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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Molecular sieving: a new rare disease mechanism

Molecular sieving: a new rare disease mechanism

New CIMR research led by Dr Joseph Chambers, PhD student Nikita Zubkov and Prof. Stefan Marciniak has revealed a new mechanism for certain types of rare genetic disease. Their new publication in...

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Read more at: The role of eIF6 in ribosome assembly and recycling

The role of eIF6 in ribosome assembly and recycling

Protein synthesis is a cyclical process in which ribosome components assemble to translate mRNA into protein, disassemble upon completion and are recycled back into further rounds of assembly. This...

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Read more at: Collaboration with the MRC Mitochondrial Biology Unit reveals a key step in mitochondrial ribosome assembly

Collaboration with the MRC Mitochondrial Biology Unit reveals a key step in mitochondrial ribosome assembly

A collaborative study between the groups of Drs Michal Minczuk, Alex Whitworth at the MBU and Alan Warren at the CIMR, published in Nature Communications, reports the identification of a critical...

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Read more at: Mitochondria set the pace of killing

Mitochondria set the pace of killing

Cytotoxic T lymphocytes (CTLs) recognise and destroy cells which are infected with viruses or are cancerous. This latter property puts them at the heart of new immunotherapies transforming cancer...

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Read more at: A structure-based understanding of how the Integrated Stress Response is switched off

A structure-based understanding of how the Integrated Stress Response is switched off

Like many key biological pathways, the Integrated Stress Response (ISR) is carefully regulated. A known molecular trigger for the ISR is the stress-induced phosphorylation of the α-subunit of...

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Latest news

Read more at: Inspiring Scientists at the Cambridge Institute for Medical Research (ISAC)

Inspiring Scientists at the Cambridge Institute for Medical Research (ISAC)

24 February 2022

Last week we were pleased to host our first ever ISAC programme in partnership with St Catharine’s College. Twelve students from Cambridgeshire 6th Form state schools took part in interactive...

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Read more at: A new home for some old equipment to inspire future researchers

A new home for some old equipment to inspire future researchers

7 February 2022

CIMR’s Head of Flow Cytometry, Dr Reiner Schulte recently visited Moulton School and Science College in Northampton to donate and demonstrate an old CIMR flow cytometer in the school lab. The...

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Read more at: Recognition for highly-cited CIMR researcher

Recognition for highly-cited CIMR researcher

18 November 2021

Professor David Rubinsztein FRS has been highlighted by Clarivate as a ‘Highly Cited Researcher’ in 2021. This is due to his highly-cited papers which rank in the top 1% by citations for field and...

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New CIMR publications

Marciniak lab (Science Advances, 2022)
Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state

Warren lab (Nature Communications, 2022)
eIF6 rebinding dynamically couples ribosome maturation and translation

Weekes lab (PNAS, 2022)
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Warren lab in collaboration with the Minczuk and Whitworth labs, MRC-MBU (Nature Communications, 2022)
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

Huntington lab (Blood, 2022)
Mapping the Prothrombin Binding Site of Pseutarin C by Site-directed PEGylation

Weekes lab (eLife, 2021)
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

Griffiths lab (Science, 2021)
Mitochondrial translation is required for sustained killing by cytotoxic T cells

Ron lab (Nature Structural & Molecular Biology, 2021)
Higher-order phosphatase–substrate contacts terminate the integrated stress response

Read lab (Proteins, 2021)
Assessing the utility of CASP14 models for molecular replacement

Warren lab in collaboration with the Revy lab, Paris (Nature Communications, 2021)
Somatic genetic rescue of a germline ribosome assembly defect

Ron lab (Nature Communications, 2021)
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

Griffiths lab (Journal of Cell Biology, 2021)
Signal strength controls the rate of polarization within CTLs during killing

Rayner lab (PLoS Pathogens, 2021)
Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

Rubinsztein lab (Developmental Cell, 2021)
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

Marciniak lab (European Respiratory Journal, 2021)
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant

Ron & Marciniak labs (Cell Reports, 2021)
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Luzio lab (Journal of Cell Science, 2021)
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway

 

 

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