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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Cytotoxic T cell activation and signal strength

Cytotoxic T cell activation and signal strength

Cytotoxic T lymphocytes (CTLs) of the immune system combat virally infected and cancerous cells. Killing is finely controlled according to the strength of signal generated upon T cell receptor (TCR)...

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Read more at: New vaccine targets for a neglected malaria parasite

New vaccine targets for a neglected malaria parasite

The development of effective vaccines against the Plasmodium parasites which cause malaria is a major, global research goal. There has been recent progress against P.falciparum , but another species...

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Read more at: A new phosphorylation pathway to autophagy

A new phosphorylation pathway to autophagy

Glucose starvation can activate cellular autophagy, but the exact mechanisms of this have been unclear. PhD student Cansu Karabiyik and colleagues from the Rubinsztein lab have recently uncovered a...

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Read more at: Molecular mechanisms of a rare lung disease

Molecular mechanisms of a rare lung disease

Pulmonary fibrosis (lung scarring) is a serious feature of many different lung diseases, but its precise causes are not well understood. Dr Jennifer Dickens and colleagues from Prof. Stefan Marciniak...

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Read more at: New molecular insights into alpha-1-antitrypsin-deficiency

New molecular insights into alpha-1-antitrypsin-deficiency

Alpha-1-antitrypsin (α1AT) deficiency is a rare genetic disease which can cause chronic obstructive pulmonary disease and liver cirrhosis. This condition is understood to arise from the intracellular...

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Latest news

Read more at: CIMR involvement in a new widening participation initiative for students

CIMR involvement in a new widening participation initiative for students

16 July 2021

Experience Postgrad Life Sciences is a residential summer internship programme at Cambridge for undergraduate students of biological / biomedical science subjects who may not otherwise be able to...

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Read more at: A new rare disease network

A new rare disease network

30 June 2021

Professor Stefan Marciniak is a research group leader at CIMR and an honorary consultant respiratory physician at both Cambridge University Hospitals NHS Foundation Trust and Royal Papworth. He will...

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Read more at: CIMR researcher to lead a new research consortium tackling chronic pain

CIMR researcher to lead a new research consortium tackling chronic pain

1 June 2021

Four multidisciplinary research consortia have recently been funded by UKRI, Versus Arthritis and Eli Lily to investigate chronic pain. The ADVANTAGE Consortium is led by CIMR’s Prof. Geoff Woods and...

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New CIMR publications

Griffiths lab (Journal of Cell Biology, 2021)
Signal strength controls the rate of polarization within CTLs during killing

Rayner lab (PLoS Pathogens, 2021)
Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

Rubinsztein lab (Developmental Cell, 2021)
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

Marciniak lab (European Respiratory Journal, 2021)
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant

Ron & Marciniak labs (Cell Reports, 2021)
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Luzio lab (Journal of Cell Science, 2021)
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway

Rubinsztein lab
(Nature Communications, 2021)
α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

(Nature Chemical Biology, 2021)
VCP/p97 regulates Beclin-1-dependent autophagy initiation 

Weekes lab (Frontiers in Cellular and Infectious Microbiology, 2021)
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics

Robinson lab (Journal of Cell Biology, 2021)
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex

Rubinsztein lab (Cell Reports, 2020)
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR

Ron lab (eLife, 2020)
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

Ron lab in collaboration with the Ito lab, RIKEN (Molecular Cell, 2020)
ISRIB blunts the Integrated Stress Response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

Raymond and Reid labs (American Journal of Human Genetics, 2020)
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment

Rayner lab (Nature, 2020)
Red blood cell tension protects against severe malaria in the Dantu blood group

 

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