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Cambridge Institute for Medical Research

CIMR’s mission is to determine the molecular mechanisms of disease in order to advance human health.

 

CIMR Research Advances

Read more at: Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion

Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion

Tauopathies are neurodegenerative diseases which show intracellular accumulation and aggregation of tau protein. In diseases such as Pick's disease, progressive supranuclear palsy, corticobasal...


Read more at: A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

The endoplasmic reticulum (ER) constitutes the major cellular compartment for the synthesis, folding, and quality control of secretory proteins. An imbalance between synthesis and folding can lead to...


Read more at: Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise

Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise

Autophagy is a pathway conserved from yeast to humans enabling the degradation of cytoplasmic proteins and organelles. After such substrates are captured by autophagosomes, these are trafficked to...


Read more at: Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

Hereditary spastic paraplegia (HSP) is a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Mutation of the ATL1 gene is one...


Read more at: VAMP2 regulates phase separation of α-synuclein

VAMP2 regulates phase separation of α-synuclein

While both, vesicle-associated membrane protein 2 (VAMP2) and α -synuclein have been extensively studied, this study reveals a novel, unexpected role for their interaction. α-synuclein is a small...


Read more at: Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response

Protein phosphorylation activates important biological processes that are later deactivated by dephosphorylation. Phosphoserine/threonine dephosphorylation is catalyzed by holophosphatases comprising...


Read more at: Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a disorder in which aberrant vascular remodelling raises pressures in the pulmonary vasculature, causing right heart failure. Affected young adults often...


Read more at: p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

A new paper from the Rubinsztein lab, led by Lidia Wrobel, describes how mutations in the AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), can contribute to diseases such as...


Latest news

Read more at: Inspiring Scientists at CIMR-MBU 2025 - Applications open!

Inspiring Scientists at CIMR-MBU 2025 - Applications open!

21 October 2024

We're excited to launch this year's ISAC-M programme in collaboration with the MRC Mitochondrial Biology Unit. This widening participation/ work experience programme is a great way for young people...


Read more at: Welcome to our new students!

Welcome to our new students!

21 October 2024

CIMR is delighted to welcome our new graduate students this term. As well as PHD and MPhil students we have our first cohort studying for our new Masters course, Molecular Mechanisms of Human Disease...


Read more at: Outback Outreach!

Outback Outreach!

19 August 2024

Members of the Deane lab have taken outreach to new heights - or should that be distances! – by joining in with a school science week in Australia. The team made a fun video for the children at St...


New CIMR publications

Rubinsztein lan (Nature Chemical Biology 2024)

Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion.

Buss lab (Nature Communications 2024)

Motor domain phosphorylation increases nucleotide exchange and turns MYO6 into a faster and stronger motor.

Ron lab (eLife 2024)

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

Rubinsztein lab (Nature Cell Biology 2024)

Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise

Reid lab (Neurobiology of Disease 2024)

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

Lautenschlager lab (Nature Cell Biology 2024)

VAMP2 regulates phase separation of α-synuclein

VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates

Ron lab (PNAS 2024)

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response

Marciniak lab (Human Molecular Genetics 2024)

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension | Human Molecular Genetics | Oxford Academic (oup.com) 

Reiner Schulte (contributor, Springer Protocols 2024) 

Practicalities of Cell Sorting

Rubinsztein lab (Science Advances 2024)

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

Luzio lab (Molecular Biology of the Cell 2024)

Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

Robinson lab (Journal of Cell Biology 2024)

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

Marciniak lab, in collaboration with Prof Rintoul (Royal Papworth Hospital) & Matthew Garnett (Sanger Institute) (European Respiratory Journal 2024)

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

Weekes lab (Cell Host & Microbe 2024)

Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly

Rubinsztein lab (Nature Cell Biology 2024)

Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis 

Rubinsztein lab (Nature Cell Biology 2024)

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome

Ron lab (The EMBO Journal, 2023)
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Weekes lab (Nature Communications, 2023)
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Salje lab (mSphere, 2023)
Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium | mSphere (asm.org) 

Woods lab (Journal of Medical Genetics, 2023)
Evidence of a genetic background predisposing to complex regional pain syndrome type 1

Rayner/ Deane labs (Nature Communications, 2023)
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Rubinsztein lab (Developmental Cell, 2023)
Mammalian autophagosomes form from finger-like phagophores

Warren lab in a collaboration co-led with the Nangalia lab [Wellcome Sanger Institute; Cambridge Stem Cell Institute] and Kent lab [University of York] (Nature Communications, 2023)
Convergent somatic evolution commences in utero in a germline ribosomopathy 

Weekes lab (Cell Reports, 2023)
Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity

Weekes lab in collaboration with Gewurz lab [Harvard Medical School] (Molecular Cell, 2023)
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

Griffiths lab (Science, 2023)
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse

Rubinsztein lab (Neuron, 2023)
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Deane lab (PNAS, 2023)
Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

Warren lab (Nucleic Acid Res., 2023)
Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution

Gershlick lab (J. Cell Biology, 2023)
The exocyst complex is an essential component of the mammalian constitutive secretory pathway

Read lab (Acta Crystallographica Section D, 2023)
Likelihood-based docking of models into cryo-EM maps

Ron lab in collaboration with Elisa De Franco and Andrew Hattersley [University of Exeter] (EMBO Mol. Med 2023)
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP

 

 

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