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Cambridge Institute for Medical Research

 

Research Assistant (Fixed Term)

CIMR vacancies on www.jobs.cam.ac.uk - Tue, 16/08/2022 - 00:00

The Kadlecova lab at the Cambridge Institute for Medical Research studies the molecular regulation of endocytosis and its integration with signalling and homeostasis through phosphorylation/dephosphorylation events. Our approach is to integrate cell biology, quantitative high-resolution live-cell imaging, proteomics and biochemistry.

We are looking for a skilled and highly motivated Research Assistant to join our team.

The post holder must possess a BSc degree (or equivalent) in Cell or Molecular Biology, Biochemistry, or a related field and have practical laboratory experience.

The successful candidate will show great attention to detail and have excellent record-keeping skills. In addition, they must be a team player who can interact effectively with a wide range of staff, students and others. These skills are essential to contribute to the smooth running of the group and our collaborations. The ability to communicate work clearly in both formal and informal settings is another essential requirement of the role

We encourage applications from scientists with a background in cell or molecular biology or biochemistry and are keen on making detailed molecular insights from cell-based discoveries. The post-holder will have the opportunity to learn additional techniques and expand their research skills due to the multidisciplinary and supportive nature of the lab.

About CIMR : Located on the Cambridge Biomedical Campus, CIMR is an interdisciplinary research institute within the University of Cambridge School of Clinical Medicine. The Institute's mission is to determine the molecular mechanisms of disease in order to advance human health. To achieve this, we leverage deep collaborations between basic and clinician scientists, built on shared interests, outstanding core facilities and an inclusive, supportive working environment. See www.cimr.cam.ac.uk for more information.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal queries should be directed to Dr Zuzana Kadlekova, email zk241@cam.ac.uk .

Please quote reference SG32761 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Receptionist (Part Time)

CIMR vacancies on www.jobs.cam.ac.uk - Tue, 26/07/2022 - 00:00

The Keith Peters Building houses the Cambridge Institute for Medical Research (CIMR) and the MRC Mitochondrial Biology Unit (MBU). These form part of the University of Cambridge Clinical School based on the Cambridge Biomedical Campus.

An opportunity has arisen to join a team of four Receptionists who provide that all-important first point of contact for incoming telephone calls and visitors to the Building. The role will also be involved in sorting mail, organising room bookings, maintaining the security card database and other general reception duties.

Hours worked are on a shift pattern of two days one week and three days the next averaging 16 hours per week (08.00-15.00 hours or 09.15-17.00 hours, depending on shift). The days worked are not the same each week, but the rota is organised in advance allowing you to know when you will be working. You will also be expected to cover for holiday and sickness absence as and when required, reimbursed by overtime payments.

You will possess good interpersonal skills, have a welcoming, positive and polite manner and a smart appearance (a uniform will be provided). Basic IT skills would be an advantage and in-house training will be provided. Flexibility and team-work are essential to making this role a success.

Further information about the role including role overview, duties, responsibilities and person specification are available below. Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

The University of Cambridge has implemented a University of Cambridge Living Wage, which sets a minimum rate of pay of £10/hour for all employees (equal to a full-time annual salary of £19,071 based on a 36.5 hour week). The University will pay this as a supplement for the difference between the base hourly rate and the University of Cambridge Living Wage.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries about the role, contact: Charlotte Yelton, HR Supervisor, email caay2@cam.ac.uk

Please quote reference SA32403 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant (Part Time, Fixed Term)

CIMR vacancies on www.jobs.cam.ac.uk - Fri, 22/07/2022 - 00:00

A part-time research assistant position is available in the Rayner lab https://www.cimr.cam.ac.uk/staff/professor-julian-rayner to work on a project studying host-parasite interactions during red blood cell invasion by Plasmodium falciparum parasites. Your work will focus on generating genetic modification vectors and using them to create transgenic P. falciparum parasites lines. You will work as part of a vibrant interdisciplinary team which seeks to understand the interactions between Plasmodium parasites and human red blood cells in order to identify and prioritise new drug and vaccine targets, and in close collaboration with partners and colleagues within CIMR, other Cambridge departments and as researchers in malaria endemic countries.

Applicants must hold an undergraduate degree in a science subject. Experience in culturing and phenotyping Plasmodium falciparum parasites is highly desirable, but not absolutely essential, and those with genetics and cell biology experience in other eukaryotic cell systems who want to make a career transition into malaria research are also encouraged to apply. You must be highly collaborative and team-oriented in your approach to research, with excellent oral and written communication skills.

This is a part-time role with the potential for flexible working, so could be the ideal opportunity for talented scientists seeking to return to work after a career gap, or who want to work part-time in research while balancing other responsibilities. While there is some flexibility with the scheduling of work tasks, because malaria parasites grow on a 48 hour life cycle there is not complete flexibility, as some tasks must be carried out at specific points in that cycle. The ideal schedule would be to work for a shorter number of hours (e.g. 9am ¿ 2pm) on multiple days of the week, rather than for longer number of hours on a smaller number of days. Being present for at least some hours on both Mondays and Fridays is essential. Funding is available for up to 60% of a full-time role (approx. 22 hours/week).

