CIMR vacancies on www.jobs.cam.ac.uk

We are looking for a Research Associate to join the group of Prof Read in the Cambridge Institute for Medical Research (https://www.cimr.cam.ac.uk), based at the Addenbrookes Bio-Medical Campus in Cambridge. The well-established project develops mathematical methods and software for the imaging of biological molecules. The software supports academic and pharmaceutical R&D worldwide.

The project will be focused on statistical approaches to structural biology using likelihood, with an emphasis on developing a common framework for crystallographic and cryo-EM approaches to investigating 3D structure. A key aspect will be accelerating the calculations and extending their applicability by using multi-threaded CPU and GPU hardware.

For more information on the research group see https://www.cimr.cam.ac.uk/staff/professor-randy-j-read-frs, and details of the Phaser project can be found at https://www.phaser.cimr.cam.ac.uk/.

Qualifications and Experience: PhD, with a strong interest in methods and applications of structural biology. Preference will be given to candidates with experience in macromolecular crystallography or cryo-EM and to those with experience programming in languages such as Python and C++.

Fixed-term: The funds for this post are available until 31 May 2024 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For further details on the project please contact Prof Randy Read on rjr27@cam.ac.uk.

Please quote reference SB36089 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Cambridge Institute for Medical Research (CIMR) is seeking to recruit an enthusiastic and skilled individual to plan, support and deliver impactful and strategy-led Public Engagement (PE) and Communications Coordinator at the Institute.

CIMR is a cross-department research institute in the University of Cambridge's School of Clinical Medicine. At the interface between laboratory research and the clinic, CIMR's mission is to determine the molecular mechanisms of disease in order to advance human health.

Communicating and sharing what we do is an important component of this mission. CIMR's PE vision is to foster a culture of two-way research engagement within the Institute and to increase knowledge and understanding of the Institute's research among diverse public groups and patient audiences through the provision of accessible information. The role-holder will be the lead person on this engagement while also supporting the delivery of a broader Communications strategy for external and internal audiences ranging from keeping CIMR's website up to date, (co-)producing short CIMR research updates for general audiences, to producing CIMR's internal newsletter for all staff and students.

The role-holder will also liaise with key PE, Public & Patient Involvement (PPI) and Communications leads across the Schools of Clinical Medicine and wider University to ensure that CIMR Public Engagement and Communications remain well-connected, informed and collaborative.

Reporting to CIMR's Scientific Research Strategy Manager, the successful candidate will play a key role in ensuring that engaging external and internal Communications are a feature of CIMR, and that meaningful engagement with diverse public audiences is seen as an essential part of research.

The role's working pattern would be agreed in line with business needs and the events schedule. However, there is some flexibility regarding the level of part-time working hours which could vary between around 0.6 FTE to 0.8 FTE. As there is a limited funding source for the role, the role's exact duration will be dependent on the finally-agreed levels of FTE and salary, but in the first instance the role is expected to be for between around two and three years maximum. There is an expectation that further funding will be sought by CIMR to extend the position to become a longer-term feature of the Institute. There will also be a degree of hybrid (home / CIMR office) working possible with the role.

Expected interview date: Friday 12th May 2023 Candidates invited for interview will be asked to complete a pre-interview written task.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements as noted above.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Dr Simon Ridley, Scientific Research Strategy Manager via shr20@cam.ac.uk.

If you have any queries regarding the application process, please contact Charlotte Yelton, HR Supervisor, caay2@cam.ac.uk.

Please quote reference SA33593 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

A PhD studentship is available to start in October 2023 at the Cambridge Institute for Medical Research (CIMR). The mission of CIMR is to determine the molecular mechanisms of disease in order to advance human health. Bringing together outstanding fundamental and clinical researchers, we focus on central pathways of cellular homeostasis and how they are disrupted in genetic and infectious disease. We have a particular focus on rare genetic diseases, an area of great unmet clinical need. CIMR is known for its positive research culture.

