Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Appropriate cellular recognition of viruses is essential for the generation of an effective innate and adaptive immune response. Viral sensors and their downstream signaling components thus provide a...
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
Malaria parasites are highly divergent from model eukaryotes. Large-scale genome engineering methods effective in model organisms are frequently inapplicable, and systematic studies of gene function...
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD)...
Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion
Biogenesis of membrane-bound organelles involves the synthesis, remodeling, and degradation of their constituent phospholipids. How these pathways regulate organelle size remains poorly understood...
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Tauopathies are neurodegenerative diseases which show intracellular accumulation and aggregation of tau protein. In diseases such as Pick's disease, progressive supranuclear palsy, corticobasal...
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
The endoplasmic reticulum (ER) constitutes the major cellular compartment for the synthesis, folding, and quality control of secretory proteins. An imbalance between synthesis and folding can lead to...
Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise
Autophagy is a pathway conserved from yeast to humans enabling the degradation of cytoplasmic proteins and organelles. After such substrates are captured by autophagosomes, these are trafficked to...
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
Hereditary spastic paraplegia (HSP) is a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Mutation of the ATL1 gene is one...
Inspiring Scientists at CIMR-MBU 2025 - Applications open!
21 October 2024
We're excited to launch this year's ISAC-M programme in collaboration with the MRC Mitochondrial Biology Unit. This widening participation/ work experience programme is a great way for young people...
CIMR is delighted to welcome our new graduate students this term. As well as PHD and MPhil students we have our first cohort studying for our new Masters course, Molecular Mechanisms of Human Disease...
Members of the Deane lab have taken outreach to new heights - or should that be distances! – by joining in with a school science week in Australia. The team made a fun video for the children at St...
