CIMR vacancies on www.jobs.cam.ac.uk

The ALBORADA Drug Discovery Institute (ADDI), part of the University of Cambridge Institute for Medical Research (CIMR) (http://cambridge-ddi.alzheimersresearchuk.org/), is seeking a Research Associate with a strong background in biochemistry and/or biophysics to join its established team. The ADDI is part of a network of world-class Drug Discovery Institutes, funded by Alzheimer's Research UK, forming the Alzheimer's Research UK Drug Discovery Alliance. The work of the ADDI at Cambridge is aimed at validating new drug targets and identifying potential new drugs for the treatment of Alzheimer's disease as well as other types of neurodegeneration.

The ideal candidate will have demonstrable experience in assay development and the mechanistic validation of biological targets. Using biochemical and/or biophysical techniques, you will be responsible for designing and conducting studies to validate the link between putative targets and relevant disease mechanisms, as well as to characterise and assess compounds emerging from our drug discovery pipeline. You will collaborate closely with colleagues in the cell molecular biology and the in vivo teams, and work alongside medicinal and computational chemists to progress projects from target validation through to in vivo proof-of-concept models.

We are looking for someone with an enthusiastic and proactive mindset, strong troubleshooting skills, and an aptitude for data analysis. Applicants will be expected to be organised, self-motivated, flexible when required, eager to identify and implement improvements to protocols and study design, and to be a team player. Time-management and record-keeping skills, and interpersonal and communication skills are also expected. In addition to potentially supervising junior staff, you will contribute intellectually to the research program of the ADDI. This is an exciting opportunity to join a cutting-edge drug discovery team focused on tackling diseases that cause dementia and other neurodegenerative conditions.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Fixed-term: The funds for this post are available until 30 April 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is:25th August 2024

The interview date for the role is: To be confirmed

Please quote reference SA42528 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Internal Candidates Only

Applications are invited for an enthusiastic, committed and experienced post-doctoral researcher to complete functional and structural work on a pre-existing project investigating endosomal trafficking in the Owen lab of the Cambridge Institute for Medical Research.

As this is a short-term role to finish a project, it is essential that the successful applicant is available immediately.

As well as holding a PhD in a relevant discipline, you must have practical experience in Glut1-based trafficking assays and also have a wide range of molecular and cell biology techniques including stable transfection using retroviral systems, transient transfection, siRNA and CRISPR, immunoblotting, and confocal live/fixed cell imaging experience. A further key requisite is to have extensive biochemical experience with immunoprecipitation and pulldowns. An in-depth knowledge of lysosomal and endosomal biology and function would be extremely advantageous and a knowledge of endosomal organelle homeostasis would also be helpful. The ability to analyse fluorescent microscopy data by writing CellProfiler pipelines and the use of R and GraphPad Prism for statistical analysis is desirable.

In addition, applicants will be expected to have good written and verbal communication skills, to be well-organised and have the ability to work calmly to meet deadlines.

This is a fixed-term role with a limit of tenure of 30th November 2025.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic with a mission to determine the molecular mechanisms of disease in order to advance human health.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 1st August 2024

The interview date for the role is: Mid-August - To be confirmed

Please quote reference SG42529 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The ALBORADA Drug Discovery Institute (ADDI), part of the University of Cambridge Institute for Medical Research (CIMR) (http://cambridge-ddi.alzheimersresearchuk.org/), is seeking a Research Assistant or Research Associate with a background in animal research and tissue processing to join its established team. The ADDI is part of a network of world-class Drug Discovery Institutes, funded by Alzheimer's Research UK, forming the Alzheimer's Research UK Drug Discovery Alliance. The work of the ADDI at Cambridge is aimed at validating new drug targets and identifying potential new drugs for the treatment of Alzheimer's disease as well as other types of neurodegeneration.

