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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a disorder in which aberrant vascular remodelling raises pressures in the pulmonary vasculature, causing right heart failure. Affected young adults often...


Read more at: p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

A new paper from the Rubinsztein lab, led by Lidia Wrobel, describes how mutations in the AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), can contribute to diseases such as...


Read more at: Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

Lysosomes function as the terminal degradative compartment of a cell’s endocytic and autophagic pathways, and as a multifunctional signalling hub integrating the cell’s response to nutrient status...


Read more at: The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

Adaptor protein (AP) complexes are an ancient family of heterotetramers, which select cargo for packaging into transport vesicles at various locations in the cell. The AP-1 adaptor is arguably the...


Read more at: Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

The pleural lining of the thorax regulates local immunity and wound healing. Disruption of these functions induces fibrosis and in the case of exposure to asbestos, chronic irritation can cause...


Read more at: Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Human cytomegalovirus (HCMV) is a herpervirus which persistently infects over 60% of people worldwide. It is an important human pathogen and leading cause of congenital disease, affecting ~1/100...


Read more at: Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis

Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis

The study of rare genetic diseases can be a valuable way of acquiring new biological insights A new paper from joint first authors Ye Zhu and Motoki Fujimaki investigates the mechanisms by which...


Read more at: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford Progeria Syndrome

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford Progeria Syndrome

Deregulated mTOR signaling is implicated in many diseases, including neurodegeneration, as well as aging. Hutchinson-Gilford progeria syndrome (HGPS) is a rare sporadic autosomal dominant accelerated...


Latest news

Read more at: Janet Deane wins teaching award

Janet Deane wins teaching award

20 June 2024

We're delighted to announce that Janet Deane has been awarded the Inclusive Practise award at the Student-Led Teaching Awards (run by the Cambridge Students' Union). Nominated and selected by...


Read more at: CIMR PI to co-lead The National Translational Centre for Rare Respiratory Diseases

CIMR PI to co-lead The National Translational Centre for Rare Respiratory Diseases

29 April 2024

The medical research charity LifeArc has announced the launch of four new Translational Centres for rare diseases. One of these, The National Translational Centre for Rare Respiratory Diseases, will...


Read more at: Prof David Rubinsztein receives American Academy of Neurology Movement Disorders Research Award

Prof David Rubinsztein receives American Academy of Neurology Movement Disorders Research Award

22 April 2024

CIMR are delighted that Prof David Rubinsztein has been awarded the 2024 Movement Disorders Research Award by the American Academy of Neurology. This award recognizes an individual for outstanding...


New CIMR publications

Marciniak lab (Human Molecular Genetics 2024)

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension | Human Molecular Genetics | Oxford Academic (oup.com) 

Reiner Schulte (contributor, Springer Protocols 2024) 

Practicalities of Cell Sorting

Rubinsztein lab (Science Advances 2024)

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

Luzio lab (Molecular Biology of the Cell 2024)

Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

Robinson lab (Journal of Cell Biology 2024)

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

Marciniak lab, in collaboration with Prof Rintoul (Royal Papworth Hospital) & Matthew Garnett (Sanger Institute) (European Respiratory Journal 2024)

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

Weekes lab (Cell Host & Microbe 2024)

Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Rubinsztein lab (Nature Cell Biology 2024)

Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis 

Rubinsztein lab (Nature Cell Biology 2024)

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome

Ron lab (The EMBO Journal, 2023)
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Weekes lab (Nature Communications, 2023)
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Salje lab (mSphere, 2023)
Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium | mSphere (asm.org) 

Woods lab (Journal of Medical Genetics, 2023)
Evidence of a genetic background predisposing to complex regional pain syndrome type 1

Rayner/ Deane labs (Nature Communications, 2023)
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Rubinsztein lab (Developmental Cell, 2023)
Mammalian autophagosomes form from finger-like phagophores

Warren lab in a collaboration co-led with the Nangalia lab [Wellcome Sanger Institute; Cambridge Stem Cell Institute] and Kent lab [University of York] (Nature Communications, 2023)
Convergent somatic evolution commences in utero in a germline ribosomopathy 

Weekes lab (Cell Reports, 2023)
Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity

Weekes lab in collaboration with Gewurz lab [Harvard Medical School] (Molecular Cell, 2023)
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

Griffiths lab (Science, 2023)
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse

Rubinsztein lab (Neuron, 2023)
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Deane lab (PNAS, 2023)
Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

Warren lab (Nucleic Acid Res., 2023)
Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution

Gershlick lab (J. Cell Biology, 2023)
The exocyst complex is an essential component of the mammalian constitutive secretory pathway

Read lab (Acta Crystallographica Section D, 2023)
Likelihood-based docking of models into cryo-EM maps

Ron lab in collaboration with Elisa De Franco and Andrew Hattersley [University of Exeter] (EMBO Mol. Med 2023)
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP

 

 

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