The Hazel Satchell Studentship is supported by a generous philanthropic gift and will focus on investigating the molecular cell biology of a group of genetic neurological conditions called hereditary spastic paraplegias, specifically a subtype that is caused by mutations in a mitochondrial protein called SPG7. This studentship is based in the group of Professor Evan Reid at CIMR and will fund a tax free stipend for 3.5 years (starting at £20,168/year), University fees at the home rate and laboratory consumables.

The project will be carried out in collaboration with the laboratory of Professor Patrick Chinnery, a leading expert in mitochondrial biology. It will appeal to candidates who wish to have training in the state-of-the-art cell biological techniques that can be used to understand the molecular mechanisms of rare disease.

The project aims to understand the functions of SPG7 in the molecular pathogenesis of axonal degeneration. The work will be at the interface between cell biology and molecular neuroscience, and will begin with functional genomic synthetic lethality screens using iPSC-derived neuronal models of SPG7, to identify key pathways involved in the disease. The lab employs an integrated approach that combines state of the art cell biology, biochemistry, proteomics, functional genomics and stem cell-derived neuronal modeling. We aim to produce high quality research that impacts our field and stands the test of time.

Candidates must have experience in molecular cell biology or molecular neuroscience, and must by the time of appointment have a BSc (at least 2i) in a biomedical science-related subject. Previous research experience, for example via a Master's degree, would be desirable, especially if in a topic related to understanding the molecular cell biological mechanisms of genetic disease.

Applicants will work under the strategic supervision of Professors Reid and Chinnery to achieve the aims of this project. They will work closely with a second PhD student who is carrying out a complementary project looking at other aspects of SPG7 biology, so effective team working is an important requirement. They will work within a highly interactive group, have a friendly and collegiate outlook, good written and verbal communications skills, be well-organised and have the ability to work calmly to meet deadlines.

To be eligible to apply, students must: · meet University of Cambridge 'Home student' admission requirements (details: https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status ) · have, or are be expected to attain at least an upper second class honours degree in a relevant biological sciences subject · command English language skills that meet the minimum requirements https://www.postgraduate.study.cam.ac.uk/international/competence-english .

There is a two-step application process for this studentship. First, candidates must download and email the completed application form (see document below) and return it with a CV with the names and contact details of two academic references to Amanda Goldsmith, phdadmin@cimr.cam.ac.uk , by 12pm on Thursday 6th April 2023. Shortlisted candidates will be invited to interview in April.

Following interview, the successful candidate will be invited to apply online to Postgraduate Admissions the University of Cambridge. They will receive information on how to do this at the time.

General enquiries about the studentship can be made to phdadmin@cimr.cam.ac.uk

Please quote reference SE35740 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society, particularly from groups who are historically under-represented in research.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic, motivated individual for a position in the group of Prof. Mike Weekes, in Cambridge Institute for Medical Research at the Cambridge Biomedical Campus. You will join an exciting research programme aiming to identify novel therapeutic targets against human cytomegalovirus (HCMV). This post will involve the use of cutting edge proteomic, structural and biochemical techniques to characterise interactions between HCMV and degraded antiviral restriction factors, determine how these influence viral replication and how this might be prevented therapeutically.

This position is available for immediate appointment. Candidates must either have a PhD in a relevant biological subject, or be writing a PhD thesis. Candidates must also have demonstrable expertise in virology, cell biology, structural biology and/or molecular biology. Additional training in proteomics will be provided. Relevant post-doctoral experience is desirable. High quality peer-reviewed publications and a keen interest in viral / cellular regulation are essential.

If you have an excellent background in biological sciences, are prepared to face intellectual challenges and wish to develop your scientific skills, we would like to hear from you. Applicants should have outstanding organisation and communication skills, and work well as part of a team.

Fixed-term: The funds for this post are available for 2 years in the first instance.

