We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.
In Cell Metabolism, the Nathan lab use a forward genetic screen in human cells to reveal a novel metabolic pathway by which hypoxia-inducible factor (HIF) stability is controlled in aerobic conditions, highlighting interplay between oxygen and metabolic sensing.
A collaboration between the lab of Lucy Raymond, UCL Great Ormond Street Institute of Child Health and the NIHR Rare Disease Bioresource has identified a new genetic movement disorder (KMT2B-related dystonia) that can be treated with deep brain stimulation.
A new strategy that might be used to treat haemophilia, arising from a collaboration between the Huntington lab and Trevor Baglin at Addenbrooke's Hospital, is now being progressed by the start-up company ApcinteX.