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Cambridge Institute for Medical Research
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Alpha-synuclein mutations mislocalise cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 anti-trypsin deficiency
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
VAMP2 regulates phase separation of α-synuclein
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle
The ALBORADA Drug Discovery Institute
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Intranet (CIMR only)
Dept. of Clinical Biochemistry
Cambridge Institute for Medical Research
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Intranet (CIMR only)
Read more
at: Katherine Webber
Katherine Webber
Read more
at: Katty Wadda
Katty Wadda
Read more
at: Allan Muhwezi
Allan Muhwezi
Read more
at: Balanding Manneh
Balanding Manneh
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at: Dr Chris Bower-Lepts
Dr Chris Bower-Lepts
Read more
at: Ioana Sava
Ioana Sava
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at: Jessica Eden
Jessica Eden
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at: Alex Holmes
Alex Holmes
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at: Mrs Sue Arden
Mrs Sue Arden
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at: Dr Zuzana Kadlecova
Dr Zuzana Kadlecova
Integration of NAK kinases with membrane trafficking machinery
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