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Cambridge Institute for Medical Research

Department A-Z

Our strategy

CIMR is a unique partnership between basic and clinical research, aiming to understand the cellular basis of disease. Our goal is to create an inspiring environment in which outstanding scientists can excel. By providing state-of-the-art core facilities and support for our researchers, we foster new collaborations that spark discoveries about fundamental cellular processes and their relevance in disease.

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Research advances

In Nature Communications, Alexandra Davies in the Robinson lab has uncovered a novel role for the adaptor protein AP-4 in regulating the cellular recycling process autophagy.

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Research advances

Writing in Nature Cell Biology, Edward Avezov (Ron Lab and UK DRI), Joe Chambers (Marciniak Lab) and their collaborators at the Department of Chemical Engineering of Cambridge University and the École Normale Supérieure of Paris report on an active process that distributes the contents of the endoplasmic reticulum throughout mammalian cells

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Research advances

Chris Gawden-Bone in the Griffiths lab has revealed in Immunity that PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

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Research Advances

Sung Min Son in the Rubinsztein group has reported in Cell Metabolism that in some cells, mTOR complex 1 can be activated by leucine via its metabolite acetyl-CoA.

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Research advances

The Rubinsztein group report in Nature Communications that inhibition of cellular recycling through autophagy is an important consequence of contact inhibition.

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Research advances

Arianne Richard in the Griffiths (CIMR) and Marioni (CRUK Cambridge institute) labs has reported in Nature Immunology that the killing capacity of cytotoxic T cells is independent of initial ligand stimulation strength.

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Research advances

The Larrieu (CIMR) and Jackson groups (Gurdon Institute) reveal in Science Signalling that the transportin-1 nuclear import pathway is an essential target of NAT10 acetyltransferase in progeria and ageing.

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Research advances

In Cell Host and Microbe, the Weekes lab have taken a multiplexed proteomics approach to determine which of >10,000 host proteins are degraded during infection by human cytomegalovirus (HCMV), and identify a DNA helicase as a novel anti-viral restriction factor.

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Wellcome Trust PhD for Clinicians Programme—Applications for 2019 intake now open

Closing date for applications is Thursday 15th November 2018.

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New Professorship

Many congratulations to Folma Buss on her well-deserved promotion to Professor, reflecting both her research advances and her commitment to graduate education.

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2018 Academy of Medical Sciences Fellows

We are delighted that Jim Huntington has been elected as a Fellow of the Academy of Medical Sciences.

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Postgraduate Open Day

New publications

Robinson lab (Nature Comm. 2018)

AP-4 adaptor in autophagy

 

Ron lab (Nature Cell Biology)

Single particle trajectories reveal active endoplasmic reticulum luminal flow

Griffiths Lab (Immunity)

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

 

Rubinsztein lab (Cell Metabolism)

Leucine metabolism regulates mTORC1

 

Weekes lab (Cell Host Microbe 2018)

Global analysis of antiviral factors degraded by HCMV

Rubinsztein lab (Nature Comm. 2018)

Autophagy control in contact inhibition.

 

Griffiths lab (Nature Immunol. 2018)

Single cell insights into T cell killing capacity.

 

Larrieu lab (Sci. Signalling 2018)

Transportin-1 targeted in progeria.

 

Siniossoglou lab (Dev. Cell 2018)

A conserved mechanism for membrane phospholipid sensing.

 

Larrieu lab (Nature Comm. 2018)

NAT10 inhibition increases healthspan of HGPS mice.

 

St George-Hyslop lab (Cell 2018)

Phase separation control of FUS in neurodegeneration.

 

Ron lab (J. Biol. Chem. 2018)

Inhibitor sensitivity of the eIF2a phosphatase revisited.

 

Marciniak lab (ASC Nano. 2018)

Measuring microviscosity dynamics inside organelles.

 

Rubinsztein lab (Dev. Cell 2018)

Recycling endosomes as a novel platform for autophagosome formation.

 

Ron and Warren labs (Science 2018)

CryoEM analysis of integrated stress response.

 

Nathan and Lehner labs (EMBO Rep. 2018)

Overlapping E3 ligase function in the ER.