Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane
Can a single viral protein change how you think? A collaborative study between the Deane Lab and the Graham Lab (Pathology) reveals how herpes simplex virus 1 (HSV-1) profoundly disrupts the function...
Cumulative Hematologic Morbidity and Outcomes in Shwachman–Diamond Syndrome
An international study of 865 people with Shwachman–Diamond syndrome (SDS) has provided the clearest picture to date of the long-term blood and cancer risks associated with this rare inherited...
Canonical lymphocyte chemokine receptors CXCR3 and CXCR5 modulate neuronal autophagy
Autophagy, a conserved cellular degradation process, plays a critical role in clearing toxic aggregate-prone proteins including α-synuclein in Parkinson’s disease, tau in Alzheimer’s disease and...
Dishevelled drives disassembly of primary cilia through an atypical PDZ domain–mediated binding mode with Girdin-
New research from the Gammons lab has identified Girdin-L as a key binding partner of Dishevelled, a central regulator of Wnt signalling. The study shows that Girdin-L binds directly to the PDZ...
G3BP1 depletion, observed in Parkinson's Disease, drives Golgi-lysosome-autophagy defects
The RNA binding G3BP1 is depleted in several neurodegenerative diseases, yet its functional consequences at the cellular level remain poorly understood, although it is best known for its critical...
Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex
The rixosome is a large protein complex found in mammalian cells that is essential for both ribosome production and the maintenance of tightly packed regions of DNA called heterochromatin. At its...
Dishevelled drives disassembly of primary cilia through an atypical PDZ domain–mediated binding mode with Girdin-
New research from the Gammons lab has identified Girdin-L as a key binding partner of Dishevelled, a central regulator of Wnt signalling. The study shows that Girdin-L binds directly to the PDZ...
Gene editing of alveolar organoids reveals AT2 dysfunction due to endosomal SFTPC accumulation
Alveolar type 2 (AT2) cell dysfunction is key to the development of many lung diseases including pulmonary fibrosis (PF). The underlying mechanisms often remain poorly understood due to a paucity of...
Michal Minczuk leads £7.7 million ARIA project to make mitochondria programmable
10 September 2026
Mitochondrial DNA has resisted the genetic engineering revolution for around 50 years. This week, Advanced Research + Invention Agency (ARIA) is launching an ambitious effort to change that...
Masters in the Molecular Mechanisms of Human Disease
10 September 2026
Applications are now open for the 2027-28 intake for the Masters in the Molecular Mechanisms of Human Disease. You can find more details on our course page
The CIMR Flow Cytometry Core Facility was delighted to host a second-year biomedical student from Anglia Ruskin University Peterborough for a one-week placement in August, offering an introduction to...