Research will be carried out at the Cambridge Institute for Medical Research (CIMR), an interdisciplinary research institute which is part of the University of Cambridge, School of Clinical Medicine and located on the Cambridge Biomedical Campus. CIMR's mission is to explore the molecular mechanisms of disease in order to advance human health (https://www.cimr.cam.ac.uk). Our approach is to bring together fundamental and clinical researchers who have shared interests in cellular homeostasis and how it is disrupted in genetic and infectious diseases, and support their work with outstanding core facilities and a highly collaborative, collegial working environment. We are committed to diversity, inclusion and anti-racism, and applicants from groups that are under-represented in scientific research are particularly encouraged to apply.

Fixed-term: The funds for this post are available until 31 December 2025 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal queries should be directed to Professor Julian Rayner, email jcr1003@cam.ac.uk.

Please quote reference SG32357 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

CIMR vacancies on www.jobs.cam.ac.uk - Wed, 20/07/2022 - 00:00

The ALBORADA Drug Discovery Institute (DDI) is seeking talented chemists to expand its medicinal chemistry team.

The Cambridge DDI is part of a network of world-class Drug Discovery Institutes funded by Alzheimer's Research UK and prosecutes drug discovery projects from target to in vivo proof of concept and beyond for novel targets in the neurodegeneration therapeutic area. This is an exciting opportunity to join this institute based on the prestigious Cambridge Biomedical Campus.

The successful applicant(s) will have a PhD in a relevant specialist subject or have equivalent qualifications or experience. They will have a flair for problem solving and a track record of delivering solutions to challenging chemical problems.

Moreover, they will have excellent communication skills and a willingness to work as part of a team in order to drive forward collaborative projects.

We welcome applications from candidates with purely synthetic chemistry experience or from a biological or medicinal chemistry background. The successful candidate(s) will work in a stimulating and collaborative environment with opportunities for training and development.

Specific enquiries about the post may be addressed to Steve Andrews (spa26@cam.ac.uk).

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Fixed-term: The funds for this post are available until 31 October 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SA32309 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Assistant (Fixed Term)

CIMR vacancies on www.jobs.cam.ac.uk - Tue, 19/07/2022 - 00:00

We are seeking to recruit an energetic and well organised person to manage a busy Wellcome Trust funded laboratory and facilitate ongoing research projects within the group. The research group is part of the Cambridge Institute for Medical Research on the Cambridge Biomedical Campus. The lab works on the molecular mechanisms that control killing by cytotoxic T lymphocytes, important cells of the immune system that kill virally infected and cancer cells. Our research combines cell biology and immunology, using genetic approaches including CRISPR and single cell RNA sequencing of primary lymphocytes, together with high-resolution imaging.

The holder of the post will play a key role in the smooth running of the laboratory, particularly managing the organisation of the lab, responsibility for databases, ordering, orientating new staff, working with students (undergraduate and postgraduate) and supporting research projects in the laboratory as necessary.

The applicant must be a graduate in a scientific subject and several years' experience working within a biological laboratory environment would be preferable. We are seeking someone who will be able to oversee the general running of the lab and facilitate the work of the scientists within it. This will involve assisting with experiments, but also ensuring that the lab runs smoothly day-to-day. There is flexibility within this role that could be possible for applicants with experience requiring part-time working.

Core tasks will include but would not be limited to:

Assisting with experiments (e.g., molecular biology, cell culture, flow cytometry).

Placing orders and liasing with company reps to negotiate prices.

Maintenance and cataloging of lab stocks (e.g., plasmids and cell lines) Keeping task assessments up to date.

Management of laboratory equipment.

Fixed-term: The funds for this post are available until 31 August 2024 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal queries should be directed to Professor Gillian Griffiths, email gg305@cam.ac.uk . Interviews will be taking place at the end of August.

Please quote reference SC32287 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Laboratory Assistant

CIMR vacancies on www.jobs.cam.ac.uk - Mon, 18/07/2022 - 00:00

A Laboratory Assistant is required to provide general support to the Laboratory Management Team within the Cambridge Institute for Medical Research.

Working in the Glasswash facility and on the CIMR Levels, the duties include the collection and return of laboratory glass and plastic ware; loading and unloading of large autoclaves and glass-wash machines; assisting with the stocking of the core Tissue Culture Labs within CIMR; advising others of low stock/assisting with stock control; maintaining general tidiness of the core labs, and cleaning and care of apparatus under their control.

Reporting to the CIMR Level Coordinator, the role holder will alert the Coordinator of breakdowns and alarms and assist in rectifying problems under the guidance/instruction of the Coordinator.

