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Cambridge Institute for Medical Research


With key roles in normal cellular homeostasis and a range of diseases, autophagy is mediated by autophagosomes. Using insights from a rare muscle-wasting disease, Dr Claudia Puri from the CIMR’s Rubinsztein Laboratory and colleagues present a new model for the subcellular origins of autophagosomes and their regulation. Mutations in the DNM2 (dynamin 2) gene cause some forms of autosomal dominant centronuclear myopathy (AD-CNM). Puri et al demonstrate in Developmental Cell that autophagosomes can be ‘snipped off’ tubular recycling endosome membranes in a process which requires DNM2, but which can be defective in AD-CNM.