For recent related publications, see:

Nightingale et al. (2018) Cell Host & Microbe doi: 10.1016/j.chom.2018.07.011 Nobre et al. (2019) eLife: doi: 10.7554/eLife.49894 Fletcher-Etherington et al. (2020) PNAS: doi: 10.1073/pnas.2001887117 Nightingale et al. (2022) PNAS doi: 10.1073/pnas.2108173119

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries to Prof. Mike Weekes: mpw1001@cam.ac.uk .

Interview taking place on Thursday 9th March 2023.

Please quote reference SC35147 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for an enthusiastic and committed graduate Research Assistant to join a vibrant team investigating the cell biology of a group of neurological conditions called hereditary spastic paraplegias. This project is based in the group of Professor Evan Reid at Cambridge Institute for Medical Research and is funded for 2 years. It would suit a recent biological sciences graduate who would like to obtain more practical laboratory experience before embarking on a PhD.

The project aims to understand the functions of hereditary spastic paraplegia proteins in the molecular pathogenesis of axonal degeneration. The work will be at the interface between cell biology (especially membrane traffic) and molecular neuroscience, and will begin with functional genomic synthetic lethality screens using iPSC-derived neuronal models of HSP. The lab employs an integrated approach that combines state of the art cell biology, biochemistry, proteomics, functional genomics and stem cell-derived neuronal modeling.

We aim to produce high quality research that impacts our field and stands the test of time. Cambridge Institute for Medical Research is a centre of excellence that has a strong focus on understanding the molecular mechanisms of disease, with the aim of translating basic discoveries to clinically meaningful therapies. It is known for its positive research culture.

Candidates must have experience in molecular cell biology or molecular neuroscience, and must by the time of appointment have a BSc in the biological, biochemical or biomedical sciences. Previous research experience would be highly desirable, especially if in one of the following areas; CRISPR-Cas genome editing, stem cell culture and neuronal differentiation, fixed or live cell immunofluorescence microscopy (especially super-resolution), lentiviral delivery of RNA or DNA to cultured cells.

Applicants will work under the practical supervision of a post-doctoral researcher to achieve the aims of this project. They will be expected to work within a highly interactive group, to have a friendly and collegiate outlook, to have good written and verbal communications skills, to be well-organised and have the ability to work calmly to meet deadlines.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Professor Evan Reid, email ealr4@cam.ac.uk

If you have any queries regarding the application process, please contact Charlotte Yelton, HR Supervisor, on caay2@cam.ac.uk

Please quote reference SE35065 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An opportunity has arisen to join the Accounts & Purchasing team in the Cambridge Institute for Medical Research (CIMR). This is a varied role that includes placing purchase orders, processing accounts payable and receivable and dealing with queries from colleagues and suppliers. You will be ready to aid other team members in providing a first class accounts service to the institute's scientists, which may include covering other tasks such as checking and processing expense claims. You will need to be flexible and be able to cover tasks during holiday, sickness and holiday periods.

You should be educated to GCSE Grade C (or equivalent) in English and Maths, possess excellent interpersonal skills and have the ability to maintain accuracy when working to tight deadlines. An AAT Foundation/Introductory qualification would be an advantage.

CIMR is located on the Cambridge Biomedical Campus and forms part of the University of Cambridge School of Clinical Medicine. We provide modern laboratory accommodation and state of the art research facilities for the Institute's researchers who study the molecular mechanisms of disease. The researchers are all supported by an administration team who cover HR, Finance, IT, Building Services and Laboratory Management to ensure that the Institute runs smoothly.

The closing date for applications is Sunday 12th February 2023 and interviews will take place in the week starting 20th February 2023.

The position is available immediately.

