p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
A new paper from the Rubinsztein lab, led by Lidia Wrobel, describes how mutations in the AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), can contribute to diseases such as...
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle
Lysosomes function as the terminal degradative compartment of a cell’s endocytic and autophagic pathways, and as a multifunctional signalling hub integrating the cell’s response to nutrient status...
The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic
Adaptor protein (AP) complexes are an ancient family of heterotetramers, which select cargo for packaging into transport vesicles at various locations in the cell. The AP-1 adaptor is arguably the...
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
The pleural lining of the thorax regulates local immunity and wound healing. Disruption of these functions induces fibrosis and in the case of exposure to asbestos, chronic irritation can cause...
Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly
Human cytomegalovirus (HCMV) is a herpervirus which persistently infects over 60% of people worldwide. It is an important human pathogen and leading cause of congenital disease, affecting ~1/100...
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis
The study of rare genetic diseases can be a valuable way of acquiring new biological insights A new paper from joint first authors Ye Zhu and Motoki Fujimaki investigates the mechanisms by which...
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford Progeria Syndrome
Deregulated mTOR signaling is implicated in many diseases, including neurodegeneration, as well as aging. Hutchinson-Gilford progeria syndrome (HGPS) is a rare sporadic autosomal dominant accelerated...
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells
Cells are challenged with a variety of stressful situations, one being the accumulation of unfolded proteins, which disrupt normal cellular functions and contribute to diseases like neurodegeneration...
CIMR PI to co-lead The National Translational Centre for Rare Respiratory Diseases
29 April 2024
The medical research charity LifeArc has announced the launch of four new Translational Centres for rare diseases. One of these, The National Translational Centre for Rare Respiratory Diseases, will...
Prof David Rubinsztein receives American Academy of Neurology Movement Disorders Research Award
22 April 2024
CIMR are delighted that Prof David Rubinsztein has been awarded the 2024 Movement Disorders Research Award by the American Academy of Neurology. This award recognizes an individual for outstanding...
Dr Jennifer Dickens awarded Action for Pulmonary Fibrosis Mike Bray Fellowship
11 April 2024
Lung conditions are the third biggest killer in the UK, but receive relatively small amounts of research funding. Less than 2% of public medical research funding goes to respiratory disease research...
