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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Ectocytosis renders TCR signaling self-limiting at the immune synapse

Ectocytosis renders TCR signaling self-limiting at the immune synapse

Prof. Gillian Griffiths’s lab studies cytotoxic T lymphocytes (CTLs) - serial killers which destroy multiple targets in succession. A new Science paper from the lab describes a unique mechanism for...


Read more at: Boosting impaired autophagy in neurodegeneration

Boosting impaired autophagy in neurodegeneration

A new pathway of autophagy regulation has been identified from Prof. David Rubinsztein’s group at CIMR, which is also part of the UK Dementia Research Institute at Cambridge. Publishing in Neuron, Dr...


Read more at: A new molecular mechanism driving childhood neurodegenerative disease

A new molecular mechanism driving childhood neurodegenerative disease

Glycosphingolipids are an important class of lipids enriched in the outer leaflet of the plasma membrane. Disorders that alter glycosphingolipid metabolism cause devastating neurodegenerative and...


Read more at: Quantitative RUSH reveals exocyst is essential for mammalian cell secretion

Quantitative RUSH reveals exocyst is essential for mammalian cell secretion

The secretory pathway is a fundamental component of normal cellular function, but there is still much to discover about its precise mechanisms. CIMR’s Gershlick lab studies the dynamics and drivers...


Read more at: A molecular mechanism for a rare form of diabetes

A molecular mechanism for a rare form of diabetes

Rare cases of diabetes have been described in infants which can include other symptoms such as neurodevelopmental delay, and are monogenic in origin. A small but growing list of mutations identified...


Read more at: A new mechanism for substrate recruitment by receptor protein tyrosine phosphatases

A new mechanism for substrate recruitment by receptor protein tyrosine phosphatases

The labs of Dr Janet Deane at CIMR and Dr Hayley Sharpe at the Babraham Institute work collaboratively to understand the structures and substrate specificities of certain receptor protein tyrosine...


Latest news

Read more at: CIMR’s Annual Research Retreat

CIMR’s Annual Research Retreat

18 May 2023

Our annual Research Retreat at the Hinxton Hall Conference Centre was a success, with a mix of 15 min presentations, Institute updates, and short ‘turbo talks’ to highlight some of the 34 posters...


Read more at: Prof. Julian Rayner elected Fellow of the Academy of Medical Sciences

Prof. Julian Rayner elected Fellow of the Academy of Medical Sciences

17 May 2023

CIMR’s Director, Prof. Julian Rayner has been elected as a Fellow of the Academy of Medical Sciences. This prestigious honour is in recognition of Prof. Rayner’s ongoing contributions and leadership...


Read more at: Teaching protein biochemistry in Brazil

Teaching protein biochemistry in Brazil

17 April 2023

Dr Janet Deane and Professor Stephen Graham travelled to Brazil in March to teach a theoretical and practical course in Protein Biochemistry, Biophysics and Structural Biology. The course was held at...


New CIMR publications

Griffiths lab (Science, 2023)
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse

Rubinsztein lab (Neuron, 2023)
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Deane lab (PNAS, 2023)
Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

Warren lab (Nucleic Acid Res., 2023)
Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution

Gershlick lab (J. Cell Biology, 2023)
The exocyst complex is an essential component of the mammalian constitutive secretory pathway

Read lab (Acta Crystallographica Section D, 2023)
Likelihood-based docking of models into cryo-EM maps

Ron lab in collaboration with Elisa De Franco and Andrew Hattersley [University of Exeter] (EMBO Mol. Med 2023)
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP

Read group in collaboration with Tom Terwilliger [Los Alamos National Laboratory] and other members of the Phenix collaboration (Acta Crystallographica Section D, 2022)
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE

Deane lab in collaboration with the Sharpe lab, Babraham (eLife, 2022)
Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

Warren lab in collaboration with the Bergler lab [Graz] and Haselbach lab [Vienna] (Nature Structural & Molecular Biology 2022)
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

Larrieu lab (Nucleic Acids Research, 2022)
BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor–Guillermo progeria syndrome cells

Rubinsztein lab (Nature Communications, 2022)
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Marciniak lab (Science Advances, 2022)
Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state

Warren lab (Nature Communications, 2022)
eIF6 rebinding dynamically couples ribosome maturation and translation

Weekes lab (PNAS, 2022)
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Warren lab in collaboration with the Minczuk and Whitworth labs, MRC-MBU (Nature Communications, 2022)
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

Huntington lab (Blood, 2022)
Mapping the Prothrombin Binding Site of Pseutarin C by Site-directed PEGylation

 

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