Ko D, Ruonala R, Faille A*, Hellmann E, Help H, Liu H, Nielsen R, Haakonsson A, De Diego N, Paatero A, Shcherbii MV, Stefanowicz K, Ćavar Zeljković S, Drud Lundager Rasmussen T, Novak O, Bodi Z, Eswaran G, Wybouw B, Bourdon M, Urbez C, Liu X, Salokas K, Öhman T, Waldie T, Törönen P, El-Showk S, Balcerowicz M, Besnard F, Liu X, Perkins P, Mazzoni-Putman S, Vainonen JP, Sierla M, Frilander MJ, Mandrup S, Vernoux T, Ljung K, Ferrando A, Blazquez MA, Holm L, Fray R, Varjosalo M, Leyser O, Paavilainen VO, Mähönen AP, Stepanova A, Alonso J, Heber S, Malinowski R, Kirpekar F*, Warren AJ*, Helariutta Y*. Science. 2026 Feb 12;391(6786):694-699. doi: 10.1126/science.adx2867. Epub 2026 Feb 12. PMID: 41678627 *Joint Corresponding Authors.
Gordon J, Kaminksi AM, Bommu SR, Skrajna A, Petrovich RM, Pedersen LC, McGinty RK, Warren AJ*, Stanley RE*. PELP1 Modularly Regulates the Assembly and Enzymatic Activity of the RNA Rixosome. Sci Adv. 2025 Jul 25;11(30):eadw4603. doi: 10.1126/sciadv.adw4603. *Joint corresponding authors. PMID: 40712028
Machado HE, Øbro NF, Williams N, Tan S, Boukerrou AZ, Davies M, Belmonte M, Mitchell E, Baxter EJ, Mende N, Clay A, Ancliff P, Köglmeier J, Killick SB, Kulasekararaj A, Meyer S, Laurenti E, Campbell PJ, Kent DK, Nangalia J, Warren AJ. Convergent somatic evolution commences in utero in a germline ribosomopathy. Nature Communications2023 https://doi.org/10.1038/s41467-023-40896-5. PMID: 37608017
Pellegrino S, Dent KC, Spikes T, Warren AJ. Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 Å resolution. Nucleic Acids Research, 2023 May 8;51(8):4043-4054. doi: 10.1093/nar/gkad194. PMID: 36951107
Prattes M, Grishkovskaya I, Hodirnau V-V, Hetzmannseder C, Zisser G, Sailer C, Vasileios Kargas, Loibl M, Gerhalter M, Kofler L, Warren AJ, Stengel F, Haselbach D and Bergler H. Structure of the AAA-ATPase Drg1 during extraction of Rlp24 from pre-60S particles. Nature Structural and Molecular Biology, 2022 Sep;29(9):942-953. doi: 10.1038/s41594-022-00832-5. Epub 2022 Sep 12. PMID: 36097293
Jaako P, Faille A, Tan S, Wong CC, Escudero-Urquijo N, Castro-Hartmann P, Wright P, Hilcenko C, Adams DJ, Warren AJ. eIF6 rebinding dynamically couples ribosome maturation and translation. Nature Communications 13, 1562 (2022). https://doi.org/10.1038/s41467-022-29214-7. PMID: 35322020
Tan S, Kermasson L, Hilcenko C, Kargas V, Traynor D, Boukerrou AZ, N Escudero-Urquijo, Faille A, Rossmann M, Goyenechea B, Bertrand A, Moreil J, Alibeu O, Beaupain B, Bôle-Feysot C, Fumagalli S, Kaltenbach S, Martignoles J-A, Masson C, Nitschké P, Parisot M, Pouliet A, Radford-Weiss I, Tores F, de Villartay J-P, Zarhrate M, Koh AL, Phua KB, Revesade B, Bond PJ, Bellanné-Chantelot C, Callebaut I, Delhommeau F, Donadieu J, Warren AJ* and Revy P*. Somatic genetic rescue of a germline ribosome assembly defect. Nature Communications (2021) Aug 19;12(1):5044. doi: 10.1038/s41467-021-24999-5. PMID: 34413298. *Joint Senior authors
Tan S, Kermasson L, Hoslin A, Jaako P, Faille A, Acevedo-Arenzana A, Lengline E, Ranta D, Poirée, M, Fenneteau O, Ducou le Pointe H, Fumagalli S, Beaupain B, Nitschke P, Bôle-Feysot C, de Villartay J-P, Bellanné-Chantelot C, Donadieu J, Kannengiesser C, Warren AJ*, and Revy P*. EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome. Blood 2019 Jul 18;134(3):277-290. doi: 10.1182/blood.2018893404. Epub 2019 May 31. *Joint corresponding authors. PMID: 31151987
Kargas V, Castro-Hartmann P, Escudero-Urquijo N, Dent K, Carvalho M, Sailer C, Zisser G, Hilcenko C, Freund S, Wagstaff J, Andreeva A, Faille A, Chen E, Stengel F, Bergler H, Warren AJ. Mechanism of completion of peptidyltransferase centre assembly in eukaryotes. Elife, 2019 May 22;8:e44904. doi: 10.7554/eLife.44904. PMID: 31115337
Zyryanova AF*, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ* and Ron D*. Binding of the integrated stress response inhibitor ISRIB reveals a regulatory site in the nucleotide exchange factor, eIF2B. Science 2018 Mar 30;359 (6383):1533-1536. doi: 10.1126/science.aar5129. *Joint corresponding authors. PMID: 29599245.
Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ. Mechanism of eIF6 release from the nascent 60S ribosomal subunit. Nat Struct Mol Biol, (2015) Nov;22(11):914-9. doi: 10.1038/nsmb.3112. Epub 2015 Oct 19. PMID: 26479198.
Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ, Jin L, Packman LC, Shlien A, Campbell P, Kirwan M, Dokal I, Warren AJ. Aberrant 3’ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia. Blood. 2013 Feb 7;121(6):1028-38. doi: 10.1182/blood-2012-10-461491. Epub 2012 Nov 27. PMID: 23190533
Wong CC, Traynor D, Basse N, Kay RR, Warren AJ. Defective ribosome assembly in Shwachman-Diamond syndrome. Plenary Paper, Blood. 2011 Oct 20;118(16):4305-12. doi: 10.1182/blood-2011-06-353938. Epub 2011 Jul 29. PMID: 21803848
Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, González Fernández Á, Simpson P, D’Santos CS, Arends MJ, Donadieu J, Bellanné-Chantelot C, Costanzo M, Boone C, McKenzie AN, Freund SM, Warren AJ. Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes and Development (2011) 25: 917-929. PMID: 21536732
Barlow JL, Drynan LF, Hewett DR, Holmes LR, Lorenzo-Abalde S, Lane AL, Jolin HE, Pannell R, Middleton AJ, Wong SH, Warren AJ, Wainscoat JS, Boultwood J, McKenzie AN. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nature Medicine. (2010) Jan; 16(1): 59-66. Epub 2009 Nov 22. PMID: 19966810.
Menne TM, Goyenechea B, Sánchez-Puig N, Wong CC, Tonkin LM, Ancliff P, Brost RL, Costanzo M, Boone C and Warren AJ. The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nature Genetics (2007) 39: 486-95. PMID:17353896
Allen MD, Grummitt CG, Hilcenko, C, Young Min S, Tonkin LM, Johnson CM, Freund S, Bycroft SM, Warren AJ. Solution structure of the nonmethyl-CpG-binding CXXC domain from the leukaemia-associated MLL histone methyltransferase. EMBO J. (2006), 25: 4503-12.
Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)-CBFß complex functions as a DNA-induced molecular clamp. Nature Struct. Biol. (2001) 8: 371-8.
Warren AJ, Bravo J, Williams RL, Rabbitts TH. Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFß. EMBO J. (2000) 19: 3004-15.
Yamada Y, Warren AJ, Dobson C, Forster A, Pannell R, Rabbitts TH. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc. Natl. Acad. Sci. USA (1998) 95: 3890-95. PMID: 9520463
Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell (1994) 78: 45-57.
