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Cambridge Institute for Medical Research



I studied biochemistry in Trinity College Dublin, and obtained my PhD from the University of Cambridge (supervised by Prof. Jeremy Saklatvala of the Babraham Institute and Kennedy Instititute of Rheumatology). I held postdoc positions at the Inositide Laboratory, Babraham and with Prof. Ken Siddle in the Dept. of Clinical Biochemistry / Institute of Metabolic Science where I also secured a Diabetes UK RD Lawrence Fellowship. Outside academia I have worked in the biotech sector and in medical research charities, as Director of Research at Alzheimer's Research UK, followed by Myeloma UK.  I am a Trustee of Alzheimer's Brain Bank UK.


Key publications: 

Mitchell, S.; Ridley, S. H.; Sancho, R. M.; Norton, M. (2017) Journal of Public Health (20) E275: The future of dementia risk reduction research: barriers and solutions

Snyder, Heather M.; Shineman, Diana W.; Friedman, Lauren G.; Hendrix, James A.; Khachaturian, Ara; Le Guillou, Ian; Pickett, James; Refolo, Lorenzo; Sancho, Rosa M.; Ridley, Simon H. (2016) Alzheimer’s and Dementia (12) 1177: Guidelines to improve animal study design and reproducibility for Alzheimer's disease and related dementias: For funders and researchers

Sancho, Rosa M.; Cox, Carla J.; Phipps, Laura E.; Ridley, Simon H. (2016) Alzheimer’s Research and Therapy (8) 35: Alzheimer's Research UK 2016 Conference report

Sancho, Rosa M.; Cox, Carla J.; Ridley, Simon H.; Phipps, Laura E.; Karran, Eric (2015) Alzheimer’s Research and Therapy (7) 52: Report from the Alzheimer's Research UK Conference 2015

Sancho, Rosa M.; Ridley, Simon H.; Phipps, Laura E.; Karran, Eric (2014) ) Alzheimer’s Research and Therapy (6) 40: Basic to translational research in dementia: meeting report from the Alzheimer's Research UK Conference 2014

Spriggs, Keith A.; Cobbold, Laura C.; Ridley, Simon H.; Coldwell, Mark; Bottley, Andrew; Bushell, Martin; Willis, Anne E.; Siddle, Kenneth (2009) Nucleic Acids Research (37) 5881: The human insulin receptor mRNA contains a functional internal ribosome entry segment

Boyle, K. B.; Hadaschik, D.; Virtue, S.; Cawthorn, W. P.; Ridley, S. H.; O'Rahilly, S.; Siddle, K. (2009) Cell Death And Differentiation (16) 782: The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation

Lam, Daniel D.; Przydzial, Magdalena J.; Ridley, Simon H.; Yeo, Giles S. H.; Rochford, Justin J.; O'Rahilly, Stephen; Heisler, Lora K. (2008) Endocrinology (149) 1323: Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors

Hill, A*; Ridley, SH*; Esser, D; Oldroyd, RG; Cullen, MJ; Kareclas, P; Gallagher, S; Smith, GP; Richards, SJ; White, J; Smith, RAG; Hillmen, P (2006) Blood (107) 2131: Protection of erythrocytes from human complement-mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy

Krugmann, S*; Anderson, KE*; Ridley, SH*; Risso, N; McGregor, A; Coadwell, J; Davidson, K; Eguinoa, A; Ellson, CD; Lipp, P; Manifava, M; Ktistakis, N; Painter, G; Thuring, JW; Cooper, MA; Lim, ZY; Holmes, AB; Dove, SK; Michell, RH; Grewal, A; Nazarian, A; Erdjument-Bromage, H; Tempst, P; Stephens, LR; Hawkins, PT (2002) Molecular Cell (9) 95: Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

Ridley, SH; Ktistakis, N; Davidson, K; Anderson, KE; Manifava, M; Ellson, CD; Lipp, P; Bootman, M; Coadwell, J; Nazarian, A; Erdjument-Bromage, H; Tempst, P; Cooper, MA; Thuring, JWJF; Lim, ZY; Holmes, AB; Stephens, LR; Hawkins, PT (2001) Journal of Cell Science (114) 3991: FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments

Anderson, KE; Lipp, P; Bootman, M; Ridley, SH; Coadwell, J; Ronnstrand, L; Lennartsson, J; Holmes, AB; Painter, GF; Thuring, J; Lim, ZY; Erdjument-Bromage, H; Grewal, A; Tempst, P; Stephens, LR; Hawkins, PT (2000) Current Biology (10) 1403: DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma membrane recruitment and endocytosis upon cell stimulation

Cockerill, GW; Saklatvala, J; Ridley, SH; Yarwood, H; Miller, NE; Oral, B; Nithyanathan, S; Taylor, G; Haskard, DO (1999) Arteriosclerosis Thrombosis and Vascular Biology (19) 910: High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2

Ridley, SH; Dean, JLE; Sarsfield, SJ; Brook, M; Clark, AR; Saklatvala, J (1998) FEBS Letters (439) 75: A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA

Ridley, SH; Sarsfield, SJ; Lee, JC; Bigg, HF; Cawston, TE; Taylor, DJ; DeWitt, DL; Saklatvala, J (1997) Journal of Immunology (158) 3165: Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase - Regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels



Scientific Research Strategy Manager

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Darwin College