2023
Warren lab (Nucleic Acid Res., 2023)
Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution
Gershlick lab (J. Cell Biology, 2023)
The exocyst complex is an essential component of the mammalian constitutive secretory pathway
Read lab (Acta Crystallographica Section D, 2023)
Likelihood-based docking of models into cryo-EM maps
Ron lab in collaboration with Elisa De Franco and Andrew Hattersley [University of Exeter] (EMBO Mol. Med 2023)
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP
2022
Read group in collaboration with Tom Terwilliger (Los Alamos National Laboratory) and other members of the Phenix collaboration (Acta Crystallographica Section D, 2022)
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE
Deane lab in collaboration with the Sharpe lab, Babraham (eLife, 2022)
Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain
Warren lab in collaboration with the Bergler lab [Graz] and Haselbach lab [Vienna] (Nature Structural & Molecular Biology 2022)
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1
Larrieu lab (Nucleic Acids Research, 2022)
BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor–Guillermo progeria syndrome cells
Rubinsztein lab (Nature Communications, 2022)
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Marciniak lab (Science Advances, 2022)
Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state
Warren lab (Nature Communications, 2022)
eIF6 rebinding dynamically couples ribosome maturation and translation
Weekes lab (PNAS, 2022)
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Warren lab in collaboration with the Minczuk and Whitworth labs, MRC-MBU (Nature Communications, 2022)
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
Huntington lab (Blood, 2022)
Mapping the Prothrombin Binding Site of Pseutarin C by Site-directed PEGylation
2021
Deane lab (Contact, 2021)
A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins
Weekes lab (eLife, 2021)
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers
Griffiths lab (Science, 2021)
Mitochondrial translation is required for sustained killing by cytotoxic T cells
Ron lab (Nature Structural & Molecular Biology, 2021)
Higher-order phosphatase–substrate contacts terminate the integrated stress response
Read lab (Proteins, 2021)
Assessing the utility of CASP14 models for molecular replacement
Warren lab in collaboration with the Revy lab, Paris (Nature Communications, 2021)
Somatic genetic rescue of a germline ribosome assembly defect
Ron lab (Nature Communications, 2021)
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD
Griffiths lab (Journal of Cell Biology, 2021)
Signal strength controls the rate of polarization within CTLs during killing
Rayner lab (PLoS Pathogens, 2021)
Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates
Rubinsztein lab (Developmental Cell, 2021)
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
Marciniak lab (European Respiratory Journal, 2021)
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant
Ron & Marciniak labs (Cell Reports, 2021)
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Luzio lab (Journal of Cell Science, 2021)
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway
Rubinsztein lab:
(Nature Communications, 2021)
α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
(Nature Chemical Biology, 2021)
VCP/p97 regulates Beclin-1-dependent autophagy initiation
Weekes lab (Frontiers in Cellular and Infectious Microbiology, 2021)
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics
Robinson lab (Journal of Cell Biology, 2021)
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex
2020
Rubinsztein lab (Cell Reports, 2020)
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR
Ron lab (eLife, 2020)
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
Ron lab in collaboration with the Ito lab, RIKEN (Molecular Cell, 2020)
ISRIB blunts the Integrated Stress Response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B
Raymond and Reid labs (American Journal of Human Genetics, 2020)
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment
Rayner lab (Nature, 2020)
Red blood cell tension protects against severe malaria in the Dantu blood group
Maxwell lab (Nature Immunology, 2020)
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development
Weekes lab (PNAS, 2020)
Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor
Woods lab (Cell Reports, 2020)
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit
Deane lab (Nature Communications, 2020)
The receptor PTPRU is a redox sensitive pseudophosphatase
Rubinsztein lab (Nature Communications, 2020)
Leucine regulates autophagy via acetylation of the mTORC1 component raptor
Rubinsztein lab in collaboration with the Goldberg lab, Harvard (PNAS, 2020)
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
Griffiths lab (eLife, 2020)
Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling
Buss lab (Journal of Cell Science, 2020)
OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion
Rubinsztein lab (Developmental Cell, 2020)
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy
Buss lab (Biology of Reproduction, 2020)
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis
Weekes lab (Scientific Reports, 2020)
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes
Buss lab (Traffic, 2020)
Ultrastructural insights into pathogen clearance by autophagy
Read lab (Acta Crystallographica Section D, 2020)
Measuring and Using Information Gained by Observing Diffraction Data
Read lab (Acta Crystallographica Section D, 2020)
Factors influencing estimates of coordinate error for molecular replacement
2019
Ron lab (eLife, 2019)
Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR
Weekes lab (eLife, 2019)
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Rubinsztein lab (eLife, 2019)
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy
Ron lab (eLife, 2019)
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells
Griffiths lab (Journal of Clinical Investigation, 2019)
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
Reid lab (Frontiers in Neuroscience, 2019)
Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function
Deane lab (Wellcome Open Research, 2019)
The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading
Reid lab (Cellular and Molecular Life Sciences, 2019)
ESCRT‑III‑associated proteins and spastin inhibit protrudin‑dependent polarised membrane traffic
Ron lab (EMBO Journal, 2019)
An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP
Robinson lab (Traffic, 2019)
Fast and cloning‐free CRISPR/Cas9‐mediated genomic editing in mammalian cells
Weekes lab (Communications Biology, 2019)
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations
St George-Hyslop lab (Cell, 2019)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Siniossoglou lab (Developmental Cell, 2019)
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization
Weekes lab (Cell Metabolism, 2019)
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation
Warren lab (Blood, 2019)
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.
Warren lab (eLife, 2019)
Mechanism of completion of peptidyltransferase centre assembly in eukaryotes
Weekes lab (Cell Reports, 2019)
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist
Rubinsztein lab (Nature Communications, 2019)
Felodipine ameliorates neurodegeneration in mice
Sharpe lab (eLife, 2019)
The receptor PTPRK selectively dephosphorylates junctional regulators
Ron lab (Nature Comm, 2019)
MANF anatagonizes nucleotide exchange by the enodplasmic reticulum chaperone BiP