The successful candidate will join our team to carry out animal research in a drug discovery environment. They will receive training and support to perform hands-on experiments with live animals and tissue samples from animal studies, as well as to provide broader technical support to the in vivo biology team. This is an exciting opportunity to join a cutting-edge drug discovery team focusing on the diseases that cause dementia and other neurodegenerative conditions, and to develop a range of valuable laboratory techniques. You will be expected to have experience in working within a laboratory-based environment, particularly working with animals. You will work closely with other biologists in the team, thereby making an instrumental contribution towards the project pipeline of the ADDI.

A successful Research Assistant candidate will hold a BSc or equivalent in a Life Science or related subject. Priority will be given to applicants with prior roles in animal research, including animal facility technicians and other roles involving mouse husbandry work. Research Associate appointments require a PhD or imminent completion of a PhD with relevant experience.

Key responsibilities:

• This is a full-time laboratory-based role. You will be responsible for executing in vivo experiments, such as dosing, stereotactic intracranial injections, general health observations, and tissue dissections.
• Support other laboratory-based colleagues in the in vivo group forming part of a safe, collaborative and well-organized laboratory environment.
  
• Help the team with ex vivo tissue processing, including tissue homogenization, protein and/or RNA extraction, tissue embedding, sectioning. Possibility to perform biochemical and histology experiments, such as Western blot and immunohistochemistry.
  
• Ability to be flexible and enjoy switching between a variety of techniques, both in vivo and ex vivo. Desire to develop new skills is encouraged.
  
• Contribute to data analysis using image analysis software (ImageJ, ImageLab) and statistics software (GraphPad Prism, InVivoStat).

Requirements

A BSc, or equivalent experience, in cell biology or mammalian biology, mouse husbandry or animal welfare.

• Willingness to undertake hands-on in vivo work in a predominantly laboratory-based role.
• Experience with animal research, including hands-on work with mice. Experience with mouse surgical techniques desirable, but not required.
• Home Office PIL holder strongly preferred, but not required. Willingness to obtain PIL qualification necessary.
• Desire to learn new techniques and expand proficiency in animal work procedures.
• Integrity and ethical standards associated with animal experimentation.
• Prior experience with tissue processing for histology (tissue embedding, sectioning, staining) desired, but not required.
• Exposure to biochemical laboratory techniques an advantage.
• Attention to detail, excellent communication and organization skills and diligent record keeping.
• Neuroscience or neurodegeneration experience an advantage.
  

Fixed-term: The funds for this post are available until 30 April 2026 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 25th August 2024

The interview date for the role is: To be confirmed

Please quote reference SA42527 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and skilled Post-doctoral Researcher to join the Nixon-Abell Laboratory at the Cambridge Institute for Medical Research. Our work sits at the interface between cell biology and molecular neuroscience. We employ integrated experimental approaches, combining cutting-edge microscopy, biochemistry, omics, and iPSC-derived cell models to understand organelle interactions and dynamics in neurons.

This Wellcome Trust funded project aims to draw fundamental links between organellar communication pathways and neuronal function. Specifically, the post-holder will focus on understanding how sites of direct physical interaction between organelles (membrane contact sites) coordinate the intracellular distribution of lipids in neurons. The candidate will form part of a vibrant and interdisciplinary team focussed on producing rigorous, innovative, and impactful research. This role will also offer various career development opportunities to support the candidate's professional progression.

All applicants must hold (or imminently be receiving) a PhD in a relevant field and have research experience in mechanistic cell biology. Prior post-doctoral research experience is highly desirable. A background in membrane contact sites would be advantageous and technical experience in one or more of the following, highly beneficial: endomembrane biology assays, lipidomics/metaboolomics/proteomics, electrophysiology. Previous experience working with lipids is preferable, although not required.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

The successful applicant will be expected to work independently and collaboratively as part of a diverse team. This full-time fixed-term post is funded by the Wellcome Trust for 3 years in the first instance. This position is graded on the University's Grade 7 scale, for which the salary range is £36,024 - £44,263 per annum. The starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

For informal enquiries please contact Dr Jonathon Nixon-Abell (jjn36@cam.ac.uk).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 22nd July 2024

The interview date for the role is: Mid August 2024

Please quote reference SD42428 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and skilled Post-doctoral Researcher to join the Nixon-Abell Laboratory at the Cambridge Institute for Medical Research. Our work sits at the interface between cell biology and molecular neuroscience. We employ integrated experimental approaches, combining cutting-edge microscopy, biochemistry, omics, and iPSC-derived cell models to understand organelle interactions and dynamics in neurons.