We welcome applications from individuals who wish to be considered for flexible working arrangements. We are looking for someone to work approximately 30 hours per week, and there is flexibility over the exact number of hours worked and which days (Monday-Friday).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Aga Lanucha, Accounts & Purchasing Supervisor al512@cam.ac.uk

If you have any queries regarding the application process, please contact Charlotte Yelton, HR Supervisor, on caay2@cam.ac.uk

Please quote reference SA34979 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Investigating novel therapeutic targets of liver disease in alpha-1 antitrypsin deficiency

We are seeking a Research Assistant to join our lab in The Cambridge Institute for Medical Research (CIMR) to study the mechanism of action of exciting new treatment strategies. Applicants are expected to have laboratory experience and a degree in a biological science. Expertise in mammalian cell culture is essential. Experience in proteomics, flow cytometry, CRISPR-Cas9 gene editing, RT-PCR, confocal microscopy and stem cells culture and differentiation would be advantageous, but training will be provided if required.

Alpha-1-antitrypsin deficiency is an important monogenic disease affecting over 3.4 million people and is the most common genetic cause of childhood liver disease. The commonest pathogenic mutation of alpha-1 antitrypsin, named the Z allele, is overrepresented in patients requiring liver transplantation for either nonalcoholic steatohepatitis or alcoholic liver cirrhosis, highlighting its role in common diseases. Treatment of alpha-1 antitrypsin deficiency related liver disease is currently limited liver transplantation, highlighting an acute need for both novel therapeutic targets and insight into mechanisms of pathology.

The Marciniak lab combines cell biology, biochemistry, and translational medicine to understand the role of proteotoxicity in human disease (https://www.cimr.cam.ac.uk/staff/professor-stefan-marciniak).

Fixed-term: The funds for this post are available for 1 years in the first instance.

Recent relevant papers include

Chambers JE, Zubkov N, Kubánková M, Nixon-Abell J, Mela I, Abreu S, Schwiening M, Lavarda G, López-Duarte I, Dickens JA, Torres T., Kaminski CF, Holt LJ, Avezov E., Huntington JA, St George Hyslop P, Kuimova MK, Marciniak SJ. (2022). Z-alpha-1 antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state. Science Advances 8:eabm2094. doi: 10.1126/sciadv.abm2094.

Ordonez A, Harding HP, Marciniak SJ, Ron D (2021). Cargo receptor-assisted endoplasmic reticulum export of pathogenic alpha1-antitrypsin polymers. Cell Reports doi: 10.1016/j.celrep.2021.10914

Chambers JE, Kubankova M, Huber, R, López-Duart I, Avezov E, Bond P., Marciniak SJ, Kuimova, M (2018) An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles. ACS Nano 12:4398-4407. *Joint senior

Holcman D, Parutto P, Chambers JE, Fantham M, Young LJ, Marciniak SJ, Kaminski CF, Ron D, Avezov E. (2018). Single particle trajectories reveal active endoplasmic reticulum luminal flow. Nat Cell Biol 20:1118-1125 doi: 10.1038/s41556-018-0192-2

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please contact Professor Stefan Marciniak at sjm20@cam.ac.uk and Dr Joe Chambers at jec202@cam.ac.uk for further information.

Please quote reference SC34930 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a post-doctoral position in the group of Dr Janin Lautenschläger at the Cambridge Institute for Medical Research (CIMR, Biomedical Campus, University of Cambridge). Our lab studies the function of alpha-synuclein, a synaptic protein involved in Parkinson's disease. We have shown that alpha-synuclein undergoes protein phase separation and are now aiming to understand how alpha-synuclein phase separation is regulated and which functional role this plays in synaptic transmission.

The successful candidate would have a strong interest in molecular mechanisms of neurodegeneration and experience with iPSC-derived neuronal cultures including viral transgene expression and CRISPR/Cas9 gene editing. In addition, experience in molecular biology (i.e. molecular cloning, Western blot) and in microscopy are essential. Experience in advanced imaging i.e. FRAP, ratiometric dyes like Synapto-pHluorin, Airyscan, SIM and/or FLIM would be beneficial. We will be starting to work with alpha-synuclein triplication, knock-out and isogenic control iPSC-derived neurons and aim to develop further models to study the functional output of decreased/increased alpha-synuclein phase separation.

