The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes
Within eukaryotic cells, myosin motor proteins move cargo over short distances along actin tracks, regulate plasma membrane dynamics through the actin cortex and provide flexible tethering of...
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum
Eukaryotes are endowed with signaling pathways that couple the burden of protein folding in the lumen of their endoplasmic reticulum (ER) to rectifying changes in gene expression, mRNA translation...
Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1
Autophagy is a key proteostasis pathway that maintains cytoplasmic quality control by recycling damaged and/or superfluous cellular organelles and proteins, including many aggregation-prone proteins...
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
The rixosome is a large multisubunit complex that initiates RNA decay during critical nuclear transactions including ribosome assembly and heterochromatin maintenance. The overall architecture of the...
The intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility
The intracellular bacterium Orientia tsutsugamushi relies on the microtubule cytoskeleton and the motor protein dynein to traffic to the perinuclear region within infected cells. However, it remains...
Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction
Glycosphingolipids (GSL) are important bioactive membrane components. GSLs containing sialic acids, known as gangliosides, are highly abundant in the brain and diseases of ganglioside metabolism...
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis
Glycosphingolipids (GSLs) are crucial membrane components involved in essential cellular pathways. Complex GSLs, known as gangliosides, are synthesised by glycosyltransferase enzymes, and imbalances...
Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease
Scrub typhus is a vector-borne human disease caused by the bacterium Orientia tsutsugmushi and spread by mites. There are numerous different strains of this bacterium with some causing severe disease...
New 3D microscopy technique allows researchers to visualise individual molecules inside living cells
20 January 2026
A collaboration between Dr Sam Daly (David Gershlick’s lab) and Prof Lee’s lab in the Yusuf Hamied Department of Chemistry has made it possible to track in three dimensions individual molecules as...
PhD student Eleanor Fox wins EMBO Journal Poster Prize
18 December 2025
Many congratulations to PhD student Eleanor Fox who has been awarded the EMBO Journal Poster Prize, at the UK Membrane Trafficking Meeting 2025 held in King’s College London. Eleanor, who is a PhD...
Jennifer Palmer wins UK Dementia Research Institute PhD prize
11 December 2025
Many congratulations to PhD student Jennifer Palmer who has been awarded the UK Dementia Research Institute PhD prize. This award aims to recognise and celebrate the outstanding achievements of...
