Plasmodium falciparum PfMyoF contains a Rab-like tail domain and associates with perinuclear membrane trafficking proteins
Members of the myosin superfamily are found in all eukaryotes, including Plasmodium falciparum, the parasite that causes the majority of severe malaria. They possess a limited and largely...
Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress
The endoplasmic reticulum (ER) is a central hub for protein folding and the maintenance of cellular homeostasis. When misfolded proteins accumulate in the ER, a cellular stress response known as the...
AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network
Machine learning has revolutionised structural biology, with tools like AlphaFold2 enabling rapid protein structure prediction from sequence alone. Yet challenges remain in modelling details such as...
A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells
Our bodies are constantly producing and secreting thousands of proteins, from antibodies that fight infection, to the structural proteins holding tissues together, to the signalling molecules that go...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilise their integrity. However, no specific cellular functions have yet been attributed to ribosome-bound polyamines despite...
The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes
Within eukaryotic cells, myosin motor proteins move cargo over short distances along actin tracks, regulate plasma membrane dynamics through the actin cortex and provide flexible tethering of...
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum
Eukaryotes are endowed with signaling pathways that couple the burden of protein folding in the lumen of their endoplasmic reticulum (ER) to rectifying changes in gene expression, mRNA translation...
Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1
Autophagy is a key proteostasis pathway that maintains cytoplasmic quality control by recycling damaged and/or superfluous cellular organelles and proteins, including many aggregation-prone proteins...
Melissa Gammons, Jeanne Salje, Holly Monkhouse and Ellie Fox recognised for their contributions to a more inclusive and supportive research community
2 June 2026
Many congratulations to CIMR group leaders Melissa Gammons and Jeanne Salje, and PhD students Holly Monkhouse and Ellie Fox for their nominations for the University of Cambridge Research Culture...
We were delighted to welcome a group of undergraduate students from Anglia Ruskin University's Biomedical Science Society yesterday (13th April). Three of our PhD students, Holly Monkhouse, Ellie Fox...
We had a great time on Saturday at the Cambridge Festival's Biomedical Campus Open Day. Well over 1,000 visitors enjoyed activities and demonstrations from many of the research institutions...
