CIMR vacancies on www.jobs.cam.ac.uk

Applications are invited for a Research Associate to study the molecular details of IRE1 activation and complete a research project previously initiated in the laboratory.

You will join a team led by Professor David Ron studying protein folding homeostasis in the Endoplasmic Reticulum. You will be primarily responsible for application of molecular and cellular biology tools to explore the mechanisms of IRE1 activation. You are expected to lead this project drawing on the advances previously made and described in PMID: 31873072, 38177498, 38177501.

Duties include but are not limited to: Design and creation of genetically modified cells using CRISPR/Cas9 gene editing to test specific hypothesis on the basis of IRE1 activation. Design and execution of complex multi-channel FACS experiments exploiting the cells described above. Design, expression and purification of bacterial-expressed proteins used in the study of IRE1 regulation in vitro. Implementing biophysical techniques used to study IRE1 regulation in vitro: analytical size exclusion chromatography by HPLC, Mass photometry, Analytical Ultracentrifugation, Fluorescence resonance energy transfer (FRET), Bioluminescence resonance energy transfer (BRET), Fluorescent polarisation and biolayer interferometry (BLI). Applicants should have PhD or equivalent degree in Biomedical Science, Biochemistry, Genetics or a related discipline.

Requirements are:

A proven track record of success in applying multidimensional FACS analysis, molecular biology and protein chemistry techniques to the study of protein folding homeostasis in the Endoplasmic Reticulum.

A proven track record of success in design, creation and genetic and phenotypic validation of multiple modified cell lines using CRISPR/Cas9 in the study of protein folding homeostasis in the Endoplasmic Reticulum.

A proven track record of success in applying biophysical techniques of Analytical SEC, Mass photometry, AUC, FRET, BRET and FP to the study of the unfolded protein response.

Good communication, team-work, organisational and record keeping skills are essential.

Preference will be given to applicants with familiarity with the laboratory's knock-in system for studying IRE1 chimeras and a track-record of publication in the area of IRE1 activation.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Please contact Professor David Ron at dr360@cam.ac.uk for further information

Fixed-term: The funds for this post are available until 30 June 2025 in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager

Please quote reference SG41526 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work on a project that explores the function of a multi-gene family that is expanded in the genomes of Plasmodium Vivax and other related neglected human malaria parasites. The project builds on a recent publication that established that these tryptophan-rich antigens (TRAgs) have lipid binding activity (PMID: 37709739). It will expand on these initial findings using CRISPR/Cas9 genetic modification to knockout and tag multiple TRAg genes in Plasmodium Knowlesi and explore their function using a range of cell biological and biochemical assays.

To hit the ground running the successful candidate will need hands-on and demonstrable experience in culturing and transfecting Plasmodium parasites, preferably specifically Plasmodium Knowlesi. You will also have extensive experience in using molecular biology techniques (e.g. Gibson Assembly) to generate and validate complex genetic manipulation vectors, as well as in relevant cell biology techniques such as advanced microscopy and flow cytometry. There is also the potential to be involved in more biochemical focussed work, including recombinant protein expression and crystallography, if that is of interest. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement. You will work as part of a vibrant interdisciplinary team and in close collaboration with colleagues in both the Rayner and Deane Laboratories in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed, and you will present your work regularly at both internal and external academic events. The role has the potential to be a key stepping stone in a research career and multiple career development and support opportunities are available.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Applicants must have (or be close to obtaining) a PhD.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £31,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SG41220 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Cambridge Institute for Medical Research (CIMR) is seeking to appoint an experienced IT Technician to join a small team supporting a community of researchers and staff within a modern research facility.

The successful applicant will assist with the management and development of a broad IT infrastructure, and will share responsibility for all aspects of IT provision, from server and network infrastructure through to desktop and audio-visual support.

The Institute offers a busy but friendly working environment, and would suit self-motivated candidates with communication skills of a high standard.

Applicants should be educated to degree level, and will already have accomplished skills in at least 3 of the following areas:

• Cisco switching and routing
• Linux system administration
• Windows desktop support and current PC hardware
• Apple Mac support
• Windows Server and Active Directory
• MySQL, Oracle, or PHP/Python web development

The successful candidate will be given training as required to ensure cross-cover within the IT team.

The role is full time on-site, but we are open to applications from individuals who wish to be considered for part-time working or other flexible working arrangements. The nature of the role and the team requires a minimum of 80%, for example working 4 days per week, or 5 days per week with shorter hours.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you outline how you match the criteria for the post and why you are applying for this role on the online Application form.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 21st April 2024

The interview date for the role is: End of April/Beginning of May

Please quote reference SA41049 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Understanding Mechanisms in Familial Interstitial Lung Disease Using Organoid Models

Dr Dickens and the Marciniak Group are seeking a postdoctoral researcher to drive innovation in a programme of research investigating triggers of alveolar epithelial dysfunction in familial forms of interstitial lung disease. You will work with novel alveolar organoids, creating patient-specific models which you will interrogate using innovative culture techniques, genetic manipulation and multi-omics analysis including proteomics and transcriptomics with a view to identifying novel therapeutic targets.

You should have a track record in wet-lab cell biology and possess a PhD in a relevant discipline. Prior experience of working with organoids would be an advantage, but training will be provided.

The successful applicant will join Dr Dickens, a clinician scientist, and a diverse team of basic and translational scientists and clinicians within the Marciniak Group. We are committed to promoting an exciting, rewarding and healthy working environment and strive to support the career goals of our team members.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

Recent relevant papers Lim K, Rutherford EN, Sun D, Van den Boomen DJH, Edgar JR, Bang J, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. BioRxiv (https://doi.org/10.1101/2023.08.30.555522)

Dickens JA, Rutherford EN, Abreu S, Chambers JE, Ellis MO, van Schadewijk A, Hiemstra P, Marciniak SJ. Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant. Eur Respir J 2022;59:2100267

Please contact Dr Jenny Dickens at jac72@cam.ac.uk for further information.

Fixed-term: The post will run for 3 years in the first instance.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 17th April 2024

The interview date for the role is: Beginning of May 2024

Please quote reference SC40999 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The laboratory of Dr. Jeanne Salje at the Cambridge Institute for Medical Research (CIMR), University of Cambridge, is seeking a highly motivated and talented Postdoctoral Fellow to join their team. The successful candidate will work on developing and generating arthropod models to study host-pathogen interactions of Rickettsiales bacteria, as well as optimising experimental protocols for the maintenance and manipulation of arthropod vectors. The post holder will be expected to perform molecular biology techniques including cloning, DNA manipulation, PCR, and to analyse experimental data, interpret results, and contribute to publications and presentations. You should also have the ability to characterize host-pathogen interactions using microscopy, molecular assays, and other relevant techniques.

All applicants should hold a PhD in microbiology, genetics, molecular biology or a related discipline. Collaborating with other members of the research team to achieve goals, and contributing to the training and supervision of technicians, graduate and undergraduate students are key responsibilities for this role. A proven track record of scientific productivity is essential and you will have strong organisational and communication skills with the ability to effectively prioritise lab duties, both independently and as part of a team.

This position is graded on the University's Grade 7 scale, for which the salary range is £36,024-£44,263 per annum. The actual starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.

For informal enquiries please contact Dr Jeanne Salje (jss53@cam.ac.uk).

Fixed-term: This is a full-time, fixed-term position for two years, with the possibility of extension contingent on funding availability and performance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 28th March 2024

The interview date for the role is: Beginning of April

Please quote reference SH40920 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

We are seeking an enthusiastic and skilled Research Associate to join the Nixon-Abell Laboratory at the Cambridge Institute for Medical Research. Our work sits at the interface between cell biology and molecular neuroscience. We employ integrated experimental approaches, combining cutting-edge microscopy, biochemistry, omics and iPSC-derived cell models to understand organelle interactions and dynamics in neurons.

This Wellcome Trust funded project aims to draw fundamental links between organellar communication pathways and neuronal activity. Specifically, the post-holder will focus on understanding how sites of direct physical interaction between organelles (membrane contact sites) coordinate the intracellular distribution of ions/lipids/metabolites to facilitate neuronal transmission. The candidate will form part of a vibrant and interdisciplinary team focussed on producing rigorous, innovative and impactful research. This role will also offer various career development opportunities to support the candidate's professional progression.

All applicants must hold (or imminently be receiving) a PhD in a relevant field and have research experience in mechanistic cell biology and/or molecular neuroscience. Prior post-doctoral research experience is highly desirable. A background in membrane contact sites and/or neuronal cell biology would be advantageous and technical experience in one of more of the following would be highly beneficial: stem cell culture, neuronal differentiation, lipidomics/metabolomics/proteomics, CRISPR genome editing, advanced microscopy and bioinformatics. Previous experience working with lipids and/or Ca2+ biology is preferable, although not required.

The successful applicant will be expected to work independently and collaboratively as part of a diverse team.

This full-time fixed-term post is funded by the Wellcome Trust for 3 years in the first instance. This position is graded on the University's salary range for Grade 5 which is £29,605 - £33,966 or Grade 7 (upon award of PhD) £36,024 - £44,263 per annum. The starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

For informal enquiries please contact Dr Jonathon Nixon-Abell (jjn36@cam.ac.uk).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 2 April 2024

Interview date: Mid April 20024

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SD40768 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for an enthusiastic and motivated Research Assistant to join the Nixon-Abell laboratory at the Cambridge Institute for Medical Research. Our work sits at the interface between cell biology and molecular neuroscience. We employ integrated experimental approaches to understand organelle interactions and dynamics in neurons, and how they are corrupted in neurodegenerative diseases.

The successful candidate will work closely with several post-doctoral researchers to conduct and coordinate experiments while performing key duties to support the laboratory (iPSC tissue culture, molecular biology and laboratory management). As this position is a longer-term placement, the successful applicant will also have the exciting opportunity to work on their own dedicated research project, with the goal of producing rigorous and impactful research and publications. The candidate will form part of a vibrant and interdisciplinary team and receive expert training and guidance to develop skills in stem cell culture, neuronal differentiation, molecular biology, CRISPR engineering, and advanced microscopy.

All applicants must hold at minimum a BSc in biochemistry, cell biology, neuroscience or a related discipline and have prior experience working in a lab environment. Candidates with an MSc are preferable, although not required. Excellent record keeping, organisational skills, and communication ability are essential.

This full-time fixed-term post is funded by the Wellcome Trust for 2 years in the first instance, but with the potential for extension. This position is graded on the University's Grade 5 scale, for which the salary range is £29,605 - £33,966 per annum. The starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

For informal enquiries please contact Dr Jonathon Nixon-Abell (jjn36@cam.ac.uk).

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Closing date: 2 April 2024

Interview date: Mid April 2024

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SD40767 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Applications are invited for a talented Postdoctoral Research Associate in the Group of Dr Melissa Gammons. This is an exciting opportunity for an experienced molecular/cellular biologist to break new scientific ground investigating the molecular mechanisms of Wnt signal transduction pathways and how these are disrupted in disease. The successful candidate will be expected to design, carry out and appropriately analyse experiments encompassing cell-based assays, proteomics screens, super-resolution microscopy and protein biochemistry using state-of-the-art tools and resources. The post-holder will be expected to work independently yet collaboratively to achieve the goals of the projects. Good record keeping, high scientific integrity and a friendly, collegial attitude is essential.

Applicants should hold a PhD in biochemistry, biophysics, molecular biology or a related discipline. You should have the ability to design and implement experiments and have substantial experience in molecular biology techniques. A proven track record of producing high quality data is essential and you will have strong organisational and communication skills with the ability to effectively prioritise lab duties, both independently and as part of a team.

This full-time fixed-term post is funded by the Wellcome Trust for 3 years in the first instance and is based at the Cambridge Institute for Medical Research (CIMR), Cambridge Biomedical Campus, Cambridge.

This position is graded on the University's Grade 7 scale, for which the salary range is £36,024-£44,263 per annum. The actual starting salary offered will be based on qualification and relevant skills acquired and will be determined by the funding available.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

For informal enquiries please contact Dr Melissa Gammons (mg2128@cam.ac.uk).

Closing date: 02 April 2024

Interview date: mid-April 2024, exact date to be confirmed

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SE40758 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The Rayner Lab at the Cambridge Institute for Medical Research is recruiting a Research Associate to work on a project that combines Plasmodium knowlesi parasite culture and transfection with molecular biology in a chemogenomics approach to identify new antimalarial drug targets. As the project is already underway and has short delivery timelines we are looking for someone with extensive experience in the relevant techniques.

To hit the ground running the successful candidate will need extensive experience specifically in culturing and transfecting Plasmodium knowlesi parasites, in molecular biology techniques relevant to the generation and purification of hundreds of transfection plasmids in parallel and in analysing and interpreting Illumina sequencing data. You will also have existing working knowledge of UK biosafety regulations and restrictions in order to allow you to work in the CL3 malaria parasite culture lab. Your primary focus will be on carrying out outstanding academic research leading to impactful papers, providing substantial scope for innovation, creativity and scientific judgement.

You will work as part of a vibrant interdisciplinary team and in close collaboration with partners and colleagues in the Cambridge Institute for Medical Research. You are expected to contribute to the collaborative team environment, supporting and training others where needed and you will present your work regularly at both internal and external academic events. The role has the potential to be a key stepping stone in a research career and multiple career development and support opportunities are available.

This is a short-term post with funding available until 30th September 2024.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are welcomed and should be directed to: Sara Asbury, email director-pa@cimr.cam.ac.uk

Closing date: 14 February 2024

Interview date: to be confirmed

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SG40398 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.