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Alpha-synuclein mutations mislocalise cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 anti-trypsin deficiency
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
Nuclear proteasomes buffer cytoplasmic proteins during autophagy 1 compromise
Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
VAMP2 regulates phase separation of α-synuclein
Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response
Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle
The ALBORADA Drug Discovery Institute
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Dr Pawel Obrocki
01223 336905
po286@cam.ac.uk
Clinical Research Training Fellow, Rubinsztein Lab
Professor David Owen
01223 762 643
djo30@cam.ac.uk
Professor of Structural and Molecular Biology