This Wellcome Trust funded project aims to draw fundamental links between organellar communication pathways and neuronal function. Specifically, the post-holder will focus on understanding how sites of direct physical interaction between organelles (membrane contact sites) coordinate the intracellular distribution of lipids in neurons. The candidate will form part of a vibrant and interdisciplinary team focussed on producing rigorous, innovative, and impactful research. This role will also offer various career development opportunities to support the candidate's professional progression.

All applicants must hold (or imminently be receiving) a PhD in a relevant field and have research experience in mechanistic cell biology. Prior post-doctoral research experience is highly desirable. A background in membrane contact sites would be advantageous and technical experience in one or more of the following, highly beneficial: endomembrane biology assays, lipidomics/metaboolomics/proteomics, electrophysiology. Previous experience working with lipids is preferable, although not required.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

The successful applicant will be expected to work independently and collaboratively as part of a diverse team. This full-time fixed-term post is funded by the Wellcome Trust for 3 years in the first instance. This position is graded on the University's Grade 7 scale, for which the salary range is £36,024 - £44,263 per annum. The starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

For informal enquiries please contact Dr Jonathon Nixon-Abell (jjn36@cam.ac.uk).

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SD40768 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Cambridge Institute for Medical Research (CIMR) is seeking to recruit an outstanding individual to make a significant contribution to the strategy, communication and future of the Institute. CIMR is an interdisciplinary biomedical research institute, part of the University Cambridge Clinical School and sited on the Cambridge Biomedical Campus. It has a strong track record of delivering cutting edge medical cell biology research, and celebrated its 20th anniversary.

The post holder will work with the Director of the CIMR focusing particularly on the development and delivery of CIMR strategy, communication, governance, evaluation and funding. They will work closely with the CIMR Administrator, PA to the Director and other members of the administration team to provide joined-up strategic, operational and administrative support to the Director and Institute.

The successful candidate will have undergraduate training relevant to cell biology or medicine, and extensive experience in scientific strategic management. They will have excellent writing and communication skills, as well as strong interpersonal skills in listening, team working and consensus building. They will be independent, motivated, and committed to the long-term success of CIMR.

The full incremental salary range for the position is advertised in order to demonstrate the progression of the Grade. In the majority of case appointments will be made at the Grade minimum, although appointments at a higher salary can be offered to the right candidate.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative Institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

The position is supported for 3 years initially, with the expectation that further funding will be sought to extend the position to be a long-term feature of the Institute.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 1st August 2024

The interview date for the role is: 8th August 2024

Please quote reference SA42391 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We have an opportunity for a postdoctoral Research Associate to join our team studying new mechanisms driving neurodegenerative diseases. This is a Wellcome Trust-funded post in the laboratory of Dr Janet Deane at the Cambridge Institute for Medical Research. Our lab uses a wide range of techniques to study how altered lipid metabolism drives changes in the cellular proteome causing neuronal pathologies. We are looking for a postdoctoral researcher with experience in cell biology with a keen interest in translating cell-based discoveries into molecular insights.

The post holder must possess a PhD in Biochemistry, Cell Biology, Neuroscience or a relevant subject and have a good track record of generating high-quality data for publications. They must have good interpersonal skills as well as the ability to communicate their work clearly in both formal and informal settings. The candidate must have great attention to detail and excellent record keeping. Experience training postgraduate students in laboratory techniques would be advantageous.

We are looking for an enthusiastic scientist with experience in cell biology including complex cultures such as iPSCs or organoids, ideally with brain cell types including neurons, microglia and/or astrocytes. Experience with cell-based models of late-onset neurodegenerative diseases would be advantageous. To excel in this role, an appreciation of the importance of both lipids and proteins for cell adhesion and membrane trafficking is highly advantageous.

