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Cambridge Institute for Medical Research

Department A-Z

Our strategy

We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

The Luzio lab show in Current Biology that endolysosomes are the main site of intracellular acid hydrolase cleavage activity, and that they are linked with terminal storage lysosomes through a dynamic regeneration cycle.

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Research advances

In Nature Communications, the Lehner lab compare genome-wide CRISPR/Cas9-mediated forward genetic screens with gene-trap mutagenesis screens in haploid human cells, identifying new factors that control mammalian ER-associated degradation of MHC class I molecules.

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CamAWiSE careers event

Hayley Sharpe was among the speakers at the LMB Cambridge AWiSE event this month, providing career advice and insights into key transitions for early stage researchers.

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Achievement award

Congratulations to Peter St George-Hyslop, whose research into the basis of Alzheimer's disease has been recognized by the Weston Brain Institute Outstanding Achievement Award.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

New publications

Luzio lab (Curr. Biol. 2016)

Re-evaluating the lysosome regeneration cycle.


Lehner lab (Traffic 2016)

Trafficking control of tetherin.


Rubinsztein lab (Nature Comm. 2016)

Autophagy-lysosome dysfunction in Parkinson's disease.


Lehner lab (Nature Comm. 2016)

Forward-genetic screens of mammalian ER-associated degradation.


Deane lab (Traffic 2016)

Uncovering Krabbe Disease pathogenesis.


Smith lab (PLoS Genet. 2016)

eQTL mapping of immune disease.


Ron lab (eLife 2016)

AMPylation of BiP ER chaperone.