A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
The endoplasmic reticulum (ER) constitutes the major cellular compartment for the synthesis, folding, and quality control of secretory proteins. An imbalance between synthesis and folding can lead to...
Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise
Autophagy is a pathway conserved from yeast to humans enabling the degradation of cytoplasmic proteins and organelles. After such substrates are captured by autophagosomes, these are trafficked to...
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
Hereditary spastic paraplegia (HSP) is a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Mutation of the ATL1 gene is one...
While both, vesicle-associated membrane protein 2 (VAMP2) and α -synuclein have been extensively studied, this study reveals a novel, unexpected role for their interaction. α-synuclein is a small...
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Protein phosphorylation activates important biological processes that are later deactivated by dephosphorylation. Phosphoserine/threonine dephosphorylation is catalyzed by holophosphatases comprising...
Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a disorder in which aberrant vascular remodelling raises pressures in the pulmonary vasculature, causing right heart failure. Affected young adults often...
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
A new paper from the Rubinsztein lab, led by Lidia Wrobel, describes how mutations in the AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), can contribute to diseases such as...
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle
Lysosomes function as the terminal degradative compartment of a cell’s endocytic and autophagic pathways, and as a multifunctional signalling hub integrating the cell’s response to nutrient status...
Members of the Deane lab have taken outreach to new heights - or should that be distances! – by joining in with a school science week in Australia. The team made a fun video for the children at St...
Last week CIMR hosted an on-line event, held over three mornings, for sixth form students looking to pursue careers in medicine or biomedical sciences. Students heard talks from scientists at all...
CIMR & MBU host students on the Aspiring Scientists Training Programme
12 July 2024
We have had a great week with a group of sixth-form students taking part in the Gurdon Institute's ASTP programme . As a widening participation scheme, the programme is targets young people who may...