The successful applicant will be part of a team with established expertise in protein biochemistry including protein-protein and protein-lipid interaction assays and structural biology. We also have extensive experience in the generation of cell-based models of disease including using CRISPRi in iPSC cells as well as phenotypic characterisation of these models using proteomics and fluorescence microscopy. Due to the supportive nature of the laboratory, enthusiastic candidates will have the opportunity to learn techniques that expand their research skills. Furthermore, we encourage creative thinking when tackling scientific problems and are keen for lab members to adopt new technologies and approaches when appropriate.

Fixed-term: The funds for this post are available until April 2026 in the first instance.

For informal enquiries please contact Dr Janet Deane at jed55@cam.ac.uk

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £31,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SD42104 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Working with organoid models to understand mechanisms in familial interstitial lung disease

Dr Dickens and the Marciniak Group are seeking a postdoctoral fellow to drive innovation in a programme of research investigating triggers of alveolar epithelial dysfunction in familial forms of interstitial lung disease. You will work with novel alveolar organoids, creating patient-specific models which you will interrogate using innovative culture techniques, genetic manipulation and multi-omics analysis including proteomics and transcriptomics with a view to identifying novel therapeutic targets.

You should have a track record in wet-lab cell biology and possess a PhD in a relevant discipline. Prior experience of working with organoids and/or in respiratory disease research would be an advantage, but training will be provided.

The successful applicant will join Dr Dickens, a clinician scientist, and a diverse team of basic and translational scientists and clinicians within the Marciniak Group. We are committed to promoting an exciting, rewarding and healthy working environment and strive to support the career goals of our team members.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Fixed-term: The post will run for 3 years in the first instance.

Recent relevant papers

Lim K, Rutherford EN, Sun D, Van den Boomen DJH, Edgar JR, Bang J, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. BioRxiv (https://doi.org/10.1101/2023.08.30.555522)

Dickens JA, Rutherford EN, Abreu S, Chambers JE, Ellis MO, van Schadewijk A, Hiemstra P, Marciniak SJ. Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant. Eur Respir J 2022;59:2100267

Please contact Dr Jenny Dickens at jac72@cam.ac.uk for further information.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SC42003 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner Laboratory at the Cambridge Institute for Medical Research is recruiting a Research Associate to develop and apply a microfluidic device to study the invasion of human red blood cells by Plasmodium parasites. You will fabricate and test different device designs using soft lithography, load them with Plasmodium infected red blood cells, and use video microscopy to follow uninfected and infected red blood cells as they traverse through the microfluidic channels. You will then use tracking software to monitor the speed and behaviour of different cell types as they move through the channels, and will feed into the design and development of this custom software. This is a complex project involving skills in both biophysics and parasite biology, with very short delivery timelines.

The successful candidate therefore must have extensive hands-on experience in all the core techniques - designing, making and testing microfluidic devices using soft lithography, culturing Plasmodium parasites specifically in the UK regulatory environment, ie under derogated CL3 conditions, and analysing video microscopy data visually and computationally. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement.

You will work as part of a vibrant interdisciplinary team and in close collaboration with partners and colleagues in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed, and you will present your work at both internal and external academic events.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

The role is fixed term from 1st August 2024 - 30th November 2024.

Fixed-term: The funds for this post are available until 30 November 2024 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £31,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SG41970 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Working with organoid models to understand mechanisms in familial interstitial lung disease

Dr Dickens and the Marciniak Group are seeking a postdoctoral fellow to drive innovation in a programme of research investigating triggers of alveolar epithelial dysfunction in familial forms of interstitial lung disease. You will work with novel alveolar organoids, creating patient-specific models which you will interrogate using innovative culture techniques, genetic manipulation and multi-omics analysis including proteomics and transcriptomics with a view to identifying novel therapeutic targets.

You should have a track record in wet-lab cell biology and possess a PhD in a relevant discipline. Prior experience of working with organoids and/or in respiratory disease research would be an advantage, but training will be provided.

The successful applicant will join Dr Dickens, a clinician scientist, and a diverse team of basic and translational scientists and clinicians within the Marciniak Group. We are committed to promoting an exciting, rewarding and healthy working environment and strive to support the career goals of our team members.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Fixed-term: The post will run for 3 years in the first instance.

Recent relevant papers

Lim K, Rutherford EN, Sun D, Van den Boomen DJH, Edgar JR, Bang J, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. BioRxiv (https://doi.org/10.1101/2023.08.30.555522)

Dickens JA, Rutherford EN, Abreu S, Chambers JE, Ellis MO, van Schadewijk A, Hiemstra P, Marciniak SJ. Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant. Eur Respir J 2022;59:2100267

Please contact Dr Jenny Dickens at jac72@cam.ac.uk for further information.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SC42003 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner Laboratory at the Cambridge Institute for Medical Research is recruiting a Research Associate to work on a project that combines Plasmodium knowlesi parasite culture and experimental genetics to perform systematic screens to understand malaria gene function. Focusing on antimalarial drug resistance and mechanisms of action, you will perform large-scale random mutagenesis screens using piggyBac transposons and select for specific phenotypes using drug pressure or novel phenotyping platforms. As the project is already underway and has a short delivery timeline, we are looking for someone with extensive experience in the relevant techniques.

To hit the ground running, the successful candidate will need multiple years of experience specifically in culturing and transfecting Plasmodium knowlesi parasites using both random and targeted genetic approaches, in performing phenotyping and screening assays with Plasmodium knowlesi parasites, and in analysing and interpreting sequencing-related outputs from large-scale genetic screens. You will also have working knowledge of UK biosafety regulations and restrictions in order to allow you to work immediately in the CL3 malaria parasite culture laboratory. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement.

You will work as part of a vibrant interdisciplinary team and in close collaboration with partners and colleagues in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed, and you will present your work at both internal and external academic events.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Fixed-term: The funds for this post are available until 30 June 2026 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Fixed-term: The funds for this post are available until 30 June 2026 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Please quote reference SG41964 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner Laboratory at the Cambridge Institute for Medical Research is recruiting a Research Associate to develop and apply a microfluidic device to study the invasion of human red blood cells by Plasmodium parasites. You will fabricate and test different device designs using soft lithography, load them with Plasmodium infected red blood cells, and use video microscopy to follow uninfected and infected red blood cells as they traverse through the microfluidic channels. You will then use tracking software to monitor the speed and behaviour of different cell types as they move through the channels, and will feed into the design and development of this custom software. This is a complex project involving skills in both biophysics and parasite biology, with very short delivery timelines.

The successful candidate therefore must have extensive hands-on experience in all the core techniques - designing, making and testing microfluidic devices using soft lithography, culturing Plasmodium parasites specifically in the UK regulatory environment, ie under derogated CL3 conditions, and analysing video microscopy data visually and computationally. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement.

You will work as part of a vibrant interdisciplinary team and in close collaboration with partners and colleagues in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed, and you will present your work at both internal and external academic events.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

The role is fixed term from 1st August 2024 - 30th November 2024.

Fixed-term: The funds for this post are available until 30 November 2024 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SG41970 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner Laboratory at the Cambridge Institute for Medical Research is recruiting a Research Associate to work on a project that combines Plasmodium knowlesi parasite culture and experimental genetics to perform systematic screens to understand malaria gene function. Focusing on antimalarial drug resistance and mechanisms of action, you will perform large-scale random mutagenesis screens using piggyBac transposons and select for specific phenotypes using drug pressure or novel phenotyping platforms. As the project is already underway and has a short delivery timeline, we are looking for someone with extensive experience in the relevant techniques.

To hit the ground running, the successful candidate will need multiple years of experience specifically in culturing and transfecting Plasmodium knowlesi parasites using both random and targeted genetic approaches, in performing phenotyping and screening assays with Plasmodium knowlesi parasites, and in analysing and interpreting sequencing-related outputs from large-scale genetic screens. You will also have working knowledge of UK biosafety regulations and restrictions in order to allow you to work immediately in the CL3 malaria parasite culture laboratory. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement.

You will work as part of a vibrant interdisciplinary team and in close collaboration with partners and colleagues in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed, and you will present your work at both internal and external academic events.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Fixed-term: The funds for this post are available until 30 June 2026 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £31,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SG41964 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking to recruit an energetic and well organised person to manage a busy Wellcome Trust funded laboratory and facilitate ongoing research projects within the group. The research group is part of the Cambridge Institute for Medical Research on the Cambridge Biomedical Campus. The laboratory works on the molecular mechanisms that control killing by cytotoxic T lymphocytes - important cells of the immune system that kill virally infected and cancer cells. Our research combines cell biology and immunology, using genetic approaches including CRISPR and single cell RNA sequencing of primary lymphocytes, together with high-resolution imaging.

The holder of the post will play a key role in the smooth running of the laboratory, particularly managing the organisation of the laboratory, responsibility for databases, ordering, orientating new staff, working with students (undergraduate and postgraduate) and supporting research projects in the laboratory as necessary.

The applicant must be a graduate in a scientific subject and several years' experience working within a biological laboratory environment would be preferable. We are seeking someone who will be able to oversee the general running of the laboratory and facilitate the work of the scientists within it. This will involve assisting with experiments, but also ensuring that the laboratory runs smoothly day-to-day. There is flexibility within this role that could be possible for applicants with experience requiring part-time working.

Core tasks will include but would not be limited to:

• Assisting with experiments (eg molecular biology, cell culture, flow cytometry).
• Placing orders and liaising with company representatives to negotiate prices.
• Maintenance and cataloguing of laboratory stocks (eg plasmids and cell lines).
• Keeping task assessments up to date.
• Management of laboratory equipment.

This position is graded on the University's Grade 5 scale, for which the salary range is £29,605 - £33,966 per annum. The start salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic with a mission to determine the molecular mechanisms of disease in order to advance human health.

For informal enquiries please contact Professor Gillian Griffiths (gg305@cam.ac.uk).

Fixed-term: The funds for this post are available until 30 June 2025 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 20th June 2024

The interview date for the role is: 10th July 2024

Please quote reference SC41829 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking to recruit an energetic and well organised person to manage a busy Wellcome Trust funded laboratory and facilitate ongoing research projects within the group. The research group is part of the Cambridge Institute for Medical Research on the Cambridge Biomedical Campus. The laboratory works on the molecular mechanisms that control killing by cytotoxic T lymphocytes - important cells of the immune system that kill virally infected and cancer cells. Our research combines cell biology and immunology, using genetic approaches including CRISPR and single cell RNA sequencing of primary lymphocytes, together with high-resolution imaging.

The holder of the post will play a key role in the smooth running of the laboratory, particularly managing the organisation of the laboratory, responsibility for databases, ordering, orientating new staff, working with students (undergraduate and postgraduate) and supporting research projects in the laboratory as necessary.

The applicant must be a graduate in a scientific subject and several years' experience working within a biological laboratory environment would be preferable. We are seeking someone who will be able to oversee the general running of the laboratory and facilitate the work of the scientists within it. This will involve assisting with experiments, but also ensuring that the laboratory runs smoothly day-to-day. There is flexibility within this role that could be possible for applicants with experience requiring part-time working.

Core tasks will include but would not be limited to:

• Assisting with experiments (eg molecular biology, cell culture, flow cytometry).
• Placing orders and liaising with company representatives to negotiate prices.
• Maintenance and cataloguing of laboratory stocks (eg plasmids and cell lines).
• Keeping task assessments up to date.
• Management of laboratory equipment.

This position is graded on the University's Grade 5 scale, for which the salary range is £29,605 - £33,966 per annum. The start salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic with a mission to determine the molecular mechanisms of disease in order to advance human health.

For informal enquiries please contact Professor Gillian Griffiths (gg305@cam.ac.uk).

Fixed-term: The funds for this post are available until 30 June 2025 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 20th June 2024

The interview date for the role is: 10th July 2024

Please quote reference SC41829 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and skilled Post-doctoral Research Associate to join the Nixon-Abell laboratory at the Cambridge Institute for Medical Research. Our work sits at the interface between cell biology and molecular neuroscience. We employ integrated experimental approaches, combining cutting-edge microscopy, biochemistry, omics, and iPSC-derived cell models to understand organelle interactions and dynamics in neurons.

This Wellcome Trust funded project aims to draw fundamental links between organellar communication pathways and neuronal activity. Specifically, the post-holder will focus on developing a CRISPR-based screen to understand the contribution of intra-organellar communication machinery in neuronal transmission. The candidate will form part of a vibrant and interdisciplinary team focussed on producing rigorous, innovative, and impactful research.

All applicants must hold a PhD in a relevant field and have significant research experience in culturing iPSC-derived neurons and/or CRISPR screening. Prior post-doctoral research experience is highly desirable. The successful applicant will be expected to work independently and collaboratively as part of a diverse team, with this project supported by a Research Assistant who the post-holder will work closely with and help supervise on a day-to-day basis.

This full-time fixed-term post is funded by the Wellcome Trust for up to one year. This position is graded on the University's Grade 7 scale, for which the salary range is £36,024-£44,263 per annum. The starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available. The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative Institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

For informal enquiries please contact Dr Jonathon Nixon-Abell (jjn36@cam.ac.uk).

Fixed-term: The funds for this post are available for 1 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 6th June 2024

The interview date for the role is: Mid June 2024

Please quote reference SD41828 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and committed Research Assistant to join our laboratory in the Cambridge Institute for Medical Research (CIMR) to study the genetic basis of pulmonary vascular disease using mouse and cell models. Applicants must have laboratory experience and a degree in biological science. Prior animal experience would be advantageous, though training will be provided. There is the potential to pursue a research degree (MPhil) during this project.

Mutations in GCN2 cause a rare but progressive and ultimately fatal form of pulmonary hypertension called pulmonary veno-occlusive disease. There is currently no licenced drug treatment for this. We are seeking to understand how loss of GCN2 causes pulmonary vascular disease and have developed 2 mouse models in the first instance to dissect out mechanisms of disease.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Relevant papers: Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension. (2015) Soon E, Crosby A, Southwood M, et al. Am J Respir Crit Care Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC.

The integrated stress response in pulmonary disease. (2020) Emanuelli G, Nassehzadeh-Tabriz N, Morrell NW, Marciniak SJ. Eur Respir Rev. 2020 Oct 1;29(157):200184. doi: 10.1183/16000617.0184-2020.

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension. (2024) Emanuelli G, Zhu J, Morell NW, Marciniak SJ (2024). bioRxiv. 2024 Jan 30. https://doi.org/10.1101/2024.01.27.577559.

Please contact Professor Stefan Marciniak (sjm20@cam.ac.uk) or Elaine Soon (eels2@cam.ac.uk) for further information.

Fixed-term: The funds for this post are available for 1 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SC41596 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and committed Research Assistant to join our laboratory in the Cambridge Institute for Medical Research (CIMR) to study the genetic basis of pulmonary vascular disease using mouse and cell models. Applicants must have laboratory experience and a degree in biological science. Prior animal experience would be advantageous, though training will be provided. There is the potential to pursue a research degree (MPhil) during this project.

Mutations in GCN2 cause a rare but progressive and ultimately fatal form of pulmonary hypertension called pulmonary veno-occlusive disease. There is currently no licenced drug treatment for this. We are seeking to understand how loss of GCN2 causes pulmonary vascular disease and have developed 2 mouse models in the first instance to dissect out mechanisms of disease.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Relevant papers: Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension. (2015) Soon E, Crosby A, Southwood M, et al. Am J Respir Crit Care Med. 2015 Oct 1;192(7):859-72. doi: 10.1164/rccm.201408-1509OC.

