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Cambridge Institute for Medical Research

Department A-Z

Our strategy

We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

In Cell Reports, the Nathan lab show that the proteasome can distinguish between atypical ubiquitin chains of distinct topology. Whereas the proteasome can bind and degrade heterotypic lysine-11-linked chains, it cannot bind significantly to homotypic lysine-11-linked chains.

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Research advances

In Science, the Lehner lab use a forward-genetic screen in near-haploid human cells to identify the Human Silencing Hub (HUSH) complex as a regulator of position-effect variegation. Through recruitment to genomic loci rich in H3K9me3, the complex promotes maintenance of transcriptional silencing.

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Final opportunity for October 2015 PhD programme placement

Apply here for a final place available for October 2015 entry on the Cambridge University Wellcome Trust 1+3 PhD programme in Infection, Immunity and Inflammation.

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SUSTAIN programme award

Congratulations to Janet Deane, who is among 20 female researchers selected for the SUSTAIN programme. Run by the Academy of Medical Sciences, this scheme aims to help more women achieve senior positions.

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Novel Thoughts

As part of a film series about the reading habits of scientists, Guy Pearson from the Reid lab shares his insights from Thomas Hardy's Under the Greenwood Tree, and its parallels with his experience in research.

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Insights into pain perception

The Guardian outlines the discovery by Geoff Woods that PRDM12 mutation can result in congenital insensitivity to pain (CIP) and the implications this may have in the longer term for development of new pain relief methods.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

New publications

Smith lab (Nature 2015)

T cell exhaustion and clinical outcome.

Lehner lab (Science 2015)

HUSH complex maintains transcriptional silencing.

Marciniak lab (Plos Path. 2015)

Pseudomonas induction of ER stress.

Luzio lab (Traffic 2015)

Mammalian HOPS complex control of lysosome fusion.

Woods lab (Nature Genetics 2015)

PRDM12 regulates congenital insensitivity to pain.

Göttgens lab (Cell Stem Cell 2015)

Combined single cell analysis of blood stem cells.

Griffiths lab (Immunity 2015)

The immune synapse in 4D.


 Owen lab (Dev. Cell 2015)

CALM driving and sensing membrane curvature.