As part of the Lab Support Team, the role also involves covering for absences of staff of commensurate grade as required, including delivery of packages and parcels from Goods-in to the Labs/Offices as well as providing absence cover for the Glasswash Technician and the Assistant Level Coordinator.

Hours of work: 0730-1530, Monday-Thursday, 0730-1430, Friday (30 minutes lunch each day). Part-time working would be considered but must be a minimum of 0.8FTE over 5 days and the role is required to start at 7.30am.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

The University of Cambridge has implemented a University of Cambridge Living Wage, which sets a minimum rate of pay of £10/hour for all employees (equal to a full-time annual salary of £19,071 based on a 36.5 hour week). The University will pay this as a supplement for the difference between the base hourly rate and the University of Cambridge Living Wage.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. Please see role requirements above.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries about the role, contact: Dave Cheesman, Lab & Facilities Manager, email djc69@cam.ac.uk

For questions regarding the application process, contact: Charlotte Yelton, HR Supervisor, email caay2@cam.ac.uk

Please quote reference SA32243 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Head of Biology (Director of Research)

CIMR vacancies on www.jobs.cam.ac.uk - Wed, 29/06/2022 - 00:00

Head of Biology

The ALBORADA Drug Discovery Institute (ADDI) at the University of Cambridge is seeking an innovative, creative and experienced neuroscientist to lead and develop the institute's biology team and contribute to the vision and direction of this prestigious venture. The ADDI is a multidisciplinary group of biologists and chemists developing new therapies for neurodegenerative diseases. The biology group comprises cell and molecular neurobiologists, assay development and screening scientists and an in vivo biology team each supported by experienced team leaders and fully equipped laboratory space.

As Head of Biology you will be the most senior biologist in the ADDI team and will report to, and work in partnership with, the Chief Scientific Officer and along with the Head of Chemistry and Lead Academic Scientist, be a member of the institute's senior leadership team with the overall objective of establishing and delivering on projects, moving them towards the clinic through partnership with industry and growing the institute's research budget.

You will be responsible for the scientific output and development of the biology group and will have line-management responsibility for a portfolio of projects as well as staff and budgets. Through interaction with Prof Roger Barker, the institute's Lead Academic Scientist, you will help shape our developing clinical strategy and use of human data.

Scientifically, you will take a leading role in the identification and development of new targets and projects and will be encouraged to develop new concepts and approaches. The successful applicant may come from industry or academia, is expected to bring access to a network of potential collaborators and will be strongly encouraged to develop opportunities and new partnerships. You will be supported in raising further funding through grant applications or venture capital to develop projects and explore new hypotheses.

The successful applicant will have a PhD and relevant translational research and leadership expertise. You are expected to have an excellent understanding of mechanisms underpinning neurodegenerative disease and a good appreciation of the importance of omics and human data to target identification.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 15th August 2022

First stage interviews will take place: w/c 5th September, although this could be subject to change.

For an informal discussion in confidence please contact our recruitment partner Roger Russell at Penna on 07710 701 570 or email roger.russell@penna.com

Applications, consisting of a letter of application, a statement of current and future research plans, a curriculum vitae, and a publications list, along with details of three referees should be submitted online via the University Cambridge jobs page www.jobs.cam.ac.uk by clicking 'Apply online' in the job advert.

Please quote reference SA31994 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate in Protein Biochemistry (Fixed Term)

CIMR vacancies on www.jobs.cam.ac.uk - Tue, 14/06/2022 - 00:00

We have an exciting opportunity for a postdoctoral Research Associate to join our team studying the molecular mechanisms linking lysosomal dysfunction to neurodegenerative diseases. This is a Wellcome Trust-funded post in the laboratory of Dr Janet Deane at the Cambridge Institute for Medical Research. We encourage applications from scientists with a background in protein and/or lipid biochemistry who have a keen interest in developing cell-based discoveries into molecular insights.

The post holder must possess a PhD in Biochemistry, Molecular Biology or a relevant subject. Experience in protein expression and purification is essential as well as some experience with protein interaction techniques such as pulldown assays, SPR or ITC. Experience with membrane protein function or lipid biochemistry and an understanding of membrane trafficking would be advantageous.

The candidate must have a proven track record of generating publication-quality data, great attention to detail and excellent record keeping. They must also have good interpersonal skills as well as the ability to communicate their work clearly in both formal and informal settings.

The successful applicant will be part of a team with established expertise in protein purification, protein-protein and protein-lipid interaction assays, structural biology and the generation of cell-based models of disease including CRISPRi in iPSC cells. Due to the supportive nature of the laboratory enthusiastic candidates will have the oportunity to learn additional techniques and expand their research skills. Furthermore, we encourage creative thinking when tackling scientific problems and are keen for lab members to adopt new technologies and approaches when appropriate.

Fixed-term: The funds for this post are available until 14 April 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries please contact Dr Janet Deane at jed55@cam.ac.uk .

Please quote reference SD30506 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.