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Cambridge Institute for Medical Research

 

2022

Read group in collaboration with Tom Terwilliger (Los Alamos National Laboratory) and other members of the Phenix collaboration (Acta Crystallographica Section D, 2022)
Putting AlphaFold models to work with phenix.process_predicted_model and ISOLDE

Deane lab in collaboration with the Sharpe lab, Babraham (eLife, 2022)
Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

Warren lab in collaboration with the Bergler lab [Graz] and Haselbach lab [Vienna] (Nature Structural & Molecular Biology 2022)
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

Larrieu lab (Nucleic Acids Research, 2022)
BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor–Guillermo progeria syndrome cells

Rubinsztein lab (Nature Communications, 2022)
Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

Marciniak lab (Science Advances, 2022)
Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state

Warren lab (Nature Communications, 2022)
eIF6 rebinding dynamically couples ribosome maturation and translation

Weekes lab (PNAS, 2022)
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

Warren lab in collaboration with the Minczuk and Whitworth labs, MRC-MBU (Nature Communications, 2022)
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit

Huntington lab (Blood, 2022)
Mapping the Prothrombin Binding Site of Pseutarin C by Site-directed PEGylation

2021

Deane lab (Contact, 2021)
A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins

Weekes lab (eLife, 2021)
Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

Griffiths lab (Science, 2021)
Mitochondrial translation is required for sustained killing by cytotoxic T cells

Ron lab (Nature Structural & Molecular Biology, 2021)
Higher-order phosphatase–substrate contacts terminate the integrated stress response

Read lab (Proteins, 2021)
Assessing the utility of CASP14 models for molecular replacement

Warren lab in collaboration with the Revy lab, Paris (Nature Communications, 2021)
Somatic genetic rescue of a germline ribosome assembly defect

Ron lab (Nature Communications, 2021)
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

Griffiths lab (Journal of Cell Biology, 2021)
Signal strength controls the rate of polarization within CTLs during killing

Rayner lab (PLoS Pathogens, 2021)
Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

Rubinsztein lab (Developmental Cell, 2021)
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

Marciniak lab (European Respiratory Journal, 2021)
Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant

Ron & Marciniak labs (Cell Reports, 2021)
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

Luzio lab (Journal of Cell Science, 2021)
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway

Rubinsztein lab:
(Nature Communications, 2021)
α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

(Nature Chemical Biology, 2021)
VCP/p97 regulates Beclin-1-dependent autophagy initiation 

Weekes lab (Frontiers in Cellular and Infectious Microbiology, 2021)
Rapid Degradation Pathways of Host Proteins During HCMV Infection Revealed by Quantitative Proteomics

Robinson lab (Journal of Cell Biology, 2021)
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex

2020

Rubinsztein lab (Cell Reports, 2020)
mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR

Ron lab (eLife, 2020)
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

Ron lab in collaboration with the Ito lab, RIKEN (Molecular Cell, 2020)
ISRIB blunts the Integrated Stress Response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

Raymond and Reid labs (American Journal of Human Genetics, 2020)
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment

Rayner lab (Nature, 2020)
Red blood cell tension protects against severe malaria in the Dantu blood group

Maxwell lab (Nature Immunology, 2020)
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development 

Weekes lab (PNAS, 2020)
Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor

Woods lab (Cell Reports, 2020)
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit

Deane lab (Nature Communications, 2020)
The receptor PTPRU is a redox sensitive pseudophosphatase

Rubinsztein lab (Nature Communications, 2020)
Leucine regulates autophagy via acetylation of the mTORC1 component raptor

Rubinsztein lab in collaboration with the Goldberg lab, Harvard (PNAS, 2020)
cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Griffiths lab (eLife, 2020)
Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

Buss lab (Journal of Cell Science, 2020)
OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion

Rubinsztein lab (Developmental Cell, 2020)
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy

Buss lab (Biology of Reproduction, 2020)
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis

Weekes lab (Scientific Reports, 2020)
Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes

Buss lab (Traffic, 2020)
Ultrastructural insights into pathogen clearance by autophagy

Read lab (Acta Crystallographica Section D, 2020)
Measuring and Using Information Gained by Observing Diffraction Data

Read lab (Acta Crystallographica Section D, 2020)
Factors influencing estimates of coordinate error for molecular replacement

 

2019

Ron lab (eLife, 2019)
Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Weekes lab (eLife, 2019)
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

Rubinsztein lab (eLife, 2019)
Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

Ron lab (eLife, 2019)
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

Griffiths lab (Journal of Clinical Investigation, 2019)
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

Reid lab (Frontiers in Neuroscience, 2019)
Spastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function

Deane lab (Wellcome Open Research, 2019)
The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading

Reid lab (Cellular and Molecular Life Sciences, 2019)
ESCRT‑III‑associated proteins and spastin inhibit protrudin‑dependent polarised membrane traffic

Ron lab (EMBO Journal, 2019)
An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

Robinson lab (Traffic, 2019)
Fast and cloning‐free CRISPR/Cas9‐mediated genomic editing in mammalian cells

Weekes lab (Communications Biology, 2019)
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations

St George-Hyslop lab (Cell, 2019)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Siniossoglou lab (Developmental Cell, 2019)
Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization

Weekes lab (Cell Metabolism, 2019)
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

Warren lab (Blood, 2019)
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.

Warren lab (eLife, 2019)
Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

Weekes lab (Cell Reports, 2019)
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

Rubinsztein lab (Nature Communications, 2019)
Felodipine ameliorates neurodegeneration in mice

Sharpe lab (eLife, 2019)
The receptor PTPRK selectively dephosphorylates junctional regulators

Ron lab (Nature Comm, 2019)
MANF anatagonizes nucleotide exchange by the enodplasmic reticulum chaperone BiP