The integrated stress response in pulmonary disease. (2020) Emanuelli G, Nassehzadeh-Tabriz N, Morrell NW, Marciniak SJ. Eur Respir Rev. 2020 Oct 1;29(157):200184. doi: 10.1183/16000617.0184-2020.

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension. (2024) Emanuelli G, Zhu J, Morell NW, Marciniak SJ (2024). bioRxiv. 2024 Jan 30. https://doi.org/10.1101/2024.01.27.577559.

Please contact Professor Stefan Marciniak (sjm20@cam.ac.uk) or Elaine Soon (eels2@cam.ac.uk) for further information.

Fixed-term: The funds for this post are available for 1 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SC41596 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a Research Associate to study the molecular details of IRE1 activation and complete a research project previously initiated in the laboratory.

You will join a team led by Professor David Ron studying protein folding homeostasis in the Endoplasmic Reticulum. You will be primarily responsible for application of molecular and cellular biology tools to explore the mechanisms of IRE1 activation. You are expected to lead this project drawing on the advances previously made and described in PMID: 31873072, 38177498, 38177501.

Duties include but are not limited to: Design and creation of genetically modified cells using CRISPR/Cas9 gene editing to test specific hypothesis on the basis of IRE1 activation. Design and execution of complex multi-channel FACS experiments exploiting the cells described above. Design, expression and purification of bacterial-expressed proteins used in the study of IRE1 regulation in vitro. Implementing biophysical techniques used to study IRE1 regulation in vitro: analytical size exclusion chromatography by HPLC, Mass photometry, Analytical Ultracentrifugation, Fluorescence resonance energy transfer (FRET), Bioluminescence resonance energy transfer (BRET), Fluorescent polarisation and biolayer interferometry (BLI). Applicants should have PhD or equivalent degree in Biomedical Science, Biochemistry, Genetics or a related discipline.

Requirements are:

A proven track record of success in applying multidimensional FACS analysis, molecular biology and protein chemistry techniques to the study of protein folding homeostasis in the Endoplasmic Reticulum.

A proven track record of success in design, creation and genetic and phenotypic validation of multiple modified cell lines using CRISPR/Cas9 in the study of protein folding homeostasis in the Endoplasmic Reticulum.

A proven track record of success in applying biophysical techniques of Analytical SEC, Mass photometry, AUC, FRET, BRET and FP to the study of the unfolded protein response.

Good communication, team-work, organisational and record keeping skills are essential.

Preference will be given to applicants with familiarity with the laboratory's knock-in system for studying IRE1 chimeras and a track-record of publication in the area of IRE1 activation.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Please contact Professor David Ron at dr360@cam.ac.uk for further information

Fixed-term: The funds for this post are available until 30 June 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager

Please quote reference SG41526 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work on a project that explores the function of a multi-gene family that is expanded in the genomes of Plasmodium Vivax and other related neglected human malaria parasites. The project builds on a recent publication that established that these tryptophan-rich antigens (TRAgs) have lipid binding activity (PMID: 37709739). It will expand on these initial findings using CRISPR/Cas9 genetic modification to knockout and tag multiple TRAg genes in Plasmodium Knowlesi and explore their function using a range of cell biological and biochemical assays.

To hit the ground running the successful candidate will need hands-on and demonstrable experience in culturing and transfecting Plasmodium parasites, preferably specifically Plasmodium Knowlesi. You will also have extensive experience in using molecular biology techniques (e.g. Gibson Assembly) to generate and validate complex genetic manipulation vectors, as well as in relevant cell biology techniques such as advanced microscopy and flow cytometry. There is also the potential to be involved in more biochemical focussed work, including recombinant protein expression and crystallography, if that is of interest. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement. You will work as part of a vibrant interdisciplinary team and in close collaboration with colleagues in both the Rayner and Deane Laboratories in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed, and you will present your work regularly at both internal and external academic events. The role has the potential to be a key stepping stone in a research career and multiple career development and support opportunities are available.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £31,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SG41220 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.