We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.
In Cell Reports, the Nathan lab show that the proteasome can distinguish between atypical ubiquitin chains of distinct topology. Whereas the proteasome can bind and degrade heterotypic lysine-11-linked chains, it cannot bind significantly to homotypic lysine-11-linked chains.
In Science, the Lehner lab use a forward-genetic screen in near-haploid human cells to identify the Human Silencing Hub (HUSH) complex as a regulator of position-effect variegation. Through recruitment to genomic loci rich in H3K9me3, the complex promotes maintenance of transcriptional silencing.
Congratulations to Janet Deane, who is among 20 female researchers selected for the SUSTAIN programme. Run by the Academy of Medical Sciences, this scheme aims to help more women achieve senior positions.
As part of a film series about the reading habits of scientists, Guy Pearson from the Reid lab shares his insights from Thomas Hardy's Under the Greenwood Tree, and its parallels with his experience in research.
The Guardian outlines the discovery by Geoff Woods that PRDM12 mutation can result in congenital insensitivity to pain (CIP) and the implications this may have in the longer term for development of new pain relief methods.
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