A PhD in Molecular Neuroscience (or soon to be awarded) or similar areas is essential. The candidate will be able to independently manage time and experiments to generate data for publication, as supported by a track record of peer-reviewed papers. The candidate will be able to troubleshoot experiments and develop novel research approaches/ideas.

Please submit your C.V. and a cover letter describing how you match the criteria for the post and why you are applying for this role.

Fixed-term: The funds for this post are available for 24 months in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

We are looking forward to your application, further info can be obtained from Dr Janin Lautenschlaeger jl865@cam.ac.uk .

Please quote reference SD34915 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Marciniak group (https://www.med.cam.ac.uk/marciniak/) based in the Cambridge Institute for Medical Research is seeking a bioinformatician to analyse large datasets derived from models of pleural mesothelioma. In collaboration with Dr Garnett (Wellcome Trust Sanger Institute) and Prof Rintoul (CRUK Cambridge Cancer Centre), you will analyse genomic and transcriptomic data in combination with CRISPR and drug screens to identify novel therapeutic targets in mesothelioma. The ability to analyse multiomics data in essential. Experience with single cell transcriptomic analysis would be advantageous. We will consider applicants at post-doctoral (PhD) or research assistant (Bachelor's degree) level.

The successful applicant will join a diverse team of basic and translational scientists and clinicians across the wider Cancer Research UK Cambridge Cancer Centre (Thoracic Cancer Programme). We are committed to promoting an exciting, rewarding and healthy working environment and strive to support the career goals of our team members.

Recent relevant papers include: Marciniak SJ, Chambers JE, Ron D (2022). Pharmacological targeting of endoplasmic reticulum stress in disease. Nat Rev Drug Discov. 21: 115-140

Obacz J, Nibhani R, Adams TS, Schupp JC, Valer JA, Veale N, Aresu G, Coonar AS, Peryt A, Biffi G, Kaminski N, Francies H, Rassl DM, MJ, Rintoul RC, Stefan J. Marciniak (2022). Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma bioRxiv 2022.12.03.518966; doi: https://doi.org/10.1101/2022.12.03.518966

Shamseddin M, Obacz J, Garnett MJ, Rintoul RC, Francies HE, Marciniak SJ (2021). The use of preclinical models for malignant pleural mesothelioma. Thorax 76(11):1154-1162

Obacz J, Yung H, Shamseddin M, Linnane E, Liu X, Azad AA, Rassl DM, Fairen-Jimenez D, Rintoul RC, Nikoli¿ MZ, Marciniak SJ. Biological basis for novel mesothelioma therapies. Br J Cancer. 2021 Oct;125(8):1039-1055.

Fixed-term: The funds for this post are available for 1 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please contact Professor Stefan Marciniak at sjm20@cam.ac.uk and Professor Robert Rintoul at rcr39@cam.ac.uk for further information.

Please quote reference SC34890 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Woods group at Cambridge Institute for Medical Research https://www.cimr.cam.ac.uk/ is seeking an enthusiastic Research Associate in molecular genetics.

The main focus of the Woods lab is understanding the Mendelian genetics of human pain; people born unable to feel pain, chronic pain states and visceral pain. Alongside wet lab work using molecular and cellular biology technics, the Woods group studies are primarily translational starting from classifying families suffering from Mendelian disorder of pain, discovering the causative gene and studying its pathogenicity to, finally, offering clinical support and molecular genetic diagnosis through the NHS https://www.cimr.cam.ac.uk/staff/professor-geoff-woods

The Woods group has extensive collaborations within the world of human and mammalian pain research and with Pharmaceutical industry. The successful candidate will benefit from multi-disciplinary collaborations and exciting preliminary findings.

Candidates will, by the time of appointment, have a PhD in a molecular genetics or neuroscience, with additional postdoctoral experience being highly desirable. The candidate should be enthusiastic about collaborative and interdisciplinary research. The particular skills we need are Molecular Genetics methodologies including cloning, Northern blotting, Mendelian bioinformatic analysis of genomes and exomes, and nucleic acid and protein interaction assays. Previous experience in nociception research would be useful but is not essential.

