PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
The rixosome is a large multisubunit complex that initiates RNA decay during critical nuclear transactions including ribosome assembly and heterochromatin maintenance. The overall architecture of the...
The intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility
The intracellular bacterium Orientia tsutsugamushi relies on the microtubule cytoskeleton and the motor protein dynein to traffic to the perinuclear region within infected cells. However, it remains...
Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction
Glycosphingolipids (GSL) are important bioactive membrane components. GSLs containing sialic acids, known as gangliosides, are highly abundant in the brain and diseases of ganglioside metabolism...
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis
Glycosphingolipids (GSLs) are crucial membrane components involved in essential cellular pathways. Complex GSLs, known as gangliosides, are synthesised by glycosyltransferase enzymes, and imbalances...
Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease
Scrub typhus is a vector-borne human disease caused by the bacterium Orientia tsutsugmushi and spread by mites. There are numerous different strains of this bacterium with some causing severe disease...
Transferrin Receptor controls both autophagosome formation and closure via Phosphatidylinositol 3-phosphate synthesis
Macroautophagy (henceforth autophagy) is an evolutionary conserved mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic proteins and organelles...
Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
The Wnt signalling cascade is an ancient cell communication system that operates in all animals and humans to control embryonic development and stem cells in adult tissues. If dysregulated, it is...
Alpha-synuclein mutations mislocalise cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterised by motor dysfunction, neuronal loss in different regions of the brain, and the accumulation of α-...
Now in its third year, we once again ran the on-line event Reaching Research at the end of July. Organised by two of our PhD students, Ellie Fox and Holly Monkhouse, this accessible widening...
We had a great week last week with a group of year 12 students attending the Gurdon Institute's ASTP programme . This is a fantastic work experience and widening participation programme which gives...
CIMR appoints Dr Jennifer Dickens as a Prinicipal Investigator
27 May 2025
CIMR is delighted to announce the appointment of a new PI, Dr Jennifer Dickens. Jenny is an active clinician, balancing her research work on the molecular mechanisms of pulmonary fibrosis with...
