Assistant Research Professor in the structural basis of stress signalling systems
Recent developments in prediction of protein structure and ligand binding have created exciting opportunities for discovery of tool compounds to explore hitherto inaccessible aspects of life science. To exploit these developments, we seek a highly independent scientist with capabilities that span the full pipeline of tools required to discover such compounds, including experimental structural determination using multiple approaches and the application and ab initio development of complex computational tools.
The role-holder will serve as the primary laboratory authority in structural biology, biophysics and the interface with chemical biology, as applied to stress signalling systems in mammals. Therefore, we seek a highly experienced structural biologist/biochemist/biophysicist, evidenced by leadership in relevant publications and wide-ranging technical expertise, to lead and innovate research integrating experimental structural determination and biochemistry with computational modelling and AI-driven approaches. They will be responsible for the discovery of novel tool compounds that drive understanding of the molecular mechanisms of stress signaling systems.
The successful candidate will join a small multidisciplinary team within CIMR, contributing, in a leadership role to high-impact projects and mentoring junior researchers.
The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.
Appointment at Assistant Research Professor (or equivalent) level, is subject to meeting the relevant criteria and Faculty Board approval is required before any job offer can be made.
Funding is available until September 2027 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Closing date: 26th February 2026
Interviews will be held at the beginning of March
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
For information about how your personal data is used as an applicant, please see the section on Applicant Data (https://www.hr.admin.cam.ac.uk/hr-staff/hr-data/applicant-data) on our HR web pages.
Please quote reference SG48757 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Associate (Fixed Term)
We are seeking to recruit an experienced and well organised postdoctoral researcher to carry out research to understand transcriptional and functional changes as CTLs are activated by different stimuli. The research group is part of the Cambridge Institute for Medical Research on the Cambridge Biomedical Campus. The lab works on the molecular mechanisms that control killing by cytotoxic T lymphocytes, important cells of the immune system that kill virally infected and cancer cells. Our research combines cell biology and immunology, using genetic approaches including CRISPR and single cell RNA sequencing of primary lymphocytes, together with high-resolution imaging.
The holder of the post will be experienced in single cell RNA sequencing of primary lymphocytes and the impact of TCR signal strength on signalling pathways in naïve and activated CTLs. Work will include handling primary cells, extracting RNA for experiments as well as coding required for analysis. The candidate must have published work in this area of biology and will need to write up work previously carried out in the laboratory. Additionally, the candidate must be able to work with clinical colleagues in any collaborative projects.
The applicant must be a postgraduate in transcriptomic analysis and signal strength of CTLs, able to take part in clinical collaborations in this area.
The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.
This post is available immediately and funding is available until February 2027 in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.
We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Closing date: 18th February 2026
Interview date: to be confirmed
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
For information about how your personal data is used as an applicant, please see the section on Applicant Data (https://www.hr.admin.cam.ac.uk/hr-staff/hr-data/applicant-data) on our HR web pages.
Please quote reference SC48741 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
Research Assistant or Research Associate (Fixed Term)
We are seeking an enthusiastic, motivated individual for a position in the group of Professor Mike Weekes, Department of Medicine in the Cambridge Institute for Medical Research at the Cambridge Biomedical Campus. You will join an exciting research programme investigating novel aspects of viral sensing and the function of key uncharacterised viral evasins. This post will involve the use of cutting-edge proteomics and biochemistry.
This position is available for an immediate appointment. Candidates must either have a PhD in a relevant biological subject, or have submitted or about to submit their PhD thesis. Candidates must also have demonstrable expertise in virology, cell biology and/or molecular biology. Additional training in proteomics will be provided. Relevant post-doctoral experience is desirable. High quality peer-reviewed publications and a keen interest in viral/cellular regulation are essential.
If you have an excellent background in biological sciences, are prepared to face intellectual challenges and wish to develop your scientific skills, we would like to hear from you. Applicants should have outstanding organisation and communication skills, and work well as part of a team.
The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.
Funding for this position is for 3 years in the first instance with a start date as soon as possible.
For recent related publications, see below:
Nightingale et al. (2018) Cell Host & Microbe doi: 10.1016/j.chom.2018.07.011 Albarnaz et al. (2023) Nature Communications. doi: 10.1038/s41467-023-43299-8 Ravenhill et al. (2025) Cell Reports. doi: 10.1016/j.celrep.2025.115263
Informal enquiries to Professor Mike Weekes: mpw1001@cam.ac.uk
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SC48447 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.