Fixed-term: The funds for this post are available for 2 years.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Professor Geoff Woods on cw347@cam.ac.uk

If you have any queries regarding the application process, please contact Charlotte Yelton, HR Supervisor, on caay2@cam.ac.uk

Please quote reference SE34800 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

An exciting opportunity has arisen for a Senior Laboratory Support Technician (SLST) to join the CIMR Laboratory Management Team. This role is ideal for someone looking to develop his or her career in Laboratory Management.

Joining a small team consisting of a Grade 6 Senior Coordinator of Technical Services, an Assistant Coordinator (Grade 3) and a Research Support Technician (Grade 2), you will provide support and assistance for the communal laboratory facilities. These include Tissue Culture labs, Containment Level 2/Blood Handling labs, Radioactive Tissue Culture, Core Equipment rooms (including centrifuges, spectrometers, orbital incubators, PCR machines, gel documentation systems etc.), cold rooms and dark rooms. You will also be responsible for negotiating discounts on consumables, arranging maintenance and repairs of laboratory equipment, training of starters and students in the use of core equipment such as ultra-centrifuges, as well as managing booking systems and cleaning rotas for Tissue Culture Labs and other core areas. You will assist with calculating the cost recovery charges to the Research Groups for many of the core facilities. Line Management of the Assistant Coordinator may also form part of the role, depending on your previous experience.

For appointments at Grade 6, the successful applicant will be qualified to HNC level in Biological Sciences or equivalent and have substantial experience in a research laboratory environment. You will have used a wide range of laboratory equipment and have experience of purchasing consumables and lab management. Experience and understanding of laboratory safety guidelines are a requirement, with significant knowledge of Biological and GM Safety highly desirable. The role will usually be appointed as the Biological Safety Officer for CIMR.

CIMR actively seek to develop and train staff for their future and has had significant success in meeting this aim. To this end, less experienced applicants with similar qualifications and identifiable potential for development are encouraged. The appointment in this case is likely to be made initially at a lower grade (Grade 5) with the prospect of promotion to Grade 6 once full performance of duties is achieved.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Flexible working is available, but with a minimum requirement of 80% FTE.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to Dave Cheesman, Lab & Facilities Manager, on djc69@cam.ac.uk

If you have any queries regarding the application process, please contact Charlotte Yelton, HR Supervisor, on caay2@cam.ac.uk

Please quote reference SA34645 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Buss lab at the Cambridge Institute for Medical Research is looking to recruit a Research Assistant, funded by the Medical Research Council, to study the kinetic properties and functional specialization of myosin motor proteins in Plasmodium falciparum parasites. The work of the Buss lab aims to establish how different classes of myosin motors are regulated and have fine-tuned their motor mechanics to full-fill their specialised cellular functions.

Applicants must hold an undergraduate degree in Biochemistry or Molecular Biology. Experience in culturing and phenotyping Plasmodium falciparum parasites is absolutely essential and further knowledge of the biochemical characterisation of P. falciparum proteins is highly desirable. A keen interest in molecular motors and the use of biophysical approaches to characterize motor properties is also desirable.

You must be highly collaborative and team-oriented in your approach to research. Good written and oral communication skills are expected.

Research will be carried out at the Cambridge Institute for Medical Research (CIMR), an interdisciplinary research institute within the University of Cambridge with a mission to explore the molecular mechanisms of human diseases in order to develop targeted therapeutic strategies. With outstanding core facilities and a dynamic and highly interactive group of research groups, CIMR https://www.cimr.cam.ac.uk is part of the School of Clinical Medicine and is based on the Cambridge Biomedical Campus. We are committed to diversity, inclusion and anti-racism, and applicants from groups that are under-represented in scientific research are particularly encouraged to apply

Fixed-term: The funds for this post are available for 12 months from 1 March 2023 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal queries should be directed to Professor Folma Buss by email fb207@cam.ac.uk .

Please quote reference SG34749 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.