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Cambridge Institute for Medical Research

 
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Updated: 24 min 33 sec ago

Head of Biology (Director of Research)

Wed, 29/06/2022 - 00:00

Head of Biology

The ALBORADA Drug Discovery Institute (ADDI) at the University of Cambridge is seeking an innovative, creative and experienced neuroscientist to lead and develop the institute's biology team and contribute to the vision and direction of this prestigious venture. The ADDI is a multidisciplinary group of biologists and chemists developing new therapies for neurodegenerative diseases. The biology group comprises cell and molecular neurobiologists, assay development and screening scientists and an in vivo biology team each supported by experienced team leaders and fully equipped laboratory space.

As Head of Biology you will be the most senior biologist in the ADDI team and will report to, and work in partnership with, the Chief Scientific Officer and along with the Head of Chemistry and Lead Academic Scientist, be a member of the institute's senior leadership team with the overall objective of establishing and delivering on projects, moving them towards the clinic through partnership with industry and growing the institute's research budget.

You will be responsible for the scientific output and development of the biology group and will have line-management responsibility for a portfolio of projects as well as staff and budgets. Through interaction with Prof Roger Barker, the institute's Lead Academic Scientist, you will help shape our developing clinical strategy and use of human data.

Scientifically, you will take a leading role in the identification and development of new targets and projects and will be encouraged to develop new concepts and approaches. The successful applicant may come from industry or academia, is expected to bring access to a network of potential collaborators and will be strongly encouraged to develop opportunities and new partnerships. You will be supported in raising further funding through grant applications or venture capital to develop projects and explore new hypotheses.

The successful applicant will have a PhD and relevant translational research and leadership expertise. You are expected to have an excellent understanding of mechanisms underpinning neurodegenerative disease and a good appreciation of the importance of omics and human data to target identification.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 15th August 2022

First stage interviews will take place: w/c 5th September, although this could be subject to change.

For an informal discussion in confidence please contact our recruitment partner Roger Russell at Penna on 07710 701 570 or email roger.russell@penna.com

Applications, consisting of a letter of application, a statement of current and future research plans, a curriculum vitae, and a publications list, along with details of three referees should be submitted online via the University Cambridge jobs page www.jobs.cam.ac.uk by clicking 'Apply online' in the job advert.

Please quote reference SA31994 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

Thu, 14/04/2022 - 00:00

The ALBORADA Drug Discovery Institute (ADDI), part of the University of Cambridge CIMR Division of Translational Medicine (http://cambridge-ddi.alzheimersresearchuk.org/), is seeking a biologist with a background in neurodegeneration. The ADDI is part of a network of world-class Drug Discovery Institutes, funded by Alzheimer's Research UK, forming the Alzheimer's Research UK Drug Discovery Alliance. The work of the ADDI is aimed at validating new drug targets and identifying potential new drugs for the treatment of Alzheimer's disease as well as other forms of neurodegeneration.

The successful candidate will be a member of our Cell and Molecular Biology Team and will be responsible for designing and performing studies to validate the link between targets and disease and for carrying out studies to characterise and assess compounds emerging from our drug discovery programmes. Within the role there will also be opportunities to contribute to target identification and to in vivo studies in rodents. This demands an enthusiastic and proactive mindset, along with a demonstrable ability to troubleshoot and optimise methods and an aptitude for data analysis.

The successful candidate will be required to have the following skills and experience:

  • A PhD in Biology with laboratory-based experience, or over 5 years of experience in a relevant research environment.
  • Experience in neurodegenerative disease research.
  • Practical experience with optimising and troubleshooting immunostaining and basic molecular biology techniques.
  • Familiarity with cell-based assays and culture techniques.
  • A willingness to provide scientific leadership and potentially supervise junior staff.

Additional desirable attributes would be:

  • Knowledge of handling large data-sets from image analysis and data analysis software.
  • Practical experience in bioinformatics.
  • Knowledge of high-content and high-throughput automation platforms.
  • Experience with the drug discovery process.

Working with chemists and other biologists in a stimulating and collaborative environment with opportunities for training and development, the successful candidate will also be encouraged to contribute to implementing new technologies and processes.

Specific enquiries about the post may be addressed to Dr. John Skidmore (js930@cam.ac.uk).

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Fixed-term: The funds for this post are available until 30 April 2024 in the first instance.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date for all applications is Sunday 15th May 2022 with interviews to be confirmed at a later date.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

Please quote reference SA30968 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Level Coordinator/Chief Research Laboratory Technician

Thu, 14/04/2022 - 00:00

An exciting opportunity has arisen for a coordinator of laboratory services to join the CIMR Laboratory Management Team. This role is ideal for someone looking to develop his or her career in laboratory management.

Along with an Assistant, you will provide support and assistance for the communal laboratory facilities. These include Tissue Culture labs, Containment Level 2/Blood Handling labs, Radioactive Tissue Culture, Core Equipment rooms (including centrifuges, spectrometers, orbital incubators, PCR machines, gel documentation systems etc.), cold rooms and dark rooms.

You will also be responsible for negotiating discounts on consumables, arranging maintenance and repairs of laboratory equipment, training of starters and students in the use of core equipment such as ultra-centrifuges, as well as managing booking systems and cleaning rotas for Tissue Culture Labs and other core areas. You will calculate the cost recovery charges to the Research Groups for many of the core facilities. Line management of the Assistant Coordinator may also form part of the role, depending on your previous experience.

For appointments at Grade 6, the successful applicant will be qualified to HNC level in Biological Sciences or equivalent and have substantial experience in a research laboratory environment. You will have used a wide range of laboratory equipment and have experience of purchasing consumables and lab management. Experience and understanding of laboratory safety guidelines are a requirement, with significant knowledge of Biological and GM Safety highly desirable. The role will usually be appointed as the Biological Safety Officer for CIMR.

CIMR actively seek to develop and train staff for their future and has had significant success in meeting this aim. To this end, less experienced applicants with similar qualifications and identifiable potential for development are encouraged. The appointment in this case is likely to be made initially at a lower grade (Grade 5) with the prospect of promotion to Grade 6 once full performance of duties is achieved. The salary range for a Grade 5 role is £27,116 - £31,406.

This role requires a Security Check and Occupational Health clearance. Any offer of employment we make to you will be conditional upon the satisfactory completion of these check(s); whether an outcome is satisfactory will be determined by the University.

The role is full-time, but flexible working is available with a minimum requirement of 80% FTE.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries about the role, contact: Dave Cheesman, Lab & Facilities Manager, email djc69@cam.ac.uk

For questions regarding the application process, contact: Charlotte Yelton, HR Supervisor, email caay2@cam.ac.uk

Please quote reference SA30858 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Michael House PhD Studentship (Fixed Term)

Thu, 31/03/2022 - 00:00

The Michael House PhD Studentship on the molecular mechanisms of rare, paediatric neurological disease

CIMR's mission is to determine the molecular mechanisms of disease in order to advance human health. Bringing together outstanding fundamental and clinical researchers, we focus on central pathways of cellular homeostasis and how they are disrupted in disease. We have a particular focus on rare genetic diseases; an area of great unmet clinical need.

A PhD studentship is available to start in October 2022 at CIMR. Supported by a generous philanthropic gift, the Studentship will focus on the molecular mechanisms of rare neurological diseases which affect children. Most of the 7,000 known rare diseases are genetic in origin, begin in childhood and have neurological symptoms ¿ often with devastating impact. In most cases, there are no effective treatments and an urgent need for new therapies.

Due to the growing power of whole genome sequencing (WGS), there is a significant increase in genetic diagnoses for early-onset genetic diseases. However, it is vital to move from genome sequence to molecular understanding using cellular or biochemical models and applying expertise in the particular biological pathways that are affected. The successfully-appointed Student will use a variety of such approaches to determine the functional impact of variants associated by WGS with rare paediatric neurological diseases. This will provide insights into the biology of the genes / proteins and disease in question and a basis for downstream translational research.

There are 3 different topics / supervisors for the successful candidate to select one from:

  1. A multidisciplinary strategy for understanding mechanisms of rare neurodegenerative diseases (Dr Janet Deane https://www.cimr.cam.ac.uk/staff/dr-janet-deane)

  2. The molecular pathological mechanisms of hereditary spastic paraplegias (Prof Evan Reid https://www.cimr.cam.ac.uk/staff/professor-evan-reid)

  3. Rare neurodevelopmental disorders of the mammalian secretory pathway (Dr David Gershlick https://www.cimr.cam.ac.uk/staff/dr-david-gershlick and Prof Evan Reid)

More information about the projects is found is on the application form: https://www.cimr.cam.ac.uk/file/mhstudentshipapplicationformdocx

This studentship is fully funded for a maximum of 3.5 years, with fees at the Home student rate and a starting annual stipend of £18,000.

To be eligible to apply, students must:

  1. Meet University of Cambridge 'Home student' admission requirements (details: https://www.postgraduate.study.cam.ac.uk/finance/fees/what-my-fee-status )

  2. Have, or are be expected to attain at least an upper second class honours degree in a relevant biological sciences subject

  3. Command English language skills that meet the minimum requirements https://www.postgraduate.study.cam.ac.uk/international/competence-english .

There is a two-step application process for this studentship: First, candidates must download and email a completed application form (https://www.cimr.cam.ac.uk/file/mhstudentshipapplicationformdocx ) and return it with a CV with names and contact details of 2 academic references to Amanda Goldsmith, phdadmin@cimr.cam.ac.uk, by 12:00 noon on Wednesday 20th April 2022. Shortlisted candidates will be invited to interview during the 1st week in May.

Following interview, the successful candidate will be invited to apply online to Postgraduate Admissions the University of Cambridge. They will receive information on how to do this at the time.

Fixed-term: The funds for this post are available for 3.5 years in the first instance.

For enquiries relating to the application process contact Amanda Goldsmith phdadmin@cimr.cam.ac.uk . For project enquiries contact relevant Supervisor.

Please quote reference SG30764 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society, particularly from groups who are historically under-represented in research.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Medicinal Chemistry Project Leader (Senior Research Associate) [Fixed Term]

Tue, 22/03/2022 - 00:00

*Appointment to Senior Research Associate is subject to approval by the Faculty Board of the Cambridge School of Clinical Medicine

The ALBORADA Drug Discovery Institute (ADDI) is seeking a talented Medicinal Chemistry Project Leader to join its team.

The ADDI is part of a network of world-class Drug Discovery Institutes funded by Alzheimer's Research UK and prosecutes drug discovery projects from target to in vivo proof of concept and beyond for novel targets in the neurodegeneration therapeutic area. This is an exciting opportunity to join this established Institute which is based on the prestigious Cambridge Biomedical Campus.

The successful applicant will have a PhD (or equivalent) in a relevant field and extensive experience of drug discovery. Reporting to the Head of Chemistry, they will be responsible for managing multidisciplinary drug discovery teams to meet project objectives. In particular, they will lead medicinal chemists to design and synthesize hits and leads for protein targets with therapeutic potential in neurodegeneration. This may include applying innovative approaches to hit identification as well as devising and implementing strategies to improve biological activity and reduce DMPK liabilities during lead generation and lead optimization. The applicant will have proven experience of working with biology colleagues and leaders to influence project strategy and successfully design cellular and in vivo experiments. The successful applicant will be active in the chemistry lab and have excellent medicinal and synthetic chemistry skills, a flair for problem solving and a history of leadership. They will likely have experience of managing line reports and/or external contractors. Moreover, they will have excellent communication, management and organisational skills, and a willingness to work as part of a team in order to drive forward collaborative projects.

Specific enquiries about the post may be addressed to Steve Andrews (spa26@cam.ac.uk).

Fixed-term: The funds for this post are available until 31 October 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing Date: 24th April 2022

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SA30609 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Research Associate (Fixed Term)

Tue, 15/03/2022 - 00:00

We have an exciting opportunity for a Research Associate to join our team studying the molecular mechanisms linking lysosomal dysfunction to neurodegenerative diseases. This is a Wellcome Trust-funded post in the laboratory of Dr Janet Deane at the Cambridge Institute for Medical Research. We encourage applications from scientists with a background in biochemistry and/or cell biology who have a keen interest in developing cell-based discoveries into molecular insights

The post holder must possess or are soon to be awarded a PhD in Biochemistry, Cell Biology or a relevant subject and have a proven track record of generating publication-quality data. The successful applicant will be part of a team with established expertise in protein expression and purification, protein-protein and protein-lipid interaction assays, structural biology and the generation of cell-based models of disease including CRISPRi in iPSC cells. We are looking for a candidate with experience that complements these skills and a desire to be part of a multidisciplinary team. Experience with membrane protein function or lipid biochemistry and an understanding of membrane trafficking would be advantageous. The candidate must have great attention to detail and excellent record keeping. They must also have good interpersonal skills as well as the ability to communicate their work clearly in both formal and informal settings. Due to the supportive nature of the laboratory enthusiastic candidates will have the opportunity to learn additional techniques and expand their research skills. Furthermore, we encourage creative thinking when tackling scientific problems and are keen for lab members to adopt new technologies and approaches when appropriate.

Fixed-term: The funds for this post are available until 14 April 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries please contact Dr Janet Deane at jed55@cam.ac.uk .

Interviews to be held in May.

Please quote reference SD30506 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Receptionist (Part Time)

Mon, 14/03/2022 - 00:00

The Keith Peters Building houses the Cambridge Institute for Medical Research (CIMR) and the MRC Mitochondrial Biology Unit (MBU). These form part of the University of Cambridge Clinical School based on the Cambridge Biomedical Campus.

An opportunity has arisen to join a team of four Receptionists who provide that all-important first point of contact for incoming telephone calls and visitors to the Building. The role will also be involved in sorting mail, organising room bookings, maintaining the security card database and other general reception duties.

Hours worked are on a shift pattern of two days one week and three days the next averaging 16 hours per week (08.00-15.00 hours or 09.15-17.00 hours, depending on shift). You will also be expected to cover for holiday and sickness absence as and when required, reimbursed by overtime payments.

You will possess good interpersonal skills, have a welcoming, positive and polite manner and a smart appearance (a uniform will be provided). Basic IT skills would be an advantage and in-house training will be provided.

Further information about the role including role overview, duties, responsibilities and person specification are available below.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online application form.

The position is available from May 2022.

The University of Cambridge has implemented a University of Cambridge Living Wage, which sets a minimum rate of pay of £10/hour for all employees (equal to a full-time annual salary of £19,071 based on a 36.5 hour week). The University will pay this as a supplement for the difference between the base hourly rate and the University of Cambridge Living Wage.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For specific enquiries about the role, contact: Charlotte Yelton, HR Supervisor, email caay2@cam.ac.uk

Please quote reference SA30450 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.