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A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum
Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
The intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility
Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis
Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease
Transferrin Receptor controls both autophagosome formation and closure via Phosphatidylinositol 3-phosphate synthesis
Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
Alpha-synuclein mutations mislocalise cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 anti-trypsin deficiency
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
VAMP2 regulates phase separation of α-synuclein
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle
The ALBORADA Drug Discovery Institute
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Intranet (CIMR only)
Dr Alex Nicholson
Cambridge Institute for Medical Research
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Intranet (CIMR only)
Dr Alex Nicholson
Research Associate, Deane Lab
asn33@cam.ac.uk
01223 746659
