Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
Hereditary spastic paraplegia (HSP) is a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Mutation of the ATL1 gene is one...
While both, vesicle-associated membrane protein 2 (VAMP2) and α -synuclein have been extensively studied, this study reveals a novel, unexpected role for their interaction. α-synuclein is a small...
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Protein phosphorylation activates important biological processes that are later deactivated by dephosphorylation. Phosphoserine/threonine dephosphorylation is catalyzed by holophosphatases comprising...
Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a disorder in which aberrant vascular remodelling raises pressures in the pulmonary vasculature, causing right heart failure. Affected young adults often...
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
A new paper from the Rubinsztein lab, led by Lidia Wrobel, describes how mutations in the AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), can contribute to diseases such as...
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle
Lysosomes function as the terminal degradative compartment of a cell’s endocytic and autophagic pathways, and as a multifunctional signalling hub integrating the cell’s response to nutrient status...
The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic
Adaptor protein (AP) complexes are an ancient family of heterotetramers, which select cargo for packaging into transport vesicles at various locations in the cell. The AP-1 adaptor is arguably the...
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
The pleural lining of the thorax regulates local immunity and wound healing. Disruption of these functions induces fibrosis and in the case of exposure to asbestos, chronic irritation can cause...
CIMR & MBU host students on the Aspiring Scientists Training Programme
12 July 2024
We have had a great week with a group of sixth-form students taking part in the Gurdon Institute's ASTP programme . As a widening participation scheme, the programme is targets young people who may...
We are delighted to announce that Janet Deane has just been promoted to Professor of Membrane Biology. This is a well-deserved recognition of the significant contribution she makes both at CIMR and...
We're delighted to announce that Janet Deane has been awarded the Inclusive Practise award at the Student-Led Teaching Awards (run by the Cambridge Students' Union). Nominated and selected by...
