Ectocytosis renders TCR signaling self-limiting at the immune synapse
Prof. Gillian Griffiths’s lab studies cytotoxic T lymphocytes (CTLs) - serial killers which destroy multiple targets in succession. A new Science paper from the lab describes a unique mechanism for...
A new pathway of autophagy regulation has been identified from Prof. David Rubinsztein’s group at CIMR, which is also part of the UK Dementia Research Institute at Cambridge. Publishing in Neuron, Dr...
A new molecular mechanism driving childhood neurodegenerative disease
Glycosphingolipids are an important class of lipids enriched in the outer leaflet of the plasma membrane. Disorders that alter glycosphingolipid metabolism cause devastating neurodegenerative and...
Quantitative RUSH reveals exocyst is essential for mammalian cell secretion
The secretory pathway is a fundamental component of normal cellular function, but there is still much to discover about its precise mechanisms. CIMR’s Gershlick lab studies the dynamics and drivers...
Rare cases of diabetes have been described in infants which can include other symptoms such as neurodevelopmental delay, and are monogenic in origin. A small but growing list of mutations identified...
A new mechanism for substrate recruitment by receptor protein tyrosine phosphatases
The labs of Dr Janet Deane at CIMR and Dr Hayley Sharpe at the Babraham Institute work collaboratively to understand the structures and substrate specificities of certain receptor protein tyrosine...
Our annual Research Retreat at the Hinxton Hall Conference Centre was a success, with a mix of 15 min presentations, Institute updates, and short ‘turbo talks’ to highlight some of the 34 posters...
Prof. Julian Rayner elected Fellow of the Academy of Medical Sciences
17 May 2023
CIMR’s Director, Prof. Julian Rayner has been elected as a Fellow of the Academy of Medical Sciences. This prestigious honour is in recognition of Prof. Rayner’s ongoing contributions and leadership...
Dr Janet Deane and Professor Stephen Graham travelled to Brazil in March to teach a theoretical and practical course in Protein Biochemistry, Biophysics and Structural Biology. The course was held at...
