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Cambridge Institute for Medical Research

Department A-Z

Our strategy

We aim to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

A Ron and Read lab collaboration in eLife has used biochemical and structural analyses to reveal the mechanism by which the ER chaperone BiP is inactivated through AMPylation.

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Research advances

In Cell Reports, Mike Weekes has collaborated with Georg Borner (MPI Biochemistry) to use dynamic organellar mapping to uncover the spatial proteome of >8,000 proteins in mouse primary neurons, demonstrating the application of this approach in specific cells and tissues.

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The future of medicine

A new video on technologies that could revolutionize medicine in the next 50 years, including Gillian Griffiths on the awakening of our immune system self-defence force.

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Lister Prize Fellow

Many congratulations to James Nathan, who has been awarded a Lister Research Prize Fellowship for his studies on the interplay between metabolism and oxygen-sensing enzymes.

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A unique partnership between basic and clinical research, aiming to understand the cellular basis of disease

 

 

 

 

 

New publications

 

Ron and Read labs (eLife 2017)

AMPylation inactivation switch for ER chaperone.

 

Robinson and Owen labs (JCB 2017)

Adaptor control of acidic cluster protein sorting.

 

Weekes lab (Cell Rep. 2017)

Dynamic organellar maps in primary neurons.

 

Lehner lab (Nature 2017)

Control of anti-tumour immunity.

 

Weekes lab (Cell Rep. 2017)

Temporal proteomics of EBV replication.

 

Read and Deane labs (Nature Comm. 2017)

Structural insights into Hunter syndrome.

 

Lehner lab (Nature Genetics 2017)

MORC2 in epigenetic silencing by HUSH complex.

 

Rubinsztein lab (Nature 2017)

PolyQ protein control of autophagy.