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Cambridge Institute for Medical Research


YAP and TAZ are both transcriptional regulators with central roles in cell growth. Mariana Pavel, So Jung Park and colleagues from the Rubinsztein lab have discovered a feedback loop linking autophagy with YAP/TAZ signaling. Publishing in Nature Communications, the researchers show how α-catenin protein levels regulate this feedback loop. These findings explain how different cells can exhibit very different relationships between autophagy and growth pathways, highlighting a source of variation in experimental cell model and potentially guiding therapies aimed at either increasing or decreasing autophagy in different disease contexts.