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Cambridge Institute for Medical Research

Department A-Z

Our strategy

We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

Annexin A2 is a novel mTOR-independent modulator of autophagy, reports the Rubinsztein lab in Nature Communications. Transcriptional upregulation of this actin-nucleating factor is important for actin-mediated sorting of ATG9A during autophagosome formation.

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Research advances

In Cell Reports, the Nathan lab show that the proteasome can distinguish between atypical ubiquitin chains of distinct topology. Whereas the proteasome can bind and degrade heterotypic lysine-11-linked chains, it cannot bind significantly to homotypic lysine-11-linked chains.

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Young Investigator Meeting UK

The first Young Investigator Meeting (YIM) UK will take place on the Cambridge Biomedical Campus on September 9th. Co-organized by early career CIMR researchers and IndiaBioscience, this open meeting aims to promote networking among young scientists as well as new international collaborations.

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Final opportunity for October 2015 PhD programme placement

Apply here for a final place available for October 2015 entry on the Cambridge University Wellcome Trust 1+3 PhD programme in Infection, Immunity and Inflammation.

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SUSTAIN programme award

Congratulations to Janet Deane, who is among 20 female researchers selected for the SUSTAIN programme. Run by the Academy of Medical Sciences, this scheme aims to help more women achieve senior positions.

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Insights into pain perception

The Guardian outlines the discovery by Geoff Woods that PRDM12 mutation can result in congenital insensitivity to pain (CIP) and the implications this may have in the longer term for development of new pain relief methods.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

New publications

Rubinsztein lab (Nature Comm. 2015)

Autophagy promoted by Annexin A2.

Smith lab (Nature 2015)

T cell exhaustion and clinical outcome.

Lehner lab (Science 2015)

HUSH complex maintains transcriptional silencing.

Marciniak lab (Plos Path. 2015)

Pseudomonas induction of ER stress.

Luzio lab (Traffic 2015)

Mammalian HOPS complex control of lysosome fusion.

Woods lab (Nature Genetics 2015)

PRDM12 regulates congenital insensitivity to pain.

Göttgens lab (Cell Stem Cell 2015)

Combined single cell analysis of blood stem cells.

Griffiths lab (Immunity 2015)

The immune synapse in 4D.