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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Mitochondria set the pace of killing

Mitochondria set the pace of killing

Cytotoxic T lymphocytes (CTLs) recognise and destroy cells which are infected with viruses or are cancerous. This latter property puts them at the heart of new immunotherapies transforming cancer...

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Read more at: A structure-based understanding of how the Integrated Stress Response is switched off

A structure-based understanding of how the Integrated Stress Response is switched off

Like many key biological pathways, the Integrated Stress Response (ISR) is carefully regulated. A known molecular trigger for the ISR is the stress-induced phosphorylation of the α-subunit of...

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Read more at: New strides made in solving protein structures

New strides made in solving protein structures

There have been some major developments in computational tools to predict the 3D structures of proteins. Nature recently published the details of AlphaFold2 , the machine-learning product of Google...

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Read more at: Somatic genetic rescue in a rare disease

Somatic genetic rescue in a rare disease

Ribosomopathies such as Shwachman-Diamond syndrome (SDS) are rare diseases caused by defects in ribosome assembly. A new international study co-led by Prof. Alan Warren (CIMR) and Prof. Patrick Revy...

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Read more at: Structural and mechanistic insights into a molecular chaperone

Structural and mechanistic insights into a molecular chaperone

BiP is a molecular chaperone of the endoplasmic reticulum (ER), playing a tightly-regulated role in protein folding and the Unfolded Protein Response. Under normal conditions, a substantial fraction...

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Latest news

Read more at: Recognition for highly-cited CIMR researcher

Recognition for highly-cited CIMR researcher

18 November 2021

Professor David Rubinsztein FRS has been highlighted by Clarivate as a ‘Highly Cited Researcher’ in 2021. This is due to his highly-cited papers which rank in the top 1% by citations for field and...

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Read more at: Postdoc Appreciation Week 2021

Postdoc Appreciation Week 2021

20 September 2021

With over 70 postdocs at CIMR, we support Postdoc Appreciation Week (September 20th – 24th) and want to acknowledge the great work postdocs do as part of the bedrock of the global science effort –...

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Read more at: CIMR involvement in a new widening participation initiative for students

CIMR involvement in a new widening participation initiative for students

16 July 2021

Experience Postgrad Life Sciences is a residential summer internship programme at Cambridge for undergraduate students of biological / biomedical science subjects who may not otherwise be able to...

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New CIMR publications

Deane lab (Contact, 2021)
A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins

Weekes lab (eLife, 2021)
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

Griffiths lab (Science, 2021)
Mitochondrial translation is required for sustained killing by cytotoxic T cells

Ron lab (Nature Structural & Molecular Biology, 2021)
Higher-order phosphatase–substrate contacts terminate the integrated stress response

Read lab (Proteins, 2021)
Assessing the utility of CASP14 models for molecular replacement

Warren lab in collaboration with the Revy lab, Paris (Nature Communications, 2021)
Somatic genetic rescue of a germline ribosome assembly defect

Ron lab (Nature Communications, 2021)
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

Griffiths lab (Journal of Cell Biology, 2021)
Signal strength controls the rate of polarization within CTLs during killing

Rayner lab (PLoS Pathogens, 2021)
Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

Rubinsztein lab (Developmental Cell, 2021)
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

Marciniak lab (European Respiratory Journal, 2021)
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant

Ron & Marciniak labs (Cell Reports, 2021)
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Luzio lab (Journal of Cell Science, 2021)
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway

Rubinsztein lab
(Nature Communications, 2021)
α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

(Nature Chemical Biology, 2021)
VCP/p97 regulates Beclin-1-dependent autophagy initiation 

Weekes lab (Frontiers in Cellular and Infectious Microbiology, 2021)
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics

Robinson lab (Journal of Cell Biology, 2021)
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex

 

 

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