Alpha-synuclein mutations mislocalise cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterised by motor dysfunction, neuronal loss in different regions of the brain, and the accumulation of α-...
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Phase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. Recent work has raised the intriguing prospect that phase...
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 anti-trypsin deficiency
Chronic liver disease (CLD) leading to cirrhosis accounts for 1 in 25 deaths globally. Significant numbers of CLD cases relate to germline genetic disorders, including haemochromatosis and alpha-1...
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Appropriate cellular recognition of viruses is essential for the generation of an effective innate and adaptive immune response. Viral sensors and their downstream signaling components thus provide a...
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
Malaria parasites are highly divergent from model eukaryotes. Large-scale genome engineering methods effective in model organisms are frequently inapplicable, and systematic studies of gene function...
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD)...
Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion
Biogenesis of membrane-bound organelles involves the synthesis, remodeling, and degradation of their constituent phospholipids. How these pathways regulate organelle size remains poorly understood...
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Tauopathies are neurodegenerative diseases which show intracellular accumulation and aggregation of tau protein. In diseases such as Pick's disease, progressive supranuclear palsy, corticobasal...
Risk of punctured lung from a faulty gene implicated in rare lung disease is almost 100 times higher than previous estimate
17 April 2025
New research from Prof Stefan Marciniak and colleagues has shown that as many as one in 3,000 people could be carrying a faulty gene which significantly increases their risk of suffering a punctured...
We had a great day at Cambridge Festival's Biomedical Campus family day held at Cambridge Academy for Science & Technology. There were a record number of visitors who came to meet researchers...
During February half term we welcomed the latest cohort of sixth-form students to our Inspiring Scientists programme (ISAC/M) , run in collaboration with the MRC MBU and St Catharine’s College . This...
