We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.
The Rubinsztein lab report in Molecular Cell that phosphatidylinositol 5-phosphate (PI(5)P) promotes autophagosome biogenesis and that it can sustain autophagy when PI(3)P is depleted. This highlights a novel cytoplasmic role for PI(5)P as a regulator of non-canonical autophagy.
The Seaman lab reveal in Cell Reports the findings of their genome-wide siRNA screen for regulators of endosome-to-Golgi retrieval, a process implicated in neurodegenerative disease. Among >80 hits, they find a new role for three multipass membrane-spanning proteins.
Congratulations to Eoin McKinney in the Smith lab, who has been awarded a Wellcome Trust Intermediate Clinical Fellowship and a Wellcome-Beit Prize Fellowship, the latter of which recognizes just four outstanding biomedical researchers each year.
A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease
you use our web site. We may also use external analysis systems which may
set additional cookies to perform their analysis.These cookies (and any
others in use) are detailed in our site privacy and cookie policies and are
integral to our web site. You can delete or disable these cookies in your
web browser if you wish but then our site may not work correctly.