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Cambridge Institute for Medical Research

Department A-Z

Our strategy

We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

A study from the Owen lab led by Bernard Kelly has determined a new structure of the adaptor AP2 that reveals a clathrin-binding β2 hinge region. Using this, they show that AP2 regulates clathrin polymerization, and thus clathrin-mediated endocytosis, through a membrane-activated switch.

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Research advances

The Lehner and Nathan labs report in the Journal of Cell Biology that specific tail-anchored proteins can be cleaved within the membrane by signal peptide peptidase (SPP), and thereby targeted for turnover.

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News

Margaret Robinson outlines her research goals in the Wellcome Trust Researcher Spotlight blog this month.

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News

David Rubinsztein has been included in a list released by Thomson Reuters of the most highly cited researchers worldwide across 21 fields of the sciences and social sciences. This is based on his studies published between 2002 and 2012 in two categories of science (Biology & Biochemistry and Molecular Biology & Genetics), which have provided a "mark of exceptional impact".

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News

In an interview with Type 1 Discovery magazine, Frank Waldron-Lynch outlines the defining features of the DILT1D clinical trial being conducted by the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, and the successful completion of its patient recruitment a year ahead of schedule.

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New fellows

Congratulations to Randy Read and David Ron, who have been elected as Fellows of the Royal Society, and to Bertie Göttgens, who has been elected as a Fellow of the Academy of Medical Sciences.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease






New publications

Ron lab (eLife 2014)

Reassessing the role of reduced ER glutathione.

 

Owen lab (Science 2014)

AP2 drives clathrin polymerization in endocytosis.


Lehner and Nathan labs (JCB 2014)

SPP-mediated intramembrane cleavage of tail-anchored proteins.


The JDRF/Wellcome Trust Diabetes and Inflammation lab (BMJ Open 2014)

The study design for the DILT1D trial.