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Cambridge Institute for Medical Research

Department A-Z

Our strategy

We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

The Marciniak and Ron labs have together shown that G-actin stabilizes the PP1-PPP1R15 holophosphatase for dephosphorylation of eukaryotic translation initiation factor 2 (eIF2a), thereby linking actin dynamics with modulation of the integrated stress response. In a second study with the Read lab, they have determined that G-actin provides substrate specificity to the holophosphatase by contributing to formation of the active site for eIF2a docking.

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Research advances

In collaboration with Microsoft Research and the Dept of Biochemistry, the Göttgens lab show in Nature Biotechnology that single-cell analysis can be coupled with computational modelling to reveal the transcriptional networks driving blood cell development.

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The University spin-out company XO1 Ltd, which Jim Huntington is co-founder and director of, has been acquired by the Johnson & Johnson pharmaceutical company Janssen. They will continue the pre-clinical development of ichorcumab, a synthetic antibody against thrombin that promotes anti-coagulation without increased bleeding risk.

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2015 Commonwealth Day Reception

Chris Hill (Deane and Read labs) represented young UK scientists at the 2015 Commonwealth Day Reception this month. This event, which was attended by HM The Queen and HRH The Duke of Edinburgh, celebrated the capacity, contribution and potential of young people and followed on from the inaugural Commonwealth Science Conference that Chris attended last year in Bangalore (Commonwealth Secretariat photo by Richard Lewis).

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Wellcome Images 2015

Congratulations to Nele Dieckmann (Griffiths lab, CIMR) and Nicola Lawrence (Gurdon Institute), whose super-resolution image of a immune cell attacking its target has been selected for the finals of the Wellcome Images 2015 competition and highlighted by the BBC.

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Cambridge Drug Discovery Institute

Alzheimer's Research UK has announced an £30m Drug Discovery Alliance, which will include a new institute on the Cambridge Biomedical Campus with CIMR Deputy Director David Rubinsztein as its academic lead. Its primary focus will be on the development of new treatments for Alzheimer's and other causes of dementia.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

New publications

Deane and Read labs (Chem. Sci. 2015)

Pharmacological chaperones for Krabbe disease.

WT/JDRF Diabetes and Inflammation lab (Trials 2015).

Recruitment strategy for DILT1D trial.

Marciniak and Ron labs (eLife 2015)
G-actin modulation of the integrated stress response.

Ron, Read and Marciniak labs (eLife 2015)
G-actin provides substrate specificity for PP1 holophosphatase.

Green lab (N. Engl. J. Med. 2015)

Mutation order importance in myeloproliferative neoplasms.