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Cambridge Institute for Medical Research

Department A-Z

Our strategy

CIMR is a unique partnership between basic and clinical research, aiming to understand the cellular basis of disease. Our goal is to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

The Larrieu (CIMR) and Jackson groups (Gurdon Institute) reveal in Science Signalling that the transportin-1 nuclear import pathway is an essential target of NAT10 acetyltransferase in progeria and ageing.

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Research advances

The Siniossoglou group has collaborated with the Savage group (Institute of Metabolic Sciences) to elucidate a conserved biophysical mechanism for phospholipid sensing by the PCYT1 enzyme at the inner nuclear membrane.

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New Professorship

Many congratulations to Folma Buss on her well-deserved promotion to Professor, reflecting both her research advances and her commitment to graduate education.

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2018 Academy of Medical Sciences Fellows

We are delighted that Jim Huntington has been elected as a Fellow of the Academy of Medical Sciences.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

 

 

 

 

 

New publications

 

Larrieu lab (Sci. Signalling 2018)

Transportin-1 targeted in progeria.

 

Siniossoglou lab (Dev. Cell 2018)

A conserved mechanism for membrane phospholipid sensing.

 

Larrieu lab (Nature Comm. 2018)

NAT10 inhibition increases healthspan of HGPS mice.

 

St George-Hyslop lab (Cell 2018)

Phase separation control of FUS in neurodegeneration.

 

Ron lab (J. Biol. Chem. 2018)

Inhibitor sensitivity of the eIF2a phosphatase revisited.

 

Marciniak lab (ASC Nano. 2018)

Measuring microviscosity dynamics inside organelles.

 

Rubinsztein lab (Dev. Cell 2018)

Recycling endosomes as a novel platform for autophagosome formation.

 

Ron and Warren labs (Science 2018)

CryoEM analysis of integrated stress response.

 

Nathan and Lehner labs (EMBO Rep. 2018)

Overlapping E3 ligase function in the ER.

 

Robinson lab (PLoS Biol. 2018)

AP-5 in endosome-to-Golgi transport.

 

Robinson lab (Nature Comm. 2018)

WDR11 in Golgi vesicle tethering.