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Cambridge Institute for Medical Research



Ron lab (The EMBO Journal, 2023)
The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

Weekes lab (Nature Communications, 2023)
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection

Salje lab (mSphere, 2023)
Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium | mSphere (

Woods lab (Journal of Medical Genetics, 2023)
Evidence of a genetic background predisposing to complex regional pain syndrome type 1

Rayner/ Deane labs (Nature Communications, 2023)
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.

Rubinsztein lab (Developmental Cell, 2023)
Mammalian autophagosomes form from finger-like phagophores

Warren lab in a collaboration co-led with the Nangalia lab [Wellcome Sanger Institute; Cambridge Stem Cell Institute] and Kent lab [University of York] (Nature Communications, 2023)
Convergent somatic evolution commences in utero in a germline ribosomopathy 

Weekes lab (Cell Reports, 2023)
Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity

Weekes lab in collaboration with Gewurz lab [Harvard Medical School] (Molecular Cell, 2023)
An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

Griffiths lab (Science, 2023)
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse

Rubinsztein lab (Neuron, 2023)
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Deane lab (PNAS, 2023)
Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

Warren lab (Nucleic Acid Res., 2023)
Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution

Gershlick lab (J. Cell Biology, 2023)
The exocyst complex is an essential component of the mammalian constitutive secretory pathway

Read lab (Acta Crystallographica Section D, 2023)
Likelihood-based docking of models into cryo-EM maps

Ron lab in collaboration with Elisa De Franco and Andrew Hattersley [University of Exeter] (EMBO Mol. Med 2023)
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP


Read group in collaboration with Tom Terwilliger (Los Alamos National Laboratory) and other members of the Phenix collaboration (Acta Crystallographica Section D, 2022)
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE

Deane lab in collaboration with the Sharpe lab, Babraham (eLife, 2022)
Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

Warren lab in collaboration with the Bergler lab [Graz] and Haselbach lab [Vienna] (Nature Structural & Molecular Biology 2022)
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

Larrieu lab (Nucleic Acids Research, 2022)
BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor–Guillermo progeria syndrome cells

Rubinsztein lab (Nature Communications, 2022)
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Marciniak lab (Science Advances, 2022)
Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state

Warren lab (Nature Communications, 2022)
eIF6 rebinding dynamically couples ribosome maturation and translation

Weekes lab (PNAS, 2022)
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Warren lab in collaboration with the Minczuk and Whitworth labs, MRC-MBU (Nature Communications, 2022)
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

Huntington lab (Blood, 2022)
Mapping the Prothrombin Binding Site of Pseutarin C by Site-directed PEGylation