study, led by Dr Michal Minczuk, involved collaborators at the University of Cambridge, The Weizmann Institute of Science (Israel), and STORM Therapeutics